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Purpose: This study aimed to enhance protein sequence classification using natural language processing (NLP) techniques while addressing the impact of sequence similarity on model performance. We compared various machine learning and deep…

定量方法 · 定量生物学 2025-05-26 Huma Perveen , Julie Weeds

Amino acid sequence portrays most intrinsic form of a protein and expresses primary structure of protein. The order of amino acids in a sequence enables a protein to acquire a particular stable conformation that is responsible for the…

机器学习 · 计算机科学 2022-08-29 Ashish Ranjan , Md Shah Fahad , David Fernandez-Baca , Akshay Deepak , Sudhakar Tripathi

Tree-based methods are powerful nonparametric techniques in statistics and machine learning. However, their effectiveness, particularly in finite-sample settings, is not fully understood. Recent applications have revealed their surprising…

统计理论 · 数学 2024-10-04 Hengrui Luo , Meng Li

Classification and Regression Trees (CARTs) are off-the-shelf techniques in modern Statistics and Machine Learning. CARTs are traditionally built by means of a greedy procedure, sequentially deciding the splitting predictor variable(s) and…

Eliciting preferences from human judgements is inherently imprecise, yet most decision analysis methods force a single priority vector from pairwise comparisons, discarding the information embedded in inconsistencies. We instead leverage…

综合经济学 · 经济学 2026-02-27 Salvatore Greco , Sajid Siraj , Michele Lundy

Motivation: Many inference tools use the Perfect Phylogeny Model (PPM) to learn trees from noisy variant allele frequency (VAF) data. Learning in this setting is hard, and existing tools use approximate or heuristic algorithms. An…

定量方法 · 定量生物学 2019-08-26 Surjyendu Ray , Bei Jia , Sam Safavi , Tim van Opijnen , Ralph Isberg , Jason Rosch , José Bento

Testing and characterizing the difference between two data samples is of fundamental interest in statistics. Existing methods such as Kolmogorov-Smirnov and Cramer-von-Mises tests do not scale well as the dimensionality increases and…

统计方法学 · 统计学 2011-03-23 Li Ma , Wing H. Wong

Research in bioinformatics is a complex phenomenon as it overlaps two knowledge domains, namely, biological and computer sciences. This paper has tried to introduce an efficient data mining approach for classifying proteins into some useful…

计算工程、金融与科学 · 计算机科学 2011-11-11 Muhammad Mahbubur Rahman , Arif Ul Alam , Abdullah-Al-Mamun , Tamnun E Mursalin

Several studies have shown that combining machine learning models in an appropriate way will introduce improvements in the individual predictions made by the base models. The key to make well-performing ensemble model is in the diversity of…

机器学习 · 计算机科学 2021-03-01 Mohsen Shahhosseini , Guiping Hu

Most real-world classification problems deal with imbalanced datasets, posing a challenge for Artificial Intelligence (AI), i.e., machine learning algorithms, because the minority class, which is of extreme interest, often proves difficult…

The typical process for classifying and submitting a newly sequenced virus to the NCBI database involves two steps. First, a BLAST search is performed to determine likely family candidates. That is followed by checking the candidate…

基因组学 · 定量生物学 2016-03-22 Troy Hernandez , Jie Yang

We study the problem of formally verifying individual fairness of decision tree ensembles, as well as training tree models which maximize both accuracy and individual fairness. In our approach, fairness verification and fairness-aware…

机器学习 · 计算机科学 2021-01-05 Francesco Ranzato , Caterina Urban , Marco Zanella

While modern biotechnologies allow synthesizing new proteins and function measurements at scale, efficiently exploring a protein sequence space and engineering it remains a daunting task due to the vast sequence space of any given protein.…

生物大分子 · 定量生物学 2024-01-15 Jiahao Qiu , Hui Yuan , Jinghong Zhang , Wentao Chen , Huazheng Wang , Mengdi Wang

We resolve a long-standing open question, about the existence of a constant-factor approximation algorithm for the average-case \textsc{Decision Tree} problem with uniform probability distribution over the hypotheses. We answer the question…

数据结构与算法 · 计算机科学 2026-04-29 Michał Szyfelbein

The performance of coverage-based fault localization greatly depends on the quality of test cases being executed. These test cases execute some lines of the given program and determine whether the underlying tests are passed or failed. In…

软件工程 · 计算机科学 2020-06-17 Shuvalaxmi Dass , Xiaozhen Xue , Akbar Siami Namin

This paper presents a brand new nonparametric density estimation strategy named the best-scored random forest density estimation whose effectiveness is supported by both solid theoretical analysis and significant experimental performance.…

机器学习 · 统计学 2019-05-10 Hanyuan Hang , Hongwei Wen

Label ranking aims to learn a mapping from instances to rankings over a finite number of predefined labels. Random forest is a powerful and one of the most successful general-purpose machine learning algorithms of modern times. In this…

机器学习 · 计算机科学 2018-06-19 Yangming Zhou , Guoping Qiu

Tree-boosting is a widely used machine learning technique for tabular data. However, its out-of-sample accuracy is critically dependent on multiple hyperparameters. In this article, we empirically compare several popular methods for…

机器学习 · 计算机科学 2026-05-29 Floris Jan Koster , Fabio Sigrist

In the field of decision trees, most previous studies have difficulty ensuring the statistical optimality of a prediction of new data and suffer from overfitting because trees are usually used only to represent prediction functions to be…

机器学习 · 计算机科学 2023-06-13 Yuta Nakahara , Shota Saito , Naoki Ichijo , Koki Kazama , Toshiyasu Matsushima

Monitoring random profiles over time is used to assess whether the system of interest, generating the profiles, is operating under desired conditions at any time-point. In practice, accurate detection of a change-point within a sequence of…

统计方法学 · 统计学 2024-07-16 Daniel A. Timme , Andrés F. Barrientos , Eric Chicken , Debajyoti Sinha