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In the growth of bacterial colonies, a great variety of complex patterns are observed in experiments, depending on external conditions and the bacterial species. Typically, existing models employ systems of reaction-diffusion equations or…

生物物理 · 物理学 2019-11-12 Lautaro Vassallo , David Hansmann , Lidia A. Braunstein

We introduce a stochastic cellular automaton as a model for culture and border formation. The model can be conceptualized as a game where the expansion rate of cultures is quantified in terms of their area and perimeter in such a way that…

物理与社会 · 物理学 2023-11-09 Frederik Ravn Klausen , Asbjørn Bækgaard Lauritsen

A one-dimensional cellular automaton with a probabilistic evolution rule can generate stochastic surface growth in $(1 + 1)$ dimensions. Two such discrete models of surface growth are constructed from a probabilistic cellular automaton…

统计力学 · 物理学 2015-06-25 Pratip Bhattacharyya

A hallmark of bacterial populations cultured in vitro is their homogeneity of growth, where the majority of cells display identical growth rate, cell size and content. Recent insights, however, have revealed that even cells growing in…

定量方法 · 定量生物学 2022-06-07 Santosh Pandey , Yunsoo Park , Ankita Ankita , Gregory J. Phillips

A key problem toward the use of microorganisms as bio-factories is reaching and maintaining cellular communities at a desired density and composition so that they can efficiently convert their biomass into useful compounds. Promising…

系统与控制 · 电气工程与系统科学 2023-12-18 Sara Maria Brancato , Davide Salzano , Francesco De Lellis , Davide Fiore , Giovanni Russo , Mario di Bernardo

Bacterial cellulose biofilms are complex networks of strong interwoven nanofibers that control transport and protect bacterial colonies in the film. Design of diverse applications of bacterial cellulose films also relies on understanding…

软凝聚态物质 · 物理学 2022-06-09 Firoozeh Babayekhorasani , Maryam Hosseini , Patrick T. Spicer

Advances in synthetic biology allow us to engineer bacterial collectives with pre-specified characteristics. However, the behavior of these collectives is difficult to understand, as cellular growth and division as well as extra-cellular…

细胞行为 · 定量生物学 2017-09-13 James J. Winkle , Oleg Igoshin , Matthew R. Bennett , Krešimir Josić , William Ott

Continuum models for the spatial dynamics of growing cell populations have been widely used to investigate the mechanisms underpinning tissue development and tumour invasion. These models consist of nonlinear partial differential equations…

组织与器官 · 定量生物学 2019-07-15 Mark AJ Chaplain , Tommaso Lorenzi , Fiona R Macfarlane

For the first time the phenomenon of cellular structure coarsening are consistently analysed from the positions of kinetic, hydrodynamic and stochastodynamic theories of nonequilibrium statistical systems. Thereby micro-, meso- and…

凝聚态物理 · 物理学 2015-06-25 S. B. Goryachev

The mechanism of bacterial cell size control has been a mystery for decades, which involves the well-coordinated growth and division in the cell cycle. The revolutionary modern techniques of microfluidics and the advanced live imaging…

统计力学 · 物理学 2021-08-30 Liang Luo , Yang Bai , Xiongfei Fu

The evolutionary success of bacteria lies in their ability to form complex surface-associated communities in diverse biophysical settings. However, it remains poorly understood how compliance of soft surfaces, measured in terms of their…

软凝聚态物质 · 物理学 2025-08-05 Garima Rani , Anupam Sengupta

We introduce a general theoretical framework to study the shape dynamics of actively growing and remodeling surfaces. Using this framework we develop a physical model for growing bacterial cell walls and study the interplay of cell shape…

生物物理 · 物理学 2016-04-08 Shiladitya Banerjee , Norbert F. Scherer , Aaron R. Dinner

The dynamics of growth of bacterial populations has been extensively studied for planktonic cells in well-agitated liquid culture, in which all cells have equal access to nutrients. In the real world, bacteria are more likely to live in…

种群与进化 · 定量生物学 2017-11-01 Xinxian Shao , Andrew Mugler , Justin Kim , Ha Jun Jeong , Bruce Levin , Ilya Nemenman

Biofilms are bacterial aggregates that grow on moist surfaces. Thin homogeneous biofilms naturally formed on the walls of conducts may serve as biosensors, providing information on the status of microsystems (MEMS) without disrupting them.…

软凝聚态物质 · 物理学 2024-01-17 Ana Carpio , Baldvin Einarsson , David R. Espeso

To explore the coupling between a growing population of microorganisms such as E. coli and a nonuniform nutrient distribution, we formulate a minimalistic model. It consists of active Brownian particles that divide and grow at a…

生物物理 · 物理学 2024-01-11 Till Welker , Holger Stark

Bacteria are prolific at colonizing diverse surfaces under a widerange of environmental conditions, and exhibit fascinating examples of self-organization across scales. Though it has recently attracted considerable interest, the role of…

软凝聚态物质 · 物理学 2024-03-25 M. T. Khan , J. Cammann , A. Sengupta , E. Renzi , M. G. Mazza

High-throughput experimental techniques and bioinformatics tools make it possible to obtain reconstructions of the metabolism of microbial species. Combined with mathematical frameworks such as flux balance analysis, which assumes that…

Bacteria are ubiquitous in our daily lives, either as motile planktonic cells or as immobilized surface-attached biofilms. These different phenotypic states play key roles in agriculture, environment, industry, and medicine; hence, it is…

种群与进化 · 定量生物学 2021-12-07 Jenna A. Ott , Selena Chiu , Daniel B. Amchin , Tapomoy Bhattacharjee , Sujit S. Datta

Biofilms are bacterial aggregates encased in a self-produced polymeric matrix which attach to moist surfaces and are extremely resistant to chemicals and antibiotics. Recent experiments show that their structure is defined by the interplay…

软凝聚态物质 · 物理学 2024-01-17 Ana Carpio , Elena Cebrian , Perfecto Vidal

Protein distributions measured under a broad set of conditions in bacteria and yeast were shown to exhibit a common skewed shape, with variances depending quadratically on means. For bacteria these properties were reproduced by temporal…

生物物理 · 物理学 2015-10-28 Naama Brenner , C. M. Newman , Dino Osmanovic , Yitzhak Rabin , Hanna Salman , D. L. Stein