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The processes that determine the establishment of the complex morphology of neurons during development are still poorly understood. We present experiments that use live imaging to examine the role of vesicle transport and propose a…

亚细胞过程 · 定量生物学 2019-08-07 Ina Humpert , Danila Di Meo , Andreas W. Püschel , Jan-Frederik Pietschmann

Improvements in technique in conjunction with an evolution of the theoretical and conceptual approach to neuronal networks provide a new perspective on living neurons in culture. Organization and connectivity are being measured…

无序系统与神经网络 · 物理学 2010-08-02 Jean-Pierre Eckmann , Ofer Feinerman , Leor Gruendlinger , Elisha Moses , Jordi Soriano , Tsvi Tlusty

How far is neuroepithelial cell proliferation in the developing central nervous system a deterministic process? Or, to put it in a more precise way, how accurately can it be described by a deterministic mathematical model? To provide tracks…

偏微分方程分析 · 数学 2010-05-04 Jean Clairambault , Vladimir Flores , Benoit Perthame , Melina Rapacioli , Edmundo Rofman , Rafael Verdes

Understanding the relation between cortical neuronal network structure and neuronal activity is a fundamental unresolved question in neuroscience, with implications to our understanding of the mechanism by which neuronal networks evolve…

The quintessential property of neuronal systems is their intensive patterns of selective synaptic connections. The current work describes a physics-based approach to neuronal shape modeling and synthesis and its consideration for the…

神经元与认知 · 定量生物学 2009-11-10 Luciano da Fontoura Costa , Regina Celia Coelho

Complex systems are successfully reduced to interacting elements via the network concept. Transport plays a key role in the survival of networks. For example the specialized signaling cascades of cellular networks filter noise and…

生物物理 · 物理学 2010-10-05 Robin Palotai , Peter Csermely

One major challenge of neuroscience is finding interesting structures in a seemingly disorganized neural activity. Often these structures have computational implications that help to understand the functional role of a particular brain…

神经元与认知 · 定量生物学 2023-09-01 Srdjan Ostojic , Stefano Fusi

The study of neuronal morphology is important not only for its potential relationship with neuronal dynamics, but also as a means to classify diverse types of cells and compare than among species, organs, and conditions. In the present…

神经元与认知 · 定量生物学 2024-03-11 Alexandre Benatti , Henrique F. de Arruda , Luciano da F. Costa

It is becoming increasingly appreciated that the signal transduction systems used by eukaryotic cells to achieve a variety of essential responses represent highly complex networks rather than simple linear pathways. While significant effort…

Vision Transformer models exhibit immense power yet remain opaque to human understanding, posing challenges and risks for practical applications. While prior research has attempted to demystify these models through input attribution and…

计算机视觉与模式识别 · 计算机科学 2025-04-10 Yifan Wang , Yifei Liu , Yingdong Shi , Changming Li , Anqi Pang , Sibei Yang , Jingyi Yu , Kan Ren

This article develops a fundamental insight into the behavior of neuronal membranes, focusing on their responses to stimuli measured with power spectra in the frequency domain. It explores the use of linear and nonlinear (quadratic…

神经元与认知 · 定量生物学 2023-12-04 Christophe Magnani , Lee E. Moore

The neural mechanism of memory has a very close relation with the problem of representation in artificial intelligence. In this paper a computational model was proposed to simulate the network of neurons in brain and how they process…

神经元与认知 · 定量生物学 2020-12-02 Hui Wei

Mounting evidence in neuroscience suggests the possibility of neuronal representations that individual neurons serve as the substrates of different mental representations in a point-to-point way. Combined with associationism, it can…

神经元与认知 · 定量生物学 2021-09-06 Chiyin Zheng

Intracellular transport is essential for maintaining proper cellular function in most eukaryotic cells, with perturbations in active transport resulting in several types of disease. Efficient delivery of critical cargos to specific…

生物物理 · 物理学 2016-08-16 David Ando , Nickolay Korabel , Kerwyn Casey Huang , Ajay Gopinathan

The predictive power of neural networks often costs model interpretability. Several techniques have been developed for explaining model outputs in terms of input features; however, it is difficult to translate such interpretations into…

机器学习 · 计算机科学 2017-08-17 Benjamin J. Lengerich , Sandeep Konam , Eric P. Xing , Stephanie Rosenthal , Manuela Veloso

Transport is an important function in many network systems and understanding its behavior on biological, social, and technological networks is crucial for a wide range of applications. However, it is a property that is not well-understood…

无序系统与神经网络 · 物理学 2009-11-13 Lazaros K. Gallos , Chaoming Song , Shlomo Havlin , Hernan A. Makse

From interacting cellular components to networks of neurons and neural systems, interconnected units comprise a fundamental organizing principle of the nervous system. Understanding how their patterns of connections and interactions give…

神经元与认知 · 定量生物学 2018-08-01 Danielle S. Bassett , Perry Zurn , Joshua I. Gold

The recent theoretical and experimental studies have revealed many details of signal propagation in nervous systems. In this paper an attempt is made to unify various mathematical models which describe the signal propagation in nerve…

生物物理 · 物理学 2016-01-11 Jüri Engelbrecht , Tanel Peets , Kert Tamm , Martin Laasmaa , Marko Vendelin

A growing body of research indicates that structural plasticity mechanisms are crucial for learning and memory consolidation. Starting from a simple phenomenological model, we exploit a mean-field approach to develop a theoretical framework…

神经元与认知 · 定量生物学 2024-06-19 Gianmarco Tiddia , Luca Sergi , Bruno Golosio

When inhibitory neurons constitute about 40% of neurons they could have an important antinociceptive role, as they would easily regulate the level of activity of other neurons. We consider a simple network of cortical spiking neurons with…

神经元与认知 · 定量生物学 2014-01-28 Fernando Montani , Emilia B. Deleglise , Osvaldo A. Rosso
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