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There is growing consensus among neuroscientists that neural circuits critical for survival are the result of genomic decompression processes. We introduce SynaptoGen, a novel computational framework--member of the Connectome Models…
Calcium dynamics is the highly responsible for intracellular electrical (action potential) and chemical (neurotransmitter) signaling in neuron cell. The Mathematical modeling of calcium dynamics in neurons lead to the reaction diffusion…
In recent years, many molecular and environmental factors have been studied to understand how synaptic plasticity is modulated. Sleep, as an evolutionary conserved biological function, has shown to be a critical player for the consolidation…
Among various types of neuromorphic devices towards artificial intelligence, the electrochemical synaptic transistor emerges, in which the channel conductance is modulated by the insertion of ions according to the history of gate voltage…
Vision Transformers (ViTs) have demonstrated strong performance across a range of computer vision tasks by modeling long-range spatial interactions via self-attention. However, channel-wise mixing in ViTs remains static, relying on fixed…
Understanding how the collective physical processes drive robust morphological transitions in animal development requires the characterization of the relevant fields underlying morphogenesis. Calcium (Ca2+) is known to be such a field. Here…
In Diffusive Molecular Communication (DMC), information is transmitted by diffusing molecules. Synaptic signaling is a natural implementation of this paradigm. It is responsible for relaying information from one neuron to another, but also…
The studies described in this dissertation have attempted to address the cellular mechanisms of information storage by the brain. My work has focused primarily on the postsynaptic events that occur during and after induction of long-term…
How can memories be maintained from days to a lifetime, given turnover of proteins that underlie expression of long-term synaptic potentiation (LTP)? One likely solution relies on synaptic positive feedback loops, prominently including…
In the recent paper (2011) Faas and co-workers claimed that calmodulin could directly detect Ca2+ signals by acting as extremely fast calcium buffer. However the results and their interpretation raise serious doubts about this conclusion.
We present a mathematical model which explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained…
Contextual memory integration remains a high challenge in the development of language models, particularly in tasks that require maintaining coherence over extended sequences. Traditional approaches, such as self-attention mechanisms and…
Although syntactic information is beneficial for many NLP tasks, combining it with contextual information between words to solve the coreference resolution problem needs to be further explored. In this paper, we propose an end-to-end parser…
In this review paper, the theory of synaptic transmission (ST) was developed and discussed. We used the hypothesis of isomorphism between: (a) the cooperative behavior of mediators --- acetylcholine molecules (ACh) and cholinoreceptors in a…
Collective rhythmic dynamics from neurons is vital for cognitive functions such as memory formation but how neurons self-organize to produce such activity is not well understood. Attractor-based models have been successfully implemented as…
A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal…
Spiking Neural Networks (SNNs) emulate the integrated-fire-leak mechanism found in biological neurons, offering a compelling combination of biological realism and energy efficiency. In recent years, they have gained considerable research…
Synaptic connections in neuronal circuits are modulated by pre- and post-synaptic spiking activity. Heuristic models of this process of synaptic plasticity can provide excellent fits to results from in-vitro experiments in which pre- and…
Color fundus photography (CFP) is central to diagnosing and monitoring retinal disease, yet its acquisition variability (e.g., illumination changes) often degrades image quality, which motivates robust enhancement methods. Unpaired…
Sensors are the first element of the pathways that control the response of cells to their environment. After chemical, the next most important cue is mechanical, and protein complexes that produce or enable a chemical signal in response to…