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Microscopy is one of the most essential imaging techniques in life sciences. High-quality images are required in order to solve (potentially life-saving) biomedical research problems. Many microscopy techniques do not achieve sufficient…

Computer Vision and Pattern Recognition · Computer Science 2018-10-24 Joris Roels , Jan Aelterman , Jonas De Vylder , Hiep Luong , Yvan Saeys , Wilfried Philips

This comprehensive review discusses the development of scanning electron microscopy and the application of this technology in different fields such as biology, nanobiotechnology and biomedical science. Besides being a tool for high…

Quantitative Methods · Quantitative Biology 2023-11-02 Aniruddha Acharya

The photon counting imaging paradigm in the visible and the infrared comes from the very small energy carried by a single photon at these wavelengths. Usually to detect photons the photoelectric effect is used. It converts a photon to a…

Instrumentation and Methods for Astrophysics · Physics 2022-07-28 Jean-Luc Gach , Isaure De Kernier , Philippe Feautrier

Nowadays, modern electron microscopes deliver images at atomic scale. The precise atomic structure encodes information about material properties. Thus, an important ingredient in the image analysis is to locate the centers of the atoms…

Computer Vision and Pattern Recognition · Computer Science 2017-09-13 Benjamin Berkels , Benedikt Wirth

The Electron Multiplying Charge Coupled Devices (EMCCD), owing to their high quantum efficiency and spatial resolution, are widely used to study typical quantum optical phenomena and related applications. Researchers have already developed…

Quantum Physics · Physics 2024-11-12 Rounak Chatterjee , Vikas Bhat , Kiran Bajar , Sushil Mujumdar

Error-control-coding (ECC) techniques are widely used in modern digital communication systems to minimize the effect of noisy channels on the quality of received signals. Motivated by the fact that both communication and imaging can be…

Image and Video Processing · Electrical Eng. & Systems 2018-09-20 Xiaopeng Wang , Zunwang Bo , Zihuai Lin , Wenlin Gong , Branka Vucetic , Shensheng Han

In this paper, we show how we can combine Electromagnetics (EM) with signal processing algorithms to enhance the image resolution over that can be realized by using Electromagnetics techniques alone. We discuss several signal processing…

Optics · Physics 2013-05-14 Xiang Gu , Chiara Pelletti , Raj Mittra , Yunhua Zhang

Quantitative electron magnetic circular dichroism (EMCD) in transmission electron microscopy (TEM) enables the measurement of magnetic moments with elemental and atomic site sensitivity, but its practical application is fundamentally…

Materials Science · Physics 2025-10-29 Hitoshi Makino , Bernd Rellinghaus , Sebastian Schneider , Axel Lubk , Darius Pohl

Deep-UV ~ 250 nm (4.96 eV) tilted in-situ co-illumination of the sample under imaging by scanning electron microscope (SEM) is developed at a robust and practical instrument level. Precise mechanical control of the lateral position and tilt…

Here a new microscopic method is proposed to image and characterize very thin samples like few-layer materials, organic molecules, and nanostructures with nanometer or sub-nanometer resolution using electron beams of energies lower than 20…

Instrumentation and Detectors · Physics 2016-01-06 Ing-Shouh Hwang

Automatic image segmentation is a critical component of medical image analysis, and hence quantifying segmentation performance is crucial. Challenges in medical image segmentation are mainly due to spatial variations of regions to be…

Image and Video Processing · Electrical Eng. & Systems 2021-09-09 Ammu R , Neelam Sinha

The noise in the depth profiles of secondary ion mass spectrometry (SIMS) is studied using different samples under various experimental conditions. Despite the noise contributions from various parts of the dynamic SIMS process, its overall…

Materials Science · Physics 2009-10-28 D. P. Chu , M. G. Dowsett , G. A. Cooke

Purpose: Electron density is the most important tissue property influencing photon and ion dose distributions in radiotherapy patients. Dual-energy computed tomography (DECT) enables the determination of electron density by combining the…

Medical Physics · Physics 2017-06-29 Christian Möhler , Patrick Wohlfahrt , Christian Richter , Steffen Greilich

In scanning electron microscopy, the achievable image quality is often limited by a maximum feasible acquisition time per dataset. Particularly with regard to three-dimensional or large field-of-view imaging, a compromise must be found…

Computer Vision and Pattern Recognition · Computer Science 2018-01-15 Patrick Trampert , Faysal Bourghorbel , Pavel Potocek , Maurice Peemen , Christian Schlinkmann , Tim Dahmen , Philipp Slusallek

In this study, we present a computational framework tailored for the precise detection and comprehensive analysis of nanoparticles within scanning electron microscopy (SEM) images. The primary objective of this framework revolves around the…

Image and Video Processing · Electrical Eng. & Systems 2023-08-21 Aidan S. Wright , Nathaniel P. Youmans , Enrique F. Valderrama Araya

Studying the electrical signals generated by living cells is key to understanding numerous biological phenomena. Electrochromic optical recording (ECORE) uses the electrochromism exhibited by certain materials to noninvasively measure these…

Different tasks in the computational pipeline of single-particle cryo-electron microscopy (cryo-EM) require enhancing the quality of the highly noisy raw images. To this end, we develop an efficient algorithm for signal enhancement of…

Image and Video Processing · Electrical Eng. & Systems 2022-12-06 Guy Sharon , Yoel Shkolnisky , Tamir Bendory

The achievable beam current and beam quality of a particle accelerator can be limited by the build-up of an electron cloud (EC) in the vacuum chamber. Secondary electron emission from the walls of the vacuum chamber can contribute to the…

Transmission Electron Microscopy (TEM) is a powerful tool for imaging material structure and characterizing material chemistry. Recent advances in data collection technology for TEM have enabled high-volume and high-resolution data…

Computer Vision and Pattern Recognition · Computer Science 2021-08-24 Josh Kacher , Yao Xie , Sven P. Voigt , Shixiang Zhu , Henry Yuchi , Jordan Key , Surya R. Kalidindi