Microscopy of Bioelectric Potentials using Electrochromism
Abstract
Studying the electrical signals generated by living cells is key to understanding numerous biological phenomena. Electrochromic optical recording (ECORE) uses the electrochromism exhibited by certain materials to noninvasively measure these signals in real time. In this work, we report on the development of ECORE based on a high-NA microscope objective. We demonstrate the recording of extracellular action potentials from cardiomyocytes with single-cell resolution and a high sensitivity of 3 {\mu}V, which compares favorably to the previous record for any ECORE setup. Combining ECORE with microscopy simplifies the optical setup, allows for the simultaneous imaging of specimens, and makes ECORE accessible to a broader community of researchers, allowing for a better understanding of the biological processes that are integral to life.
Cite
@article{arxiv.2602.00363,
title = {Microscopy of Bioelectric Potentials using Electrochromism},
author = {Burhan Ahmed and Erica Liu and Lothar Maisenbacher and Pengwei Sun and Dana Griffith and Kenneth Nakasone and Yuecheng Zhou and Bianxiao Cui and Holger Müller},
journal= {arXiv preprint arXiv:2602.00363},
year = {2026}
}