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RNA function is intimately related to its structural dynamics. Molecular dynamics simulations are useful for exploring biomolecular flexibility but are severely limited by the accessible timescale. Enhanced sampling methods allow this…

生物大分子 · 定量生物学 2018-02-06 Vojtěch Mlýnský , Giovanni Bussi

Heterogeneous multiscale methods (HMM) combine molecular accuracy of particle-based simulations with the computational efficiency of continuum descriptions to model flow in soft matter liquids. In these schemes, molecular simulations…

A series of simulations aimed at elucidating the self-assembly dynamics of spherical virus capsids is described. This little-understood phenomenon is a fascinating example of the complex processes that occur in the simplest of organisms.…

软凝聚态物质 · 物理学 2015-05-19 D. C. Rapaport

The aim of this paper is to propose a new numerical model to simulate 2D vesicles interacting with a newtonian fluid. The inextensible membrane is modeled by a chain of circular rigid particles which are maintained in cohesion by using two…

数学物理 · 物理学 2012-02-15 Mourad Ismail , Aline Lefebvre-Lepot

Particle-in-cell methods couple mesh-based methods for the solution of continuum mechanics problems, with the ability to advect and evolve particles. They have a long history and many applications in scientific computing. However, they have…

数值分析 · 数学 2019-09-12 R. Gassmoeller , E. Heien , E. G. Puckett , W. Bangerth

Much of our mechanistic understanding of the functions of biological macromolecules is based on static structural experiments, which can be modelled either as single structures or conformational ensembles. While these provide us with…

生物大分子 · 定量生物学 2025-10-02 Daria Gusew , Carl G. Henning Hansen , Kresten Lindorff-Larsen

Real-life control tasks involve matters of various substances---rigid or soft bodies, liquid, gas---each with distinct physical behaviors. This poses challenges to traditional rigid-body physics engines. Particle-based simulators have been…

机器学习 · 计算机科学 2019-04-19 Yunzhu Li , Jiajun Wu , Russ Tedrake , Joshua B. Tenenbaum , Antonio Torralba

The high-performance computing (HPC) community has recently seen a substantial diversification of hardware platforms and their associated programming models. From traditional multicore processors to highly specialized accelerators, vendors…

等离子体物理 · 物理学 2024-11-11 Josef Ruzicka , Christian Asch , Esteban Meneses , Markus Rampp , Erwin Laure

Particle acceleration in collisionless plasma systems is a central question in astroplasma and astroparticle physics. The structure of the acceleration regions, electron-ion energy equilibration, preacceleration of particles at shocks to…

高能天体物理现象 · 物理学 2020-02-19 Martin Pohl , Masahiro Hoshino , Jacek Niemiec

GROMACS is a widely used package for biomolecular simulation, and over the last two decades it has evolved from small-scale efficiency to advanced heterogeneous acceleration and multi-level parallelism targeting some of the largest…

计算工程、金融与科学 · 计算机科学 2015-06-03 Páll Szilárd , Mark James Abraham , Carsten Kutzner , Berk Hess , Erik Lindahl

The success of high energy physics programs relies heavily on accurate detector simulations and beam interaction modeling. The increasingly complex detector geometries and beam dynamics require sophisticated techniques in order to meet the…

A large number of powerful, high-quality, and open-source simulation packages exist to efficiently perform molecular dynamics simulations, and their prevalence has greatly accelerated discoveries across a wide range of scientific domains.…

软凝聚态物质 · 物理学 2024-05-01 Toler H. Webb , Daniel M. Sussman

Soft slender structures are ubiquitous in natural and artificial systems and can be observed at scales that range from the nanometric to the kilometric, from polymers to space tethers. We present a practical numerical approach to simulate…

流体动力学 · 物理学 2017-08-18 Mattia Gazzola , Levi H. Dudte , Andrew G. McCormick , L. Mahadevan

Although software and firmware co-simulation is gaining popularity, it is still not widely used in the FPGA designs. This work presents easy and structured approach for software and firmware co-simulation for bus centric designs. The…

其他计算机科学 · 计算机科学 2021-10-22 Michał Kruszewski

Computer simulations of coarse-grained molecular models for amphiphilic systems can provide insight into the the structure of amphiphiles at interfaces. They can help to identify the factors that determine the phase behavior, and they can…

软凝聚态物质 · 物理学 2007-05-23 Friederike Schmid , Dominik Düchs , Olaf Lenz , Claire Loison

Accelerated algorithms for simulating the morphological evolution of strained heteroeptiaxy based on a ball and spring lattice model in three dimensions are explained. We derive exact Green's function formalisms for boundary values in the…

统计力学 · 物理学 2008-02-29 Chi-Hang Lam , M. T. Lung , Leonard M. Sander

Particle accelerators are among the largest, most complex devices. To meet the challenges of increasing energy, intensity, accuracy, compactness, complexity and efficiency, increasingly sophisticated computational tools are required for…

加速器物理 · 物理学 2023-01-13 Axel Huebl , Remi Lehe , Chad E. Mitchell , Ji Qiang , Robert D. Ryne , Ryan T. Sandberg , Jean-Luc Vay

Rigid body dynamics simulators are important tools for the design, analysis and optimization of mechanical systems in a variety of technical and scientific applications. This study examines four different simulation environments (Adams,…

机器人学 · 计算机科学 2025-12-23 Longxiang Shao , Ulrich Dahmen , Juergen Rossmann

PyMembrane is a software package for simulating liquid and elastic membranes using a discretisation of the continuum description based on unstructured triangulated two-dimensional meshes embedded in three-dimensional space. The package is…

软凝聚态物质 · 物理学 2023-08-25 D. A. Matoz-Fernandez , Siyu Li , Monica Olvera de la Cruz , Rastko Sknepnek

The edge computing paradigm has emerged to handle cloud computing issues such as scalability, security and low response time among others. This new computing trend heavily relies on ubiquitous embedded systems on the edge. Performance and…

分布式、并行与集群计算 · 计算机科学 2019-01-28 Mohammad Hosseinabady , Mohd Amiruddin Bin Zainol , Jose Nunez-Yanez