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Cancer results from genetic alterations that disturb the normal cooperative behavior of cells. Recent high-throughput genomic studies of cancer cells have shown that the mutational landscape of cancer is complex and that individual cancers…

Recombination is a powerful evolutionary process that shapes the genetic diversity observed in the populations of many species. Reconstructing genealogies in the presence of recombination from sequencing data is a very challenging problem,…

种群与进化 · 定量生物学 2022-06-01 Elizabeth Hayman , Anastasia Ignatieva , Jotun Hein

The Metric Coalescent (MC) is a measure-valued Markov Process generalizing the classical Kingman Coalescent. We show how the MC arises naturally from a discrete agent based model (Compulsive Gambler) of social dynamics and prove an…

概率论 · 数学 2014-06-05 Daniel Lanoue

We establish convergence to the Kingman coalescent for the genealogy of a geographically - or otherwise - structured version of the Wright-Fisher population model with fast migration. The new feature is that migration probabilities may…

概率论 · 数学 2010-06-25 Serik Sagitov , Peter Jagers , Vladimir Vatutin

The inference of the evolutionary history of a collection of organisms is a problem of fundamental importance in evolutionary biology. The abundance of DNA sequence data arising from genome sequencing projects has led to significant…

种群与进化 · 定量生物学 2015-07-07 Julia Chifman , Laura Kubatko

We consider the enumeration of plane trees (rooted ordered trees) whose vertices are colored according to a specific coloring rule that prescribes which possible pairs of colors can occur as the colors of a parent vertex and its child. This…

组合数学 · 数学 2026-02-19 Stoyan Dimitrov , Nathan Fox , Kimberly Hadaway , Ashley Tharp , Stephan Wagner

A statistical learning/inference framework for color demosaicing is presented. We start with simplistic assumptions about color constancy, and recast color demosaicing as a blind linear inverse problem: color parameterizes the unknown…

计算机视觉与模式识别 · 计算机科学 2010-02-12 J. H. Oaknin

Kingman's coalescent is a widely used process to model sample genealogies in population genetics. Recently there have been studies on the inference of quantities related to the genealogy of additional individuals given a known sample. This…

概率论 · 数学 2024-02-29 Linglong Yuan

In this paper, we propose a high-speed greedy sequential algorithm for the vertex coloring problem (VCP), based on the Wave Function Collapse algorithm, called Wave Function Collapse Coloring (WFC-C). An iteration of this algorithm goes…

数据结构与算法 · 计算机科学 2021-08-24 Anh Mac , David Perkins

The multi-species coalescent provides an elegant theoretical framework for estimating species trees and species demographics from genetic markers. Practical applications of the multi-species coalescent model are, however, limited by the…

种群与进化 · 定量生物学 2011-11-09 David Bryant , Remco Bouckaert , Joseph Felsenstein , Noah Rosenberg , Arindam RoyChoudhury

We propose Generative Probabilistic Image Colorization, a diffusion-based generative process that trains a sequence of probabilistic models to reverse each step of noise corruption. Given a line-drawing image as input, our method suggests…

计算机视觉与模式识别 · 计算机科学 2021-09-30 Chie Furusawa , Shinya Kitaoka , Michael Li , Yuri Odagiri

Consider a population evolving from year to year through three seasons: spring, summer and winter. Every spring starts with $N$ dormant individuals waking up independently of each other according to a given distribution. Once an individual…

The multispecies coalescent process models the genealogical relationships of genes sampled from several species, enabling useful predictions about phenomena such as the discordance between the gene tree and the species phylogeny due to…

种群与进化 · 定量生物学 2020-12-11 Jakub Truszkowski , Celine Scornavacca , Fabio Pardi

Consider a random real tree whose leaf set, or boundary, is endowed with a finite mass measure. Each element of the tree is further given a type, or allele, inherited from the most recent atom of a random point measure…

概率论 · 数学 2018-09-26 Jean-Jil Duchamps , Amaury Lambert

When an advantageous mutation occurs in a population, the favorable allele may spread to the entire population in a short time, an event known as a selective sweep. As a result, when we sample $n$ individuals from a population and trace…

概率论 · 数学 2007-05-23 Rick Durrett , Jason Schweinsberg

The transition distribution of a sample taken from a Wright-Fisher diffusion with general small mutation rates is found using a coalescent approach. The approximation is equivalent to having at most one mutation in the coalescent tree of…

种群与进化 · 定量生物学 2019-09-12 Conrad J. Burden , Robert C. Griffiths

Forward-time models of diversification (i.e., speciation and extinction) produce phylogenetic trees that grow "vertically" as time goes by. Pruning the extinct lineages out of such trees leads to natural models for reconstructed trees…

种群与进化 · 定量生物学 2013-08-07 Amaury Lambert , Tanja Stadler

The nested Kingman coalescent describes the dynamics of particles (called genes) contained in larger components (called species), where pairs of species coalesce at constant rate and pairs of genes coalesce at constant rate provided they…

概率论 · 数学 2018-07-25 Amaury Lambert , Emmanuel Schertzer

We consider the Wright-Fisher model for a population of $N$ individuals, each identified with a sequence of a finite number of sites, and single-crossover recombination between them. We trace back the ancestry of single individuals from the…

概率论 · 数学 2014-04-24 Ellen Baake , Ute von Wangenheim

Coalescence processes have received a lot of attention in the context of conditional branching processes with fixed population size and non-overlapping generations. Here we focus on similar problems in the context of the standard…

概率论 · 数学 2017-09-25 Nicolas Grosjean , Thierry Huillet