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We investigate a densely packed, non-random arrangement of forty-six chromosomes (46,XY) in human nuclei. Here, we model systems-level chromosomal crosstalk by unifying intrinsic parameters (chromosomal length and number of genes) across…

基因组学 · 定量生物学 2017-11-09 Sarosh N. Fatakia , Ishita S. Mehta , Basuthkar J. Rao

We propose a new type of SPDEs, singular or with regularized noises, motivated by a study of the fluctuation of the density field in a microscopic interacting particle system. They include a large scaling parameter $N$, which is the ratio…

概率论 · 数学 2024-12-03 Tadahisa Funaki

During hierarchical clustering, smaller masses generally collapse earlier than larger masses and so are denser on the average. The core of a small mass halo could be dense enough to resist disruption and survive undigested, when it is…

天体物理学 · 物理学 2009-10-31 Kandaswamy Subramanian , Renyue Cen , Jeremiah P. Ostriker

The large scale distribution of galaxies in the universe displays a complex pattern of clusters, super-clusters, filaments and voids with sizes limited only by the boundaries of the available samples. A quantitative statistical…

宇宙学与河外天体物理 · 物理学 2015-05-20 Francesco Sylos Labini , Luciano Pietronero

The flexibility of short DNA fragments is studied by a Hamiltonian model which treats the inter-strand and intra-strand forces at the level of the base pair. The elastic response of a set of homogeneous helices to externally applied forces…

生物大分子 · 定量生物学 2016-06-30 Marco Zoli

The sequence-dependent elasticity of double-helical DNA on a nm length scale can be captured by the rigid base-pair model, whose strains are the relative position and orientation of adjacent base-pairs. Corresponding elastic potentials have…

生物大分子 · 定量生物学 2013-05-29 Nils B. Becker , Ralf Everaers

We apply the scale-length method to several three dimensional samples of the Two degree Field Galaxy Redshift Survey. This method allows us to map in a quantitative and powerful way large scale structures in the distribution of galaxies…

天体物理学 · 物理学 2009-08-03 Francesco Sylos Labini , Nikolay L. Vasilyev , Yurij V. Baryshev

We propose to consider nonlinear fluctuations in the theory of liquid $^{4}$He deforming the commutation relations between the generalized coordinates and momenta. Generalized coordinates are coefficients of density fluctuations of Bose…

量子气体 · 物理学 2015-11-04 I. O. Vakarchuk , G. I. Panochko

The interplay between bending of the molecule axis and appearance of disruptions in circular DNA molecules, with $\sim 100$ base pairs, is addressed. Three minicircles with different radii and almost equal content of AT and GC pairs are…

软凝聚态物质 · 物理学 2014-06-03 Marco Zoli

Cellular processes do not follow deterministic rules; even in identical environments genetically identical cells can make random choices leading to different phenotypes. This randomness originates from fluctuations present in the…

分子网络 · 定量生物学 2016-02-02 Elijah Roberts , Shay Be'er , Chris Bohrer , Rati Sharma , Michael Assaf

The influence of decoherence and bonding on the linear conductance of single double-stranded DNA molecules is examined by fitting a phenomenological statistical model developed recently (EPJB {\bf 68}, 237 (2009)) to experimental results.…

软凝聚态物质 · 物理学 2010-09-30 M. Zilly , O. Ujsaghy , D. E. Wolf

Impact parameter dependent dipole models are ideal tools for investigating the spatial structure of the proton. We investigate the incoherent $ep$ cross section in exclusive $J/\psi$ photoproduction as measured by HERA, and find that as…

高能物理 - 唯象学 · 物理学 2022-09-28 Arjun Kumar , Tobias Toll

Complementary strands in DNA double helix show temporary fluctuational openings which are essential to biological functions such as transcription and replication of the genetic information. Such large amplitude fluctuations, known as the…

生物物理 · 物理学 2013-02-12 Marco Zoli

Genomic foundation models have the potential to decode DNA syntax, yet face a fundamental tradeoff in their input representation. Standard fixed-vocabulary tokenizers fragment biologically meaningful motifs such as codons and regulatory…

The structural properties of dense random packings of identical hard spheres (HS) are investigated. The bond order parameter method is used to obtain detailed information on the local structural properties of the system for different…

软凝聚态物质 · 物理学 2015-05-27 B. A. Klumov , S. A. Khrapak , G. E. Morfill

The large-scale distribution of cold dark matter halos is generally assumed to trace the large-scale distribution of matter. In a universe with multiple types of matter fluctuations, as is the case with massive neutrinos, the relation…

宇宙学与河外天体物理 · 物理学 2014-11-05 Marilena LoVerde

Phenotypic variation is a hallmark of cellular physiology. Metabolic heterogeneity, in particular, underpins single-cell phenomena such as microbial drug tolerance and growth variability. Much research has focussed on transcriptomic and…

分子网络 · 定量生物学 2019-01-31 Mona K. Tonn , Philipp Thomas , Mauricio Barahona , Diego A Oyarzún

We address the relation between long range correlations and charge transfer efficiency in aperiodic artificial or genomic DNA sequences. Coherent charge transfer through the HOMO states of the guanine nucleotide is studied using the…

介观与纳米尺度物理 · 物理学 2011-05-17 Stephan Roche , Dominique Bicout , Enrique Macia , Efim Kats

Supersonic turbulence results in strong density fluctuations in the interstellar medium (ISM), which have a profound effect on the chemical structure. Particularly useful probes of the diffuse ISM are the ArH$^+$, OH$^+$, H$_2$O$^+$…

星系天体物理 · 物理学 2019-11-12 Shmuel Bialy , David Neufeld , Mark Wolfire , Amiel Sternberg , Blakesley Burkhart

On large scales galaxies and their halos are usually assumed to trace the dark matter with a constant bias and dark matter is assumed to trace the linear density field. We test these assumption using several large N-body simulations with…

天体物理学 · 物理学 2009-11-10 Uros Seljak , Michael S. Warren