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Protein structure prediction and folding are fundamental to understanding biology, with recent deep learning advances reshaping the field. Diffusion-based generative models have revolutionized protein design, enabling the creation of novel…

机器学习 · 计算机科学 2025-10-01 Yogesh Verma , Markus Heinonen , Vikas Garg

There is increasing interest in the analysis of biological tissue, its organization and its dynamics with the help of mathematical models. In the ideal case emergent properties on the tissue scale can be derived from the cellular scale.…

组织与器官 · 定量生物学 2009-11-13 Tilo Beyer , Michael Meyer-Hermann

Nonequilibrium states of quantum materials can exhibit exotic properties and enable unprecedented functionality and applications. These transient states are inherently inhomogeneous, characterized by the formation of topologically protected…

Topological defects in active polar fluids exhibit complex dynamics driven by internally generated stresses, reflecting the deep interplay between topology, flow, and non-equilibrium hydrodynamics. Feedback control offers a powerful means…

软凝聚态物质 · 物理学 2025-07-28 Abhinav Singh , Petros Koumoutsakos

Cellular bioelectricity describes the biological phenomenon in which cells in living tissue generate and maintain patterns of voltage gradients induced by differing concentrations of charged ions. A growing body of research suggests that…

分布式、并行与集群计算 · 计算机科学 2018-09-27 Seth Gilbert , James Maguire , Calvin Newport

Topological defects are at the root of the large-scale organization of liquid crystals. In two-dimensional active nematics, two classes of topological defects of charges $\pm 1/2$ are known to play a major role due to active stresses.…

软凝聚态物质 · 物理学 2022-04-08 Louis Brézin , Thomas Risler , Jean-François Joanny

We consider the problem of inferring the probability distribution of flux configurations in metabolic network models from empirical flux data. For the simple case in which experimental averages are to be retrieved, data are described by a…

分子网络 · 定量生物学 2017-04-27 Daniele De Martino , Andrea De Martino

A model computational quantum thermodynamic network is constructed with two variable temperature baths coupled by a linker system, with an asymmetry in the coupling of the linker to the two baths. It is found in computational simulations…

统计力学 · 物理学 2021-11-10 Phillip C. Lotshaw , Michael E. Kellman

We use extensive computer simulations to probe local thermodynamic equilibrium (LTE) in a quintessential model fluid, the two-dimensional hard-disks system. We show that macroscopic LTE is a property much stronger than previously…

统计力学 · 物理学 2015-09-16 J. J. del Pozo , P. L. Garrido , P. I. Hurtado

Quantum thermodynamics allows for the interconversion of quantum coherence and mechanical work. Quantum coherence is thus a potential physical resource for quantum machines. However, formulating a general nonequilibrium thermodynamics of…

量子物理 · 物理学 2025-11-05 Franklin L. S. Rodrigues , Eric Lutz

The scalability of photonic implementations of fault-tolerant quantum computing based on Gottesman-Kitaev-Preskill (GKP) qubits is injured by the requirements of inline squeezing and reconfigurability of the linear optical network. In this…

Flow networks are essential for both living organisms and enginneered systems. These networks often present complex dynamics controlled, at least in part, by their topology. Previous works have shown that topologically complex networks…

软凝聚态物质 · 物理学 2020-03-24 Miguel Ruiz-Garcia , Eleni Katifori

Molecular biology and biochemistry interpret microscopic processes in the living world in terms of molecular structures and their interactions, which are quantum mechanical by their very nature. Whereas the theoretical foundations of these…

量子物理 · 物理学 2023-07-07 Alberto Baiardi , Matthias Christandl , Markus Reiher

Rectifying thermal white noise into directed motion is generally believed to require the consumption of energy or information, as exemplified by Maxwell's demon-type feedback controllers. Here we demonstrate a molecular rectification…

统计力学 · 物理学 2026-03-03 Jiantang Jiang

Topological quantum computing has recently proven itself to be a powerful computational model when constructing viable architectures for large scale computation. The topological model is constructed from the foundation of a error correction…

量子物理 · 物理学 2013-06-24 Simon J. Devitt , Kae Nemoto

Many living and physical systems such as cell aggregates, tissues or bacterial colonies behave as unconventional systems of particles that are strongly constrained by volume exclusion and shape interactions. Understanding how these…

定量方法 · 定量生物学 2026-05-20 Antoine Diez , Jean Feydy

Recent experimental research with marine algae points towards quantum entanglement at ambient temperature, with correlations between essential biological units separated by distances as long as 20 Angstr\"oms. The associated decoherence…

量子物理 · 物理学 2015-05-20 Nick E. Mavromatos

The study of many-body quantum dynamics in strongly-correlated systems is extremely challenging. To date few numerical methods exist which are capable of simulating the non-equilibrium dynamics of two-dimensional quantum systems, in part…

量子物理 · 物理学 2024-09-17 S. J. Thomson , J. Eisert

In a previous paper we have introduced a phenomenological model of cell metabolism and of the cell cycle to simulate the behavior of large tumor cell populations (Chignola R and Milotti E, Phys. Biol. 2 (2005) 8-22). Here we describe a…

生物物理 · 物理学 2009-11-13 Roberto Chignola , Alessio Del Fabbro , Chiara Dalla Pellegrina , Edoardo Milotti

The variational principle serves as a fundamental framework for describing equilibrium states of physical systems via the minimization or extremization of an energy-like functional. While quantum algorithms have demonstrated promising…

量子物理 · 物理学 2025-08-26 Katsuhiro Endo , Kazuaki Z. Takahashi