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We show the existence of a critical endpoint in the phase diagram of unzipping of an adsorbed double-stranded (ds) polymer like DNA. The competition of base pairing, adsorption and stretching by an external force leads to the critical end…

软凝聚态物质 · 物理学 2008-09-16 Rajeev Kapri , Somendra M. Bhattacharjee

We study the melting of a double stranded DNA in the presence of stretching forces, via 3D Monte-Carlo simulations, exactly solvable models and heuristic arguments. The resulting force-temperature phase diagram is dramatically different for…

软凝聚态物质 · 物理学 2008-07-22 D. Marenduzzo , A. Maritan , E. Orlandini , F. Seno , A. Trovato

Macromolecular crowding plays a principal role in a wide range of biological processes including gene expression, chromosomal compaction, and viral infection. However, the impact that crowding has on the dynamics of nucleic acids remains a…

Single molecule experiments on single- and double stranded DNA have sparked a renewed interest in the force-extension of polymers. The extensible Freely Jointed Chain (FJC) model is frequently invoked to explain the observed behavior of…

生物物理 · 物理学 2009-11-07 Cornelis Storm , Philip Nelson

Heterogeneous distribution of passive and active domains in the chromosome plays a crucial role for its dynamic organization within the cell nucleus. Motivated by that here we investigate the steady-state conformation and dynamics of a…

软凝聚态物质 · 物理学 2024-09-27 Suman Majumder , Subhajit Paul

We report a numerical study of the diffusiophoresis of short polymers using non-equilibrium molecular dynamics simulations. More precisely, we consider polymer chains in a fluid containing a solute which has a concentration gradient, and…

软凝聚态物质 · 物理学 2020-05-20 Simón Ramírez-Hinestrosa , Hiroaki Yoshida , Lydéric Bocquet , Daan Frenkel

When mixed together, DNA and polyaminoamide (PAMAM) dendrimers form fibers that condense into a compact structure. We use optical tweezers to pull condensed fibers and investigate the decondensation transition by measuring force-extension…

软凝聚态物质 · 物理学 2009-11-11 F. Ritort , S. Mihardja , S. B. Smith , C. Bustamante

Entangled ring polymers, along with blends of ring and linear polymers, continue to be a topic of great interest and debate due to the conflicting experimental results in the literature as well as the difficulty of producing entangled…

软凝聚态物质 · 物理学 2020-05-27 K. R. Peddireddy , M. Lee , C. M. Schroeder , R. M. Robertson-Anderson

Natural supports of information are given by random copolymers such as DNA or RNA where information is coded in the sequence of covalent bonds. At the molecular scale, the stochastic growth of a single copolymer with or without a template…

生物大分子 · 定量生物学 2016-04-12 Pierre Gaspard

Some recent results on the rotational dynamics of polymers are reviewed and extended. We focus here on the relaxation of a polymer, either flexible or semiflexible, initially wrapped around a rigid rod. We also study the steady polymer…

统计力学 · 物理学 2015-06-22 Jean-Charles Walter , Michiel Laleman , Marco Baiesi , Enrico Carlon

We investigate the conformational and dynamical properties of a partially active Rouse chain, where activity is localized within a specific segment, positioned at various locations along the chain and spanning any given length. Through…

软凝聚态物质 · 物理学 2024-12-06 Koushik Goswami , Norman Hsia , Cheng-Hung Chang , Hong-Yan Shih

The two strands of a DNA molecule with a repetitive sequence can pair into many different basepairing patterns. For perfectly periodic sequences, early bulk experiments of Poerschke indicate the existence of a sliding process, permitting…

生物大分子 · 定量生物学 2007-05-23 Richard A. Neher , Ulrich Gerland

We study single-chain motion in semidilute solutions of polymers of length N = 1000 with excluded-volume and hydrodynamic interactions by a novel algorithm. The crossover length of the transition from Zimm (short lengths and times) to Rouse…

软凝聚态物质 · 物理学 2009-10-31 Patrick Ahlrichs , Ralf Everaers , Burkhard Duenweg

Polymer translocation through a nanopore in a membrane investigated theoretically. Recent experiments on voltage-driven DNA and RNA translocations through a nanopore indicate that the size and geometry of the pore are important factors in…

统计力学 · 物理学 2009-11-07 Elena Slonkina , Anatoly B. Kolomeisky

We characterize the equilibrium thermodynamics of a thick polymer confined in a spherical region of space. This is used to gain insight into the DNA packaging process. The experimental reference system for the present study is the recent…

统计力学 · 物理学 2007-05-23 Davide Marenduzzo , Cristian Micheletti

We consider two complementary polymer strands of length $L$ attached by a common end monomer. The two strands bind through complementary monomers and at low temperatures form a double stranded conformation (zipping), while at high…

统计力学 · 物理学 2015-03-19 Jean-Charles Walter , Alessandro Ferrantini , Enrico Carlon , Carlo Vanderzande

Single-molecule experiments in which force is applied to DNA or RNA molecules have enabled important discoveries of nucleic acid properties and nucleic acid-enzyme interactions. These experiments rely on a model of the polymer…

生物物理 · 物理学 2011-11-09 Jinyu Li , Philip C. Nelson , M. D. Betterton

The pair interaction between two stiff parallel linear DNA molecules depends not only on the distance between their axes but on their azimuthal orientation. The positional and orientational order in columnar B-DNA assemblies in solution is…

软凝聚态物质 · 物理学 2009-11-07 H. M. Harreis , A. A. Kornyshev , C. N. Likos , H. Loewen , G. Sutmann

The nanoscale fluctuation dynamics of semi dilute high molecular weight polymer solutions of Polyethylenoxide (PEO) in D2O under non-equilibrium flow conditions were studied by the neutron spin-echo technique. The sample cell was in…

流体动力学 · 物理学 2011-06-16 Maikel C. Rheinstadter , Rainer Sattler , Wolfgang Haeussler , Christian Wagner

Genetic information is stored in a linear sequence of base-pairs; however, thermal fluctuations and complex DNA conformations such as folds and loops make it challenging to order genomic material for in vitro analysis. In this work, we…