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Heterogeneities in the cell membrane due to coexisting lipid phases have been conjectured to play a major functional role in cell signaling and membrane trafficking. Thereby the material properties of multiphase systems, such as the line…

软凝聚态物质 · 物理学 2013-04-17 Stefan Semrau , Timon Idema , Laurent Holtzer , Thomas Schmidt , Cornelis Storm

Blebs are balloon-shaped membrane protrusions that form during many physiological processes. Using computer simulation of a particle-based model for self-assembled lipid bilayers coupled to an elastic meshwork, we investigated the phase…

We describe a novel coarse-grained simulation method for modelling the dynamics of globular macromolecules, such as proteins. The macromolecule is treated as a continuum that is subject to thermal fluctuations. The model includes a…

计算物理 · 物理学 2015-06-11 Robin Oliver , Daniel J. Read , Oliver G. Harlen , Sarah A. Harris

We present a continuum model trained on molecular dynamics (MD) simulations for cellular membranes composed of an arbitrary number of lipid types. The model is constructed within the formalism of dynamic density functional theory and can be…

Kinetics of dislocations is studied by means of computer simulation during intensive plastic deformation. The dynamical effect in the form of soliton-like wave of sharply disrupted interparticle bonds is observed. Along with it, micropores…

材料科学 · 物理学 2007-05-23 L. S. Metlov

Biomembranes, which are mainly composed of neutral and charged lipids, exhibit a large variety of functional structures and dynamics. Here, we report a coarse-grained molecular dynamics (MD) simulation of the phase separation and…

软凝聚态物质 · 物理学 2016-11-07 Hiroaki Ito , Yuji Higuchi , Naofumi Shimokawa

Conformations of a single-component bottle-brush polymer with a fully flexible backbone under poor solvent conditions are studied by molecular-dynamics simulations, using a coarse-grained bead-spring model with side chains of up to N=40…

软凝聚态物质 · 物理学 2013-06-25 Nikolaos G. Fytas , Panagiotis E. Theodorakis

Animal cells are both encapsulated and subdivided by lipid bilayer membranes. Beyond just acting as boundaries, these membranes' shapes influence the function of cells and their compartments. Physically, membranes are two-dimensional fluids…

软凝聚态物质 · 物理学 2023-03-23 George Dadunashvili , Timon Idema

The static and dynamical properties of heavy water have been studied at ambient conditions with extensive Car-Parrinello molecular-dynamics simulations in the canonical ensemble, with temperatures ranging between 325 K and 400 K.…

软凝聚态物质 · 物理学 2007-05-23 P. H-L. Sit , Nicola Marzari

Molecular process of crystallization from an oriented amorphous state was reproduced by molecular dynamics simulation for a realistic polyethylene model. Initial oriented amorphous state was obtained by uniaxial drawing an isotropic glassy…

软凝聚态物质 · 物理学 2009-11-07 Akira Koyama , Takashi Yamamoto , Koji Fukao , Yoshihisa Miyamoto

Solvent-free coarse grained models represent one of the most promising approaches for molecular simulations of mesoscopically large membranes. In these models, the size of the simulated membrane is limited by the slow relaxation time of…

软凝聚态物质 · 物理学 2009-11-13 Oded Farago

We use a coarse-grained molecular model to study the self-assembly process of complexes of cationic and neutral lipids with DNA molecules ("lipoplexes") - a promising nonviral carrier of DNA for gene therapy. We identify the resulting…

软凝聚态物质 · 物理学 2011-05-31 Oded Farago , Niels Grønbech-Jensen

Molecular dynamics simulation is used to study the time-scales involved in the homogeneous melting of a superheated crystal. The interaction model used is an embedded-atom model for Fe developed in previous work, and the melting process is…

统计力学 · 物理学 2015-05-27 D. Alfè , C. Cazorla , M. J. Gillan

Understanding interactions between membranes requires measurements on well-controlled systems close to natural conditions, in which fluctuations play an important role. We have determined, by grazing incidence X-ray scattering, the…

In this work we study the diffusion mechanisms in lithium disilicate melt using molecular dynamics simulation, which has an edge over other simulation methods because it can track down actual atomic rearrangements in materials once a…

材料科学 · 物理学 2014-05-30 Luis G. V. Gonçalves , José P. Rino

The purpose of this paper is to study the shapes and stabilities of bio-membranes within the framework of exterior differential forms. After a brief review of the current status in theoretical and experimental studies on the shapes of…

软凝聚态物质 · 物理学 2007-05-23 Z. C. Tu , Z. C. Ou-Yang

The statistical physics and dynamics of double supported bilayers are studied theoretically. The main goal in designing double supported lipid bilayers is to obtain model systems of biomembranes: the upper bilayer is meant to be almost…

软凝聚态物质 · 物理学 2015-03-13 Manoel Manghi , Nicolas Destainville

We report a molecular dynamics simulation study of a model gel whose interaction potential is obtained by modifying the three body Stillinger-Weber model potential for silicon. The modification reduces the average coordination number, and…

软凝聚态物质 · 物理学 2015-05-14 Shibu Saw , Niels L. Ellegaard , Walter Kob , Srikanth Sastry

The liquid crystalline model biomembrane system consisting of a stack of interacting membranes is studied by the newly developed Fourier Monte Carlo simulation technique. In comparison to perturbation theory, substantial quantitative…

生物物理 · 物理学 2007-05-23 Nikolai Gouliaev , John F. Nagle

We study the thermodynamics of binary mixtures with the volume fraction of the minority component less than the amount required to form a flat interface and show that the surface tension dominated equilibrium phase of the mixture forms a…

软凝聚态物质 · 物理学 2023-03-07 Subhadip Biswas , Biswaroop Mukherjee , Buddhapriya Chakrabarti