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We show that the correlated stochastic fluctuation of the friction coefficient can give rise to long-range directional motion of a particle undergoing Brownian random walk in a constant periodic energy potential landscape. The occurrence of…

软凝聚态物质 · 物理学 2009-11-07 Lorenzo Marrucci , Domenico Paparo , Markus Kreuzer

Recent experiments demonstrate that molecular motors from the Myosin II family serve as cross-links inducing active tension in the cytoskeletal network. Here we revise the Brownian ratchet model, previously studied in the context of active…

生物物理 · 物理学 2017-09-29 Pieter Baerts , Christian Maes , Jiří Pešek , Herman Ramon

A ratchet model for coupled Brownian motors, inspired by the motion of individual two-headed molecular motors on cytoskeletal filaments, is proposed. Such motors are modeled as two elastically coupled Brownian particles, each of which moves…

软凝聚态物质 · 物理学 2009-11-07 Debasis Dan , A. M. Jayannavar , Gautam I. Menon

Mechanochemical coupling was studied for two different types of myosin motors in cells: myosin V, which carries cargo over long distances by as a single molecule; and myosin II, which generates a contracting force in cooperation with other…

亚细胞过程 · 定量生物学 2009-11-13 Masatoshi Nishikawa , Hiroaki Takagi , Atsuko H. Iwane , Toshio Yanagida

The cytoskeletal component actomyosin is a canonical example of active matter since the powerstroke cycle locally converts chemical energy in the form of adenoside triphosphate (ATP) into mechanical work for remodelling. Observing myosin II…

We give an overview over recent studies on the model of Active Brownian Motion (ABM) coupled to reservoirs providing free energy which may be converted into kinetic energy of motion. First, we present an introduction to a general concept of…

数据分析、统计与概率 · 物理学 2009-11-13 Alessandro Fiasconaro , Werner Ebeling , Ewa Gudowska-Nowak

The muscle contraction, operation of ATP synthase, maintaining the shape of a cell are believed to be secured by motor proteins, which can be modelled using the Brownian ratchet mechanism. We consider the randomly flashing ratchet model of…

经典分析与常微分方程 · 数学 2013-05-09 Dmitry Vorotnikov

Contractile forces are essential for many developmental processes involving cell shape change and tissue deformation. Recent experiments on reconstituted actomyosin networks, the major component of the contractile machinery, have shown that…

生物物理 · 物理学 2012-05-31 Shenshen Wang , Peter G. Wolynes

The origin of biological motion can be traced back to the function of molecular motor proteins. Cytoplasmic dynein and kinesin transport organelles within our cells moving along a polymeric filament, the microtubule. The motion of the…

统计力学 · 物理学 2015-06-25 Imre Derenyi , Tamas Vicsek

We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by…

亚细胞过程 · 定量生物学 2007-05-23 A. Buonocore , L. Caputo , Y. Ishii , E. Pirozzi , T. Yanagida , L. M. Ricciardi

Force fluctuations exhibited in focal adhesions (FAs) that connect a cell to its extracellular environment, point to the complex role of the underlying machinery that controls cell migration. To elucidate the explicit role of myosin motors…

生物物理 · 物理学 2022-03-29 Debsuvra Ghosh , Subhadip Ghosh , Abhishek Chaudhuri

Molecular motors convert chemical energy derived from the hydrolysis of ATP into mechanical energy. A well-studied model of a molecular motor is the flashing ratchet model. We show that this model exhibits a fluctuation relation known as…

统计力学 · 物理学 2015-05-13 D. Lacoste , K. Mallick

We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by…

生物大分子 · 定量生物学 2007-05-23 A. Buonocore , L. Caputo , Y. Ishii , E. Pirozzi , T. Yanagida , L. M. Ricciardi

In recent literature there has been a lot of interest in the phenomena of noise induced transport in the absence of an average bias occurring in spatially periodic systems far from equilibrium. One of the main motivations in this area is to…

生物物理 · 物理学 2007-05-23 Raishma Krishnan , A. M. Jayannavar

Brownian motors, or ratchets, are devices which "rectify" Brownian motion, i.e. they can generate a current of particles out of unbiased fluctuations. The ratchet effect is a very general phenomenon which applies to a wide range of physical…

统计力学 · 物理学 2011-12-06 F. Renzoni

Brownian rotors play an important role in biological systems and in future nano-technological applications. However the mechanisms determining their dynamics, efficiency and performance remain to be characterized. Here the F0 portion of the…

生物物理 · 物理学 2009-11-13 Wolfgang R. Bauer , Walter Nadler

The growth of actin filament networks is a fundamental biological process that drives a variety of cellular and intracellular motions. During motility, eukaryotic cells and intracellular pathogens are propelled by actin networks organized…

生物物理 · 物理学 2009-11-13 Joshua W. Shaevitz , Daniel A. Fletcher

On the basis of the transport features and experimental phenomena observed in studies of molecular motors, we proposea double-temperature ratchet model of coupled motors to reveal the dynamical mechanism of cooperative transport of motors…

经典物理 · 物理学 2017-02-24 Chen-pu Li , Hong-bin Chen , Zhi-gang Zheng

We investigate the model of "reversible ratchet" with interacting particles, introduced by us earlier [Europhys. Lett. 84, 50009 (2008)]. We further clarify the effect of efficiency enhancement due to interaction and show that it is of…

统计力学 · 物理学 2015-03-19 Frantisek Slanina

The purpose of this work is to present the concept of an autonomous Stirling-like engine powered by anisotropy of thermodynamic fluctuations. Specifically, simultaneous contact of a thermodynamic system with two heat baths along coupled…

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