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We study theoretically the in vitro evolution of a DNA sequence by binding to a transcription factor. Using a simple model of protein-DNA binding and available binding constants for the Mnt protein, we perform large-scale, realistic…

凝聚态物理 · 物理学 2009-11-10 Morten Kloster , Chao Tang

We study competitive DNA sequence evolution directed by {\it in vitro} protein binding. The steady-state dynamics of this process is well described by a shape-preserving pulse which decelerates and eventually reaches equilibrium. We explain…

统计力学 · 物理学 2009-11-07 Weiqun Peng , Ulrich Gerland , Terence Hwa , Herbert Levine

We consider a model of cultural evolution for a strategy selection in a population of individuals who interact in a game theoretic framework. The evolution combines individual learning of the environment (population strategy profile),…

种群与进化 · 定量生物学 2020-06-03 Misha Perepelitsa

In this article we focus on evolving information systems. First a delimitation of the concept of evolution is provided, resulting in a first attempt to a general theory for such evolutions. The theory makes a distinction between the…

人工智能 · 计算机科学 2021-05-25 H. A. Proper , Th. P. van der Weide

We introduce an analytical model for population dynamics with intra-specific competition, mutation and assortative mating as basic ingredients. The set of equations that describes the time evolution of population size in a mean-field…

种群与进化 · 定量生物学 2015-06-26 V. Schwämmle , K. Luz-Burgoa , J. S. Sá Martins , S. Moss de Oliveira

The inheritance of characteristics induced by the environment has often been opposed to the theory of evolution by natural selection. Yet, while evolution by natural selection requires new heritable traits to be produced and transmitted, it…

种群与进化 · 定量生物学 2015-06-18 Olivier Rivoire , Stanislas Leibler

Identifying and characterizing mutational paths is an important issue in evolutionary biology and in bioengineering. We here introduce a generic description of mutational paths in terms of the goodness of sequences and of the mutational…

生物大分子 · 定量生物学 2023-03-29 Eugenio Mauri , Simona Cocco , Rémi Monasson

We consider the evolution of populations under the joint action of mutation and differential reproduction, or selection. The population is modelled as a finite-type Markov branching process in continuous time, and the associated…

种群与进化 · 定量生物学 2009-02-23 Ellen Baake , Hans-Otto Georgii

A model of genome evolution is proposed. Based on three assumptions the evolutionary theory of a genome is formulated. The general law on the direction of genome evolution is given. Both the deterministic classical equation and the…

其他定量生物学 · 定量生物学 2014-11-11 Liaofu Luo

The central goal of a dynamical theory of evolution is to abstract the mean evolutionary trajectory in the trait space by considering ecological processes at the level of the individual. In this work, we develop such a theory for a new…

种群与进化 · 定量生物学 2020-03-25 Vaibhav Madhok

Molecular traits, such as gene expression levels or protein binding affinities, are increasingly accessible to quantitative measurement by modern high-throughput techniques. Such traits measure molecular functions and, from an evolutionary…

种群与进化 · 定量生物学 2013-11-15 Armita Nourmohammad , Torsten Held , Michael Lässig

A dynamical theory for the evolution of the genetic code is presented, which accounts for its universality and optimality. The central concept is that a variety of collective, but non-Darwinian, mechanisms likely to be present in early…

种群与进化 · 定量生物学 2009-11-13 Kalin Vetsigian , Carl Woese , Nigel Goldenfeld

We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination and point mutations. The simplicity of the…

生物物理 · 物理学 2009-11-10 Weiqun Peng , Herbert Levine , Terence Hwa , David A. Kessler

Geographic ranges of communities of species evolve in response to environmental, ecological, and evolutionary forces. Understanding the effects of these forces on species' range dynamics is a major goal of spatial ecology. Previous…

种群与进化 · 定量生物学 2022-02-02 Farshad Shirani , Judith R. Miller

A historical dispute in the conceptual underpinnings of evolution is the validity of the gene centered view of evolution. \cite{dawkins,lewontin} We transcend this debate by formalizing the gene centered view as a dynamic version of the…

生物物理 · 物理学 2007-05-23 Y. Bar-Yam

We propose a class of evolutionary models that involves an arbitrary exchangeable process as the breeding process and different selection schemes. In those models, a new genome is born according to the breeding process, and then a genome is…

神经与进化计算 · 计算机科学 2020-08-25 Jüri Lember , Chris Watkins

The basic mechanics of evolution have been understood since Darwin. But debate continues over whether macroevolutionary phenomena are driven primary by the fitness structure of genotype space or by ecological interaction. In this paper we…

种群与进化 · 定量生物学 2012-10-22 David V. Foster , Mary M. Rorick , Tanja Gesell , Laura Feeney , Jacob G. Foster

This paper aims to the conditions of traffic flow evolving to stability and the stability of equilibrium under demand time-varying of traffic networks. The general framework of the evolution of flow dynamics by adopting evolutionary game…

物理与社会 · 物理学 2018-07-26 Xingguang Chen

The spread of an epidemic disease and the population's collective behavioural response are deeply intertwined, influencing each other's evolution. Such a co-evolution typically has been overlooked in mathematical models, limiting their…

动力系统 · 数学 2024-10-24 Kathinka Frieswijk , Lorenzo Zino , Mengbin Ye , Alessandro Rizzo , Ming Cao

One of the most intriguing questions in evolution is how organisms exhibit suitable phenotypic variation to rapidly adapt in novel selective environments which is crucial for evolvability. Recent work showed that when selective environments…

种群与进化 · 定量生物学 2015-08-28 Kostas Kouvaris , Jeff Clune , Louis Kounios , Markus Brede , Richard A. Watson
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