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Molecular motor proteins form the basis of cellular dynamics. Recently, notable efforts have led to the creation of their DNA-based mimics, which can carry out complex nanoscale motion. However, such functional analogues have not yet been…

In living systems, DNA undergoes continuous and rhythmic mechanical remodeling through condensation, looping, and disentangling to regulate gene expression, segregate chromosomes, and guide morphogenesis. Here, we demonstrate a purely…

软凝聚态物质 · 物理学 2025-12-01 Maya Levanon , Noa S. Goldberg , Dvir Cohen , Eran Bouchbinder , Ram M. Adar , Alexandra M. Tayar

A water monolayer squeezed between two solid planes experiences strong out-of-plane confinement effects while expanding freely within the plane. As a consequence, the transport of such two-dimensional water combines hydrodynamic and…

材料科学 · 物理学 2023-07-06 Maxim Trushin , Alexandra Carvalho , A. H. Castro Neto

Double-stranded DNA translocates through sufficiently large nanopores either in a linear, single-file fashion or in a folded hairpin conformation when captured somewhere along its length. We show that the folding state of DNA can be…

生物物理 · 物理学 2018-08-15 Niklas Ermann , Nikita Hanikel , Vivian Wang , Kaikai Chen , Ulrich F. Keyser

We consider voltage-driving DNA translocation through a nanopore in the present study. By assuming the DNA is coaxial with the cylindrical nanopore, a hydrodynamic model for determining effective force on a single DNA molecule in a nanopore…

软凝聚态物质 · 物理学 2013-06-19 Wen-Yue Tang , Guo-Hui Hu

The world of nanoscales in fluidics is the frontier where the continuum of fluid mechanics meets the atomic, and even quantum, nature of matter. While water dynamics remains largely classical under extreme confinement, several experiments…

介观与纳米尺度物理 · 物理学 2025-01-03 Baptiste Coquinot , Anna T. Bui , Damien Toquer , Angelos Michaelides , Nikita Kavokine , Stephen J. Cox , Lydéric Bocquet

The behavior of long DNA molecules in a cell-sized confined space was investigated. We prepared water-in-oil droplets covered by phospholipids, which mimic the inner space of a cell, following the encapsulation of DNA molecules with…

生物物理 · 物理学 2015-04-14 T. Hamada , R. Fujimoto , S. F. Shimobayashi , M. Ichikawa , M. Takagi

Strong influence of water molecules on the transport and magnetic properties of DNA, observed in this study, opens up real opportunities for application of DNA in molecular electronics. Interaction of the nucleobases with water molecules…

化学物理 · 物理学 2010-08-13 Julia Berashevich , Tapash Chakraborty

The properties of liquid water are known to change drastically in confined geometries. A most interesting and intriguing phenomenon is that the diffusion of water is found to be strongly enhanced by the proximity of a hydrophobic confining…

软凝聚态物质 · 物理学 2024-12-06 Lorenzo Agosta , Kersti Hermansson , Mikhail Dzugutov

DNA-interacting proteins have roles multiple processes, many operating as molecular machines which undergo dynamic metastable transitions to bring about their biological function. To fully understand this molecular heterogeneity, DNA and…

生物大分子 · 定量生物学 2015-04-15 Adam J. M. Wollman , Helen Miller , Zhaokun Zhou , Mark C. Leake

Flow-driven rotary motors drive functional processes in human society such as windmills and water wheels. Although examples of such rotary motors also feature prominently in cell biology, their synthetic construction at the nanoscale has…

The structure of liquid water in the proximity of an interface can deviate significantly from that of bulk water, with surface-induced structural perturbations typically converging to bulk values at about ~1 nm from the interface. While…

软凝聚态物质 · 物理学 2022-03-01 Piero Gasparotto , Martin Fitzner , Stephen J. Cox , Gabriele Cesare Sosso , Angelos Michaelides

The dynamics of the structured water molecules in the hydration shell of the DNA double helix is of paramount importance for the understanding of many biological mechanisms. In particular, the vibrational dynamics of a water spine that is…

生物大分子 · 定量生物学 2020-12-09 T. L. Bubon , S. M. Perepelytsya

Dimensions and molecular structure play pivotal roles in the principle of heat conduction. The dimensional characteristics of solution within nanoscale systems depend on the degrees of confinement. However, the influence of such variations…

软凝聚态物质 · 物理学 2024-05-14 Shun Imamura , Yusei Kobayashi , Eiji Yamamoto

The motion of the three-phase contact line between two immiscible fluids and a solid surface arises in a variety of wetting phenomena and technological applications. One challenge in continuum theory is the effective representation of…

The morphology of DNA is strongly influenced by its surrounding environment, including factors such as pH, salt type and valency, and the presence of polymers. Inorganic salts are known to reduce the DNA chain length through mechanisms like…

软凝聚态物质 · 物理学 2026-03-03 Anuj Chhabra , Sandip Mandal , Yugang Zhang , Oleg Gang , Prabal K. Maiti , Sunita Srivastava

The relation between the frequency-dependent friction of a molecule in a liquid and the hydrodynamic properties of the liquid is fundamental for molecular dynamics. We investigate this connection for a water molecule moving in liquid water…

软凝聚态物质 · 物理学 2024-08-23 Henrik Kiefer , Domenico Vitali , Benjamin A. Dalton , Laura Scalfi , Roland R. Netz

For an accurate description of nanofluidic systems, it is crucial to account for the transport properties of liquids at surfaces on sub-nanometer scales, where classical hydrodynamics fails due to the finite range of surface-liquid…

软凝聚态物质 · 物理学 2025-10-07 Shane R. Carlson , Roland R. Netz

Unusually high bending flexibility has been recently reported for DNA on short length scales. We use atomic force microscopy (AFM) in solution to obtain a direct estimate of DNA bending statistics for scales down to one helical turn. It…

生物大分子 · 定量生物学 2014-07-22 Alexey K. Mazur , Mounir Maaloum

Motivated by recent experiments we have studied the optical conductivity of DNA in its natural environment containing water molecules and counter ions. Our density functional theory calculations (using SIESTA) for four base pair B-DNA with…

软凝聚态物质 · 物理学 2009-11-11 A. Huebsch , R. G. Endres , D. L. Cox , R. R. P. Singh