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We present a method of detecting sequence defects by supercoiling DNA with magnetic tweezers. The method is sensitive to a single mismatched base pair in a DNA sequence of several thousand base pairs. We systematically compare DNA molecules…

生物大分子 · 定量生物学 2017-10-11 Andrew Dittmore , Sumitabha Brahmachari , Yasuhara Takagi , John F. Marko , Keir C. Neuman

It has recently been shown that in some DNA microarrays the time needed to reach thermal equilibrium may largely exceed the typical experimental time, which is about 15h in standard protocols (Hooyberghs et al. Phys. Rev. E 81, 012901…

生物大分子 · 定量生物学 2012-03-22 Jean-Charles Walter , K. Myriam Kroll , Jef Hooyberghs , Enrico Carlon

The chromatin fiber is a complex of DNA and specific proteins called histones forming the first structural level of organization of eukaryotic chromosomes. In tightly organized chromatin fibers, the short segments of naked DNA linking the…

统计力学 · 物理学 2016-08-16 Jean-Marc Victor , Eli Ben-Haïm , Annick Lesne

There is so far no clear-cut experimental analysis that can determine whether dipole-dipole interactions enhance or reduce the blocking temperature $T_{B}$ of nanoparticle assemblies. It seems that the samples play a central role in the…

介观与纳米尺度物理 · 物理学 2019-07-12 F. Vernay , H. Kachkachi

A unique property of metal nanoclusters is the "superatom" shell structure of their delocalized electrons. The electronic shell levels are highly degenerate and therefore represent sharp peaks in the density of states. This can enable…

超导电性 · 物理学 2015-12-17 Avik Halder , Vitaly V. Kresin

Loops are essential secondary structure elements in folded DNA and RNA molecules and proliferate close to the melting transition. Using a theory for nucleic acid secondary structures that accounts for the logarithmic entropy c ln m for a…

统计力学 · 物理学 2011-05-02 Thomas R. Einert , Henri Orland , Roland R. Netz

The thermal conductivity of double-stranded (ds) B-DNA was systematically investigated using classical molecular dynamics (MD) simulations. The effect of changing base-pairs on the thermal conductivity of dsDNA, needed investigation at a…

计算物理 · 物理学 2021-05-03 Vignesh Mahalingam , Dineshkumar Harursampath

Anomalous non-exponential relaxation in hydrated biomolecules is commonly attributed to the complexity of the free-energy landscapes, similarly to polymers and glasses. It was found recently that the hydrogen-bond breathing of terminal DNA…

生物大分子 · 定量生物学 2017-07-05 Alexey K. Mazur

In search for novel nematic materials, a laterally linked H-shaped liquid crystal dimer have been synthesized and characterized. The distinct feature of the material is a very broad temperature range (about 50 oC) of the nematic phase,…

The effect of disorder on flux line lattice (FLL) melting is studied via the Peak Effect phenomenon. On the upper branch of the Peak Effect curve, where this effect is more robust, we observe a stepwise disordering of the FLL, suggesting…

超导电性 · 物理学 2008-02-03 S. S. Banerjee

We study a class of micromanipulation experiments, exemplified by the pulling apart of the two strands of double-stranded DNA (dsDNA). When the pulling force is increased to a critical value, an ``unzipping'' transition occurs. For random…

软凝聚态物质 · 物理学 2009-10-31 David K. Lubensky , David R. Nelson

DNA hybridization is a fundamental reaction with wide-ranging applications in biotechnology. The nearest-neighbor (NN) model provides the most reliable description of the energetics of duplex formation. Most DNA thermodynamics studies have…

生物大分子 · 定量生物学 2024-04-30 Paolo Rissone , Marc Rico-Pasto , Steve Smith , Felix Ritort

In many biopolymer solutions, attractive interactions that stabilize finite-sized clusters at low concentrations also promote phase separation at high concentrations. Here we study a model biopolymer system that exhibits the opposite…

软凝聚态物质 · 物理学 2024-07-31 Omkar Hegde , Tianhao Li , Anjali Sharma , Marco Borja , William M. Jacobs , W. Benjamin Rogers

We present results of a numerical mean field treatment of interacting spins and carriers in doped diluted magnetic semiconductors, which takes into account the positional disorder present in these alloy systems. Disorder is found to enhance…

无序系统与神经网络 · 物理学 2009-10-31 Mona Berciu , R. N. Bhatt

We use state-of-the-art molecular dynamics simulations to study the effects of annealed disorder on the phase separating kinetics and aging phenomena of a segregating binary fluid mixture. In the presence of disorder, we observe a dramatic…

软凝聚态物质 · 物理学 2021-12-01 Rounak Bhattacharyya , Bhaskar Sen Gupta

As sections of a strand duplexed DNA denature when exposed to high temperature, the excess linking number is taken up by the undenatured portions of the molecule. The mechanical energy that arises because of the overwinding of the…

软凝聚态物质 · 物理学 2009-11-07 Joseph Rudnick , Robijn Bruinsma

We use a recently developed coarse-grained model to simulate the overstretching of duplex DNA. Overstretching at 23C occurs at 74 pN in the model, about 6-7 pN higher than the experimental value at equivalent salt conditions. Furthermore,…

生物大分子 · 定量生物学 2013-06-25 Flavio Romano , Debayan Chakraborty , Jonathan P. K. Doye , Thomas E. Ouldridge , Ard. A. Louis

We present a detailed molecular-dynamics study of the melting, freezing, and coalescence of gold nanoclusters within the framework of the embedded-atom method. Concerning melting, we find the process to first affect the surface…

材料科学 · 物理学 2009-10-30 Laurent J. Lewis , Pablo Jensen , Jean-Louis Barrat

We study melting in a two-dimensional system of classical particles with Gaussian-core interactions in disordered environments. The pure system validates the conventional two-step melting with a hexatic phase intervening between the solid…

软凝聚态物质 · 物理学 2023-08-01 Prashanti Jami , Pinaki Chaudhuri , Chandan Dasgupta , Amit Ghosal

The stability and dynamics of a double-stranded DNA (dsDNA) is affected by the preferential occupancy of small monovalent molecular ions. Small metal and molecular ions such as sodium and alkyl ammonium have crucial biological functions in…

软凝聚态物质 · 物理学 2015-08-25 Soumadwip Ghosh , Mayank Kumar Dixit , Rajarshi Chakrabarti