Monte Carlo simulation of the ISOLPHARM gamma camera for Ag-111 imaging
Abstract
Targeted Radionuclide Therapy (TRT) is a well-established technique for cancer treatment. In this approach, radionuclides are bound to specific drugs that selectively transport them to the tumor site. Within the ISOLPHARM project, a radiopharmaceutical for TRT based on the innovative radionuclide Ag-111 is currently under development. Ag-111 has a half-life of 7.45 days and decays by emitting both electrons and gamma-rays. The emission of gamma-rays, predominantly at an energy of 342 keV, enables the visualization of Ag-111 using a gamma camera. In this work, we describe a Monte Carlo simulation developed to optimize the design parameters of such an imaging device. The simulation is based on the Geant4 toolkit, which accurately models the interactions between particles and matter. The estimated spatial resolution and sensitivity of the system are approximately 4 mm and 19 cps/MBq, respectively. The simulated device is able to resolve lesions with a lesion-to-background activity ratio of 4:1 under in-vivo-like conditions. These results indicate that the proposed gamma camera can provide cost-effective imaging capabilities for preclinical radiopharmaceutical studies.
Cite
@article{arxiv.2502.20112,
title = {Monte Carlo simulation of the ISOLPHARM gamma camera for Ag-111 imaging},
author = {D. Serafini and A. Leso and A. Arzenton and S. Spadano and E. Borciani and D. Chen and C. Sbarra and M. Negrini and A. Margotti and N. Lanconelli and G. Baldazzi and E. Mariotti and S. Corradetti and A. Andrighetto},
journal= {arXiv preprint arXiv:2502.20112},
year = {2026}
}
Comments
10 pages, 5 figures, to be published in JINST for the conference ICFDT7. New version was produced according to the reviewers comments