Morphogen Gradient from a Noisy Source
组织与器官
2007-05-23 v1 其他凝聚态物理
分子网络
其他定量生物学
摘要
We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed.
引用
@article{arxiv.q-bio/0502036,
title = {Morphogen Gradient from a Noisy Source},
author = {Jeremy L. England and John Cardy},
journal= {arXiv preprint arXiv:q-bio/0502036},
year = {2007}
}
备注
Four pages, three figures