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We reconsider the deterministic haploid mutation-selection equation with two types. This is an ordinary differential equation that describes the type distribution (forward in time) in a population of infinite size. This paper establishes…

概率论 · 数学 2020-09-25 Ellen Baake , Fernando Cordero , Sebastian Hummel

After its introduction in 1982, the Hopfield model has been extensively applied for classification and pattern recognition. Recently, its great potential in gene expression patterns retrieval has also been shown. Following this line, we…

定量方法 · 定量生物学 2019-02-07 Laura Cantini , Michele Caselle

Genetic fitness optimization using small populations or small population updates across generations generally suffers from randomly diverging evolutions. We propose a notion of highly probable fitness optimization through feasible…

神经与进化计算 · 计算机科学 2007-05-23 Paul Vitanyi

The fitness level method is a widely used technique for estimating the mean hitting time of elitist evolutionary algorithms on level-based fitness functions. However, this paper identifies its main limitation: the linear lower bound derived…

神经与进化计算 · 计算机科学 2026-03-17 Jun He , Siang Yew Chong , Xin Yao

This article deals with stochastic processes endowed with the Markov (memoryless) property and evolving over general (uncountable) state spaces. The models further depend on a non-deterministic quantity in the form of a control input, which…

系统与控制 · 计算机科学 2015-09-11 Sofie Haesaert , Robert Babuska , Alessandro Abate

A simple model of language evolution, proposed in \cite{K_N}, is characterized by a pay-off in communicative function, and by an error in learning, that measures the accuracy in language acquisition. In the mean field approximation, this…

物理与社会 · 物理学 2007-12-28 J M Tavares , M M Telo da Gama , A Nunes

Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a…

种群与进化 · 定量生物学 2015-06-19 Torsten Held , Armita Nourmohammad , Michael Lässig

Phenotypic evolution implies sequential fixations of new genomic sequences. The speed at which these mutations fixate depends, in part, on the relative fitness (selection coefficient) of the mutant vs. the ancestor. Using a simple…

种群与进化 · 定量生物学 2014-02-04 Sorin Tanase-Nicola , Ilya Nemenman

In this paper we study a class of stochastic individual-based models that describe the evolution of haploid populations where each individual is characterised by a phenotype and a genotype. The phenotype of an individual determines its…

概率论 · 数学 2017-08-07 Martina Baar , Anton Bovier

The impact of randomness on model training is poorly understood. How do differences in data order and initialization actually manifest in the model, such that some training runs outperform others or converge faster? Furthermore, how can we…

机器学习 · 计算机科学 2024-01-23 Michael Y. Hu , Angelica Chen , Naomi Saphra , Kyunghyun Cho

The ability of organisms to accurately sense their environment and respond accordingly is critical for evolutionary success. However, exactly how the sensory ability influences fitness is a topic of active research, while the necessity of a…

种群与进化 · 定量生物学 2020-11-11 Alexander S. Moffett , Nigel Wallbridge , Carrol Plummer , Andrew W. Eckford

We generalize the standard Hopfield model to the case when a weight is assigned to each input pattern. The weight can be interpreted as the frequency of the pattern occurrence at the input of the network. In the framework of the statistical…

无序系统与神经网络 · 物理学 2012-05-07 Iakov Karandashev , Boris Kryzhanovsky , Leonid Litinskii

We consider a non-conserving zero-range process with hopping rate proportional to the number of particles at each site. Particles are added to the system with a site-dependent creation rate, and removed from the system with a uniform…

统计力学 · 物理学 2019-09-04 Pascal Grange

Learning a Markov Decision Process (MDP) from a fixed batch of trajectories is a non-trivial task whose outcome's quality depends on both the amount and the diversity of the sampled regions of the state-action space. Yet, many MDPs are…

机器学习 · 计算机科学 2022-03-08 Giorgio Angelotti , Nicolas Drougard , Caroline P. C. Chanel

We propose a mathematical framework for natural selection in finite populations. Traditionally, many of the selection-based processes used to describe cultural and genetic evolution (such as imitation and birth-death models) have been…

种群与进化 · 定量生物学 2015-11-18 Alex McAvoy

Evolution on neutral networks of genotypes has been found in models to concentrate on genotypes with high mutational robustness, to a degree determined by the topology of the network. Here analysis is generalized beyond neutral networks to…

种群与进化 · 定量生物学 2015-09-01 Lee Altenberg

The Hopfield model in a transverse field is investigated in order to clarify how quantum fluctuations affect the macroscopic behavior of neural networks. Using the Trotter decomposition and the replica method, we find that the $\alpha$ (the…

凝聚态物理 · 物理学 2008-02-03 Yoshihiko Nonomura , Hidetoshi Nishimori

We consider the expected runtime of non-elitist evolutionary algorithms (EAs), when they are applied to a family of fitness functions with a plateau of second-best fitness in a Hamming ball of radius r around a unique global optimum. On one…

神经与进化计算 · 计算机科学 2020-08-20 Anton V. Eremeev

Mutational robustness quantifies the effect of random mutations on fitness. When mutational robustness is high, most mutations do not change fitness or have only a minor effect on it. From the point of view of fitness landscapes, robust…

种群与进化 · 定量生物学 2019-10-22 Alexander Klug , Su-Chan Park , Joachim Krug

The drift-barrier hypothesis states that random genetic drift constrains the refinement of a phenotype under natural selection. The influence of effective population size and the genome-wide deleterious mutation rate were studied…

种群与进化 · 定量生物学 2024-07-25 Luis A. La Rocca , Konrad Gerischer , Anton Bovier , Peter M. Krawitz