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We develop a continuum theory to describe the collective dynamics of deformable epithelial cells, using two tensor order parameters to distinguish the force-generating active filaments in the cells from their shape. The theory demonstrates…

软凝聚态物质 · 物理学 2025-01-13 Mehrana R. Nejad , Julia M. Yeomans , Sumesh P Thampi

Accurate predictions of charge excitation energies of molecules in the disordered condensed phase are central to the chemical reactivity, stability, and optoelectronic properties of molecules and critically depend on the specific…

化学物理 · 物理学 2021-08-25 Guorong Weng , Vojtech Vlcek

A novel electromagnetic particle-in-cell algorithm has been developed for fully kinetic plasma simulations on unstructured (irregular) meshes in complex body-of-revolution geometries. The algorithm, implemented in the BORPIC++ code,…

数值分析 · 数学 2024-05-16 Dong-Yeop Na , Fernando L. Teixeira , Yuri A. Omelchenko

Mathematical models come in many forms across biological applications. In the case of complex, spatial dynamics and pattern formation, stochastic models also face two main challenges: pattern data is largely qualitative, and model…

细胞行为 · 定量生物学 2022-12-26 Electa Cleveland , Angela Zhu , Bjorn Sandstede , Alexandria Volkening

Interface equations are derived for both binary diffusive and binary fluid systems subjected to non-equilibrium conditions, starting from the coarse-grained (mesoscopic) models. The equations are used to describe thermo-capillary motion of…

软凝聚态物质 · 物理学 2015-06-25 Ravi Bhagavatula , David Jasnow , Takao Ohta

Micro-calorimetry offers significant potential as a quantitative method for studying the structure and function of biological systems, for instance, by probing the excess heat released by cellular or sub-cellular structures, isothermal or…

生物物理 · 物理学 2026-02-18 Faezeh Khodabandehlou , Christian Maes , Édgar Roldán

Phase separation and transitions among different molecular states are ubiquitous in living cells. Such transitions can be governed by local equilibrium thermodynamics or by active processes controlled by biological fuel. It remains largely…

生物物理 · 物理学 2021-11-24 G. Bartolucci , O. Adame-Arana , X. Zhao , C. A. Weber

Biomembranes play a central role in various phenomena like locomotion of cells, cell-cell interactions, packaging of nutrients, and in maintaining organelle morphology and functionality. During these processes, the membranes undergo…

We consider the thermal dunking problem, in which a solid body is suddenly immersed in a fluid of different temperature, and study both the temporal evolution of the solid and the associated Biot number -- a non-dimensional heat transfer…

计算工程、金融与科学 · 计算机科学 2025-11-11 Theron Guo , Kento Kaneko , Claude Le Bris , Anthony T. Patera

Topological quantum computing is a way of allowing precise quantum computations to run on noisy and imperfect hardware. One implementation uses surface codes created by forming defects in a highly-entangled cluster state. Such a method of…

量子物理 · 物理学 2020-01-14 Dominic Horsman

Our understanding of the physics of biological molecules, such as proteins and DNA, is limited because the approximations we usually apply to model inert materials are not in general applicable to soft, chemically inhomogeneous systems. The…

量子物理 · 物理学 2010-07-13 Sarah Harris , Vivien M. Kendon

Topological defects are fundamental to the collective dynamics of non-equilibrium systems and in active matter, mediating spontaneous flows, dynamic self-organization, and emergent pattern formation. Here, we reveal critical states in…

In living systems, collective molecular behavior is driven by thermodynamic forces in the form of chemical gradients. Leveraging recent advances in the field of nonequilibrium physics, I show that increasing the thermodynamic force alone…

亚细胞过程 · 定量生物学 2022-09-21 Milo M. Lin

A longstanding challenge in nonequilibrium thermodynamics is to predict the emergence of self-organized behaviours and functionalities typical of living matter. Despite the progress with classical complex systems, it remains far from…

量子物理 · 物理学 2022-01-13 Thiago Werlang , Maurício Matos , Frederico Brito , Daniel Valente

Cell blebs are protrusions of the cell membrane and can be instrumental for cell migration. We derive a continuum model for the mechanical and geometrical aspects of the onset of blebbing in terms of a force balance. It is abstract and…

数值分析 · 数学 2020-03-03 Björn Stinner , Andreas Dedner , Adam Nixon

Polymers with active segments constitute prospective future materials and are used as a model for some biological systems such as chromatin. The directions of the active forces are typically introduced with temporal or spatial correlations…

软凝聚态物质 · 物理学 2024-11-25 Adam H. T. P. Höfler , Iurii Chubak , Christos N. Likos , Jan Smrek

The living cell expends energetic and material resources to reliably process information from its environment. To do so, it utilises unreliable molecular circuitry that is subject to thermal and other fluctuations. Here, we argue that…

软凝聚态物质 · 物理学 2022-04-12 Kabir Husain , Sriram Ramaswamy , Madan Rao

Flux balance analysis has proven an effective tool for analyzing metabolic networks. In flux balance analysis, reaction rates and optimal pathways are ascertained by solving a linear program, in which the growth rate is maximized subject to…

最优化与控制 · 数学 2018-04-10 Amir Akbari , Paul I. Barton

Topological invariants have proved useful for analyzing emergent function as they characterize a property of the entire system, and are insensitive to local details, disorder, and noise. They support boundary states, which reduce the system…

统计力学 · 物理学 2025-10-10 Jaime Agudo-Canalejo , Evelyn Tang

The complex spatiotemporal flow patterns in living tissues, driven by active forces, have many of the characteristics associated with inertial turbulence even though the Reynolds number is extremely low. Analyses of experimental data from…

软凝聚态物质 · 物理学 2022-11-29 Xin Li , Sumit Sinha , T. R. Kirkpatrick , D. Thirumalai