相关论文: RNA secondary structure design

Meta-learning of numerical algorithms for a given task consists of the data-driven identification and adaptation of an algorithmic structure and the associated hyperparameters. To limit the complexity of the meta-learning problem, neural…

Neural architecture search (NAS) searches architectures automatically for given tasks, e.g., image classification and language modeling. Improving the search efficiency and effectiveness have attracted increasing attention in recent years.…

Motivation :Reconstructing the topology of a gene regulatory network is one of the key tasks in systems biology. Despite of the wide variety of proposed methods, very little work has been dedicated to the assessment of their stability…

Searching for the architecture cells is a dominant paradigm in NAS. However, little attention has been devoted to the analysis of the cell-based search spaces even though it is highly important for the continual development of NAS. In this…

We consider Convolutional Neural Networks (CNNs) with 2D structured features that are symmetric in the spatial dimensions. Such networks arise in modeling pairwise relationships for a sequential recommendation problem, as well as secondary…

While generalizing well over natural inputs, neural networks are vulnerable to adversarial inputs. Existing defenses against adversarial inputs have largely been detached from the real world. These defenses also come at a cost to accuracy.…

An archetypal problem discussed in computer science is the problem of searching for a given number in a given set of numbers. Other than sequential search, the classic solution is to sort the list of numbers and then apply binary search.…

In this paper we study properties of topological RNA structures, i.e.~RNA contact structures with cross-serial interactions that are filtered by their topological genus. RNA secondary structures within this framework are topological…

Artificial synthesis of DNA molecules is an essential part of the study of biological mechanisms. The design of a synthetic DNA molecule usually involves many objectives. One of the important objectives is to eliminate short sequence…

In post-transcriptional regulation, an mRNA molecule is bound by many proteins and/or miRNAs to modulate its function. To enable combinatorial gene regulation, these binding partners of an RNA must communicate with each other, exhibiting…

RNA's diverse biological functions stem from its structural versatility, yet accurately predicting and designing RNA sequences given a 3D conformation (inverse folding) remains a challenge. Here, I introduce a deep learning framework that…

Conformational entropy for atomic-level, three dimensional biomolecules is known experimentally to play an important role in protein-ligand discrimination, yet reliable computation of entropy remains a difficult problem. Here we describe…

We study genetic networks that produce many species of non-coding RNA molecules that are present at a moderate density, as typically exists in the cell. The associations of the many species of these RNA are modeled physically, taking into…

DNA data storage systems encode digital data into DNA strands, enabling dense and durable storage. Efficient data retrieval depends on coverage depth, a key performance metric. We study the random access coverage depth problem and focus on…

Independent of the technology, it is generally expected that future nanoscale devices will be built from vast numbers of densely arranged devices that exhibit high failure rates. Other than that, there is little consensus on what type of…

In this paper we study the structure of specific linear codes called DNA codes. The first attempts on studying such codes have been proposed over four element rings which are naturally matched with DNA four letters. Later, double (pair) DNA…

Reversibility is a key issue in the interface between computation and physics, and of growing importance as miniaturization progresses towards its physical limits. Most foundational work on reversible computing to date has focussed on…

To defend deep neural networks from adversarial attacks, adversarial training has been drawing increasing attention for its effectiveness. However, the accuracy and robustness resulting from the adversarial training are limited by the…

We study the richness of the ensemble of graphical structures (i.e., unlabeled graphs) of the one-dimensional random geometric graph model defined by $n$ nodes randomly scattered in $[0,1]$ that connect if they are within the connection…

Binary Convolutional Neural Networks (CNNs) have significantly reduced the number of arithmetic operations and the size of memory storage needed for CNNs, which makes their deployment on mobile and embedded systems more feasible. However,…