Related papers: Status and development of the TOP-IMPLART Project
To expedite the commissioning process of the proton therapy system at Samsung Medical Center (SMC), we have developed a Monte Carlo simulation model of the proton therapy nozzles using TOPAS. At SMC proton therapy center, we have two gantry…
During proton therapy, the beam flux decreases due to inelastic interactions with nuclei. At the highest energies used in proton therapy around 25\% protons initiate nuclear reactions. This report presents the cross section measurements of…
The use of the existing proton storage rings combined with electron linear accelerator as a ring-linac type electron-proton or photon-proton collider is investigated. The total CM-energy of Proton-ring and Electron-linac Collider (PRELC) is…
A new scheme of proton acceleration from a laser-driven near-critical-density plasma is proposed. Plasma with a tailored density profile allows a two-stage acceleration of protons. The protons are pre-accelerated in the laser-driven…
We report on an hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA…
The radiation pressure acceleration (RPA) of charged particles has been considered a challenging task in laser particle acceleration. Laser-driven proton/ion acceleration has attracted considerable interests due to its underlying physics…
Compact laser-plasma acceleration of fast ions has made great strides since its discovery over two decades ago, resulting in the current generation of high-energy ($\geq 100\,\rm MeV$) ultracold beams over ultrashort ($\leq 1\,\rm ps$)…
A new electron injection scheme is proposed in sub-relativistic plasma wakefield accelerators. A transverse laser ionizes a dopant gas and ponderomotively accelerates the released electrons in the direction of wake propagation. This process…
It is shown that the energy of protons accelerated in laser-matter interaction experiments may be significantly increased through the process of splitting the incoming laser pulse into multiple interaction stages of equal intensity. From a…
Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…
Proton therapy has been rapidly advancing due to its excellent conformal index, but its relatively low relative biological effect (RBE) has somewhat limited its therapeutic efficacy for certain tumors. To address this, we previously…
Dosimetry in BNCT poses significant challenges due to the indirect effect of neutrons interacting with elements within the body and uncertainties associated with the uptake of boron compounds used in clinical practice. Current treatment…
The interaction of a high-intensity ultrashort laser pulse with a few microns-thick hydrocarbon target is known to accelerate protons/ions to multi-MeV, on the rear side of the target, via the mechanism of target normal sheath acceleration.…
The LIGHT (Linac for Image-Guided Hadron Therapy) project was initiated to develop a modular proton accelerator delivering beam with energies up to 230 MeV for cancer therapy. The machine consists of three different kinds of accelerating…
In this study, we conduct a study on magnetic hyperthermia treatment when a vessel is located near the tumor. The holistic framework is established to solve the process of tumor treatment. The interstitial tissue fluid, MNP distribution,…
We propose a scheme to overcome the great challenge of polarization loss in spin-polarized ion acceleration. When a petawatt laser pulse penetrates through a compound plasma target consisting of a double layer slab and prepolarized hydrogen…
Photothermal therapy (PTT) has shown significant potential in cancer treatment. However, developing nanomaterial-based photothermal agents with good biocompatibility and high photothermal conversion efficiency (PTCE) remains a key…
We study proton acceleration from a foil target with a transversely varying density using multi-dimensional Particle-in-Cell (PIC) simulations. In order to reduce electron heating and deformation of the target, circularly polarized Gaussian…
The influence of laser frequency on laser-driven ion acceleration is investigated by means of two-dimensional particle-in-cell simulations. When ultrashort intense laser pulse at higher harmonic frequency irradiates a thin solid foil, the…
Short single-walled carbon nanotubes (SWNTs) functionalized by PEGylated phospholipids are biologically non-toxic and long-circulating nanomaterials with intrinsic near infrared photoluminescence (NIR PL), characteristic Raman spectra, and…