Related papers: Status and development of the TOP-IMPLART Project
An efficient approach that considers a high-intensity twisted laser of moderate energy (few J) is proposed to generate collimated proton bunches with multi-10-MeV energies from a double-layer hydrogen target. Three-dimensional…
Targeted Radionuclide Therapy (TRT) is a well-established technique for cancer treatment. In this approach, radionuclides are bound to specific drugs that selectively transport them to the tumor site. Within the ISOLPHARM project, a…
Proton and carbon ion therapy is an emerging technique used for the treatment of solid cancers. The monitoring of the dose delivered during such treatments and the on-line knowledge of the Bragg peak position is still a matter of research.…
Ultra intense lasers are a promising source of energetic ions for various applications. An interesting approach described in Ferri et al. 2019 argues from Particle-in-Cell simulations that using two laser pulses of half energy (half…
We present the experimental results on ion acceleration by petawatt femtosecond laser solid interaction and explore strategies to enhance ion energy. The irradiation of micrometer thick (0.2 - 6.0 micron) Al foils with a virtually…
Laser-driven ion acceleration is an attractive technique for compact high-energy ion sources. Currently, among various physical and technical issues to be solved, the boost of ion energy and the reduction of energy spread represent the key…
In the context of particle therapy monitoring, we are developing a gamma-ray detector to determine the ion range in vivo from the measurement of particle time-of-flight. For this application, a beam monitor capable to tag in time the…
A target composition scheme to optimize the combined proton acceleration regime is presented and verified by two-dimensional particle-in-cell (2D PIC) simulations by using an ultra-intense circularly-polarized (CP) laser pulse irradiating…
Objective. Prompt-gamma imaging encompasses several approaches for online monitoring of beam range or deposited dose distribution in proton therapy. We test one of the imaging techniques - a coded mask approach - both experimentally and via…
Purpose: The terahertz (THz) medical imaging is a promising noninvasive technique for monitoring the skin's conditions, early detection of the human skin cancer, and recovery from burns and wounds. It can be applied for visualization of…
Immunotherapies have revolutionized cancer treatment. Unlike chemotherapies, immune agents often take longer time to show benefit, and the complex and unique mechanism of action of these agents renders the use of multiple endpoints more…
The relativistically induced transparency acceleration (RITA) scheme of proton and ion acceleration using laser-plasma interactions is introduced, modeled, and compared to the existing schemes. Protons are accelerated with femtosecond…
Efficient laser ion acceleration requires high laser intensities, which can only be obtained by tightly focusing laser radiation. In the radiation pressure acceleration regime, where the tightly focused laser driver leads to the appearance…
The purpose of this study is to determine whether organ sparing and target coverage can be simultaneously maintained for pencil beam scanning (PBS) proton therapy treatment of thoracic tumors in the presence of motion, stopping power…
The interaction of ultraintense laser pulses with solids is largely affected by the plasma gradient at the vacuum-solid interface, which modifies the absorption and ultimately, controls the energy distribution function of heated electrons.…
We present a new acceleration scheme capable of accelerating electrons and ions in an underdense plasma. Transversely Pumped Acceleration (TPA) uses multiple arrays of counter-propagating laser beamlets that focus onto a central…
The production of polarized proton beams with multi-GeV energies in ultra-intense laser interaction with targets is studied with three-dimensional Particle-In-Cell simulations. A near-critical density plasma target with pre-polarized proton…
We study numerically the mechanisms of proton acceleration in gas-foil targets driven by an ultraintense femtosecond laser pulse. The target consists of a near-critical-density hydrogen gas layer of a few tens of microns attached to a solid…
High-quality proton beams generated by laser-plasma interactions are of significant interest for applications ranging from tumor therapy to fast ignition in inertial confinement fusion. However, simultaneously achieving high energy coupling…
We propose a hybrid laser-driven ion acceleration scheme using a combination target of a solid foil and a density-tailored background plasma. In the first stage, a sub-relativistic proton beam can be generated by the radiation pressure…