Manipulating single enzymes by an external harmonic force
生物大分子
2007-05-23 v2 统计力学
摘要
We study a Michaelis-Menten reaction for a single two-state enzyme molecule, whose transition rates between the two conformations are modulated by an harmonically oscillating external force. In particular, we obtain a range of optimal driving frequencies for changing the conformation of the enzyme thereby controlling the enzymatic activity (i.e. product formation). This analysis demonstrates that it is, in principle, possible to obtain information about particular rates within the kinetic scheme.
关键词
引用
@article{arxiv.q-bio/0611011,
title = {Manipulating single enzymes by an external harmonic force},
author = {Michael A. Lomholt and Michael Urbakh and Ralf Metzler and Joseph Klafter},
journal= {arXiv preprint arXiv:q-bio/0611011},
year = {2007}
}
备注
4 pages, 6 figures, minor changes, to appear in Phys. Rev. Lett