Gene networks from DNA microarray data: centrality and lethality
统计力学
2007-05-23 v2 生物物理
分子网络
摘要
We construct a gene network based on expression data from DNA microarray experiments, by establishing a link between two genes whenever the Pearson's correlation coefficient between their expression profiles is higher than a certain cutoff. The resulting connectivity distribution is compatible with a power-law decay with exponent ~1, corrected by an exponential cutoff at large connectivity. The biological relevance of such network is demonstrated by showing that there is a strong statistical correlation between high connectivity number and lethality: in close analogy to what happens for protein interaction networks, essential genes are strongly overerpresented among the hubs of the network, that is the genes connected to many other genes.
引用
@article{arxiv.cond-mat/0207345,
title = {Gene networks from DNA microarray data: centrality and lethality},
author = {P. Provero},
journal= {arXiv preprint arXiv:cond-mat/0207345},
year = {2007}
}