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After birth setting up an effective immune system is a major challenge for all living organisms. In this paper we show that this process can be explored by using the age-specific infant death rate as a kind of sensor. This is made possible…

Medical Physics · Physics 2016-10-10 Peter Richmond , Bertrand M. Roehner

It is evident that increasing the intensive-care-unit (ICU) capacity and giving priority to admitting and treating younger patients will reduce the number of COVID-19 deaths, but a quantitative assessment of these measures has remained…

Physics and Society · Physics 2020-12-29 Ying-Qi Zeng , Lang Zeng , Ming Tang , Ying Liu , Zong-Hua Liu , Ying-Cheng Lai

We use the illness-death model (IDM) for chronic conditions to derive a new analytical relation between the transition rates between the states of the IDM. The transition rates are the incidence rate (i) and the mortality rates of people…

Methodology · Statistics 2024-02-23 Maryam Saem , Ralph Brinks

Mixed Models for Repeated Measures (MMRMs) are ubiquitous when analyzing outcomes of clinical trials. However, the linearity of the fixed-effect structure in these models largely restrict their use to estimating treatment effects that are…

Methodology · Statistics 2023-01-23 Lars Lau Raket

Identifying optimal medical treatments to improve survival has long been a critical goal of pharmacoepidemiology. Traditionally, we use an average treatment effect measure to compare outcomes between treatment plans. However, new methods…

Dementia currently affects about 50 million people worldwide, and this number is rising. Since there is still no cure, the primary focus remains on preventing modifiable risk factors such as cardiovascular factors. It is now recognized that…

Methodology · Statistics 2024-08-14 Léonie Courcoul , Catherine Helmer , Antoine Barbieri , Hélène Jacqmin-Gadda

Regression discontinuity design (RDD) is a quasi-experimental approach to study the causal effects of an intervention/treatment on later health outcomes. It exploits a continuously measured assignment variable with a clearly defined cut-off…

Applications · Statistics 2024-06-28 Maja Popovic , Daniela Zugna , Lorenzo Richiardi

In this paper, we provide causal evidence on abortions and risky health behaviors as determinants of mental health development among young women. Using administrative in- and outpatient records from Sweden, we apply a novel grouped…

General Economics · Economics 2022-05-05 Lena Janys , Bettina Siflinger

The three state illness death model has been established as a general approach for regression analysis of semi competing risks data. For observational data the marginal structural models (MSM) are a useful tool, under the potential outcomes…

Methodology · Statistics 2023-12-20 Yiran Zhang , Andrew Ying , Steve Edland , Lon White , Ronghui Xu

Reinforcement Learning (RL) agents deployed in real-world environments face degradation from sensor faults, actuator wear, and environmental shifts, yet lack intrinsic mechanisms to detect and diagnose these failures. We present an…

Artificial Intelligence · Computer Science 2025-09-15 Cameron Reid , Wael Hafez , Amirhossein Nazeri

Health is a very important prerequisite in peoples well-being and happiness. Several studies were more focused on presenting the occurrence on specific disease like forecasting the number of dengue and malaria cases. This paper utilized the…

Computers and Society · Computer Science 2021-01-06 Florence Jean B. Talirongan , Hidear Talirongan , Markdy Y. Orong

Estimation of stillbirth rates globally is complicated because of the paucity of reliable data from countries where most stillbirths occur. We compiled data and developed a Bayesian hierarchical temporal sparse regression model for…

Viewing the trajectory of a patient as a dynamical system, a recurrent neural network was developed to learn the course of patient encounters in the Pediatric Intensive Care Unit (PICU) of a major tertiary care center. Data extracted from…

Machine Learning · Statistics 2017-01-25 M Aczon , D Ledbetter , L Ho , A Gunny , A Flynn , J Williams , R Wetzel

Exposure to fine particulate matter ($PM_{2.5}$) poses significant health risks and accurately determining the shape of the relationship between $PM_{2.5}$ and health outcomes has crucial policy ramifications. While various statistical…

Applications · Statistics 2023-06-06 Michael Cork , Daniel Mork , Francesca Dominici

The primary analysis of randomized screening trials for cancer typically adheres to the intention-to-screen principle, measuring cancer-specific mortality reductions between screening and control arms. These mortality reductions result from…

Methodology · Statistics 2021-07-30 Sudipta Saha , Zhihui Liu , Olli Saarela

We develop a variable population age-structured ODE model to investigate the role of Intermittent Preventive Treatment (IPT) in averting malaria-induced mortalities in children, as well as its related cost in promoting the spread of…

Populations and Evolution · Quantitative Biology 2017-01-20 Carrie A. Manore , Miranda I. Teboh-Ewungkem , Olivia Prosper , Angela L. Peace , Katharine Gurski , Zhilan Feng

Improving health worldwide will require rigorous quantification of population-level trends in health status. However, global-level surveys are not available, forcing researchers to rely on fragmentary country-specific data of varying…

Methodology · Statistics 2014-05-20 Mariel M. Finucane , Christopher J. Paciorek , Goodarz Danaei , Majid Ezzati

Female breast cancer (FBC) incidence rate (IR) varies greatly by counties across the United States (US). Factors responsible for such high spatial disparities are not well understood, making it challenging to design effective intervention…

Applications · Statistics 2024-01-19 Tingting Zhao , Qing Han , Jinfeng Zhang

Mortality patterns at a subnational level or across subpopulations are often used to examine the health of a population. In small populations, however, death counts are erratic. To deal with this problem, demographers have proposed…

Methodology · Statistics 2023-03-21 Esther Denecke , Pavel Grigoriev , Roland Rau

We conducted a prospective analysis of incident dementia and its association with 65 sociodemographic, early-life, economic, health and behavioral, social, and genetic risk factors in a sample of 7,908 adults over the age of 50 from the…

Applications · Statistics 2021-01-27 Jordan Weiss , Eli Puterman , Aric A. Prather , Erin B. Ware , David H. Rehkopf