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This article explains, and discusses the merits of, three approaches for analyzing the certainty with which statistical results can be extrapolated beyond the data gathered. Sometimes it may be possible to use more than one of these…

统计方法学 · 统计学 2016-10-03 Michael Wood

Statistical dependence between hypotheses poses a significant challenge to the stability of large scale multiple hypotheses testing. Ignoring it often results in an unacceptably large spread in the false positive proportion even though the…

统计方法学 · 统计学 2018-10-15 Sairam Rayaprolu , Zhiyi Chi

For estimating the proportion of false null hypotheses in multiple testing, a family of estimators by Storey (2002) is widely used in the applied and statistical literature, with many methods suggested for selecting the parameter $\lambda$.…

统计方法学 · 统计学 2024-05-07 Anica Kostic , Piotr Fryzlewicz

A new formulation for the proportion of true null hypotheses $(\pi_0)$, based on the sum of all $p$-values and the average of expected $p$-value under the false null hypotheses has been proposed in the current work. This formulation of the…

统计理论 · 数学 2020-04-07 Aniket Biswas

The probability of false discovery proportion (FDP) exceeding $\gamma\in[0,1)$, defined as $\gamma$-FDP, has received much attention as a measure of false discoveries in multiple testing. Although this measure has received acceptance due to…

统计理论 · 数学 2014-06-03 Wenge Guo , Li He , Sanat K. Sarkar

A popular framework for false discovery control is the random effects model in which the null hypotheses are assumed to be independent. This paper generalizes the random effects model to a conditional dependence model which allows…

统计理论 · 数学 2008-12-18 Wei Biao Wu

The statistics and machine learning communities have recently seen a growing interest in classification-based approaches to two-sample testing. The outcome of a classification-based two-sample test remains a rejection decision, which is not…

统计理论 · 数学 2022-11-15 Loris Michel , Jeffrey Näf , Nicolai Meinshausen

We consider estimating the proportion of random variables for two types of composite null hypotheses: (i) the means or medians of the random variables belonging to a non-empty, bounded interval; (ii) the means or medians of the random…

统计理论 · 数学 2025-03-24 Xiongzhi Chen

Consider the problem of testing multiple null hypotheses. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($FWER$), the probability of even one…

统计理论 · 数学 2007-06-13 Joseph P. Romano , Azeem M. Shaikh

In traditional hypothesis testing one must pre-specify the significance level $\alpha$ to bound the `size' of the test: its probability to falsely reject the hypothesis. Indeed, a data-dependent selection of $\alpha$ would generally distort…

统计理论 · 数学 2025-12-03 Nick W. Koning

Modern statisticians are often presented with hundreds or thousands of hypothesis testing problems to evaluate at the same time, generated from new scientific technologies such as microarrays, medical and satellite imaging devices, or flow…

应用统计 · 统计学 2008-12-18 Bradley Efron

A method is described, which computes from an observed sample of events upper limits for production rates of particles, or, in case of appearance of a signal, the probability for an upwards fluctuation of the background. For any candidate,…

高能物理 - 实验 · 物理学 2010-10-27 P. Bock

Score-based statistical models play an important role in modern machine learning, statistics, and signal processing. For hypothesis testing, a score-based hypothesis test is proposed in \cite{wu2022score}. We analyze the performance of this…

信号处理 · 电气工程与系统科学 2024-02-06 Enmao Diao , Taposh Banerjee , Vahid Tarokh

Is it possible for a large sequence of measurements or observations, which support a hypothesis, to counterintuitively decrease our confidence? Can unanimous support be too good to be true? The assumption of independence is often made in…

In Dark Matter direct detection we are facing the situation of some experiments reporting positive signals which are in conflict with limits from other experiments. Such conclusions are subject to large uncertainties introduced by the…

宇宙学与河外天体物理 · 物理学 2015-06-23 Nassim Bozorgnia , Thomas Schwetz

An important issue raised by Efron in the context of large-scale multiple comparisons is that in many applications the usual assumption that the null distribution is known is incorrect, and seemingly negligible differences in the null may…

统计理论 · 数学 2007-06-13 Jiashun Jin , T. Tony Cai

Large-scale multiple testing is a fundamental problem in high dimensional statistical inference. It is increasingly common that various types of auxiliary information, reflecting the structural relationship among the hypotheses, are…

统计方法学 · 统计学 2021-10-07 Hongyuan Cao , Jun Chen , Xianyang Zhang

This paper presents a clustering approach that allows for rigorous statistical error control similar to a statistical test. We develop estimators for both the unknown number of clusters and the clusters themselves. The estimators depend on…

统计理论 · 数学 2017-07-13 Michael Vogt , Matthias Schmid

We discuss a new method for setting limits on small signals in the presence of background noise. The method is based on a combination of a two dimensional confidence region and the large sample approximation to the likelihood ratio test…

高能物理 - 唯象学 · 物理学 2009-10-31 Wolfgang A. Rolke , Angel M. Lopez

We consider statistical hypothesis testing simultaneously over a fairly general, possibly uncountably infinite, set of null hypotheses, under the assumption that a suitable single test (and corresponding $p$-value) is known for each…

统计方法学 · 统计学 2014-02-10 Gilles Blanchard , Sylvain Delattre , Etienne Roquain