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Single strand breaks are induced in DNA plasmids, pBR322 and pUC19, in aqueous media by intense ultrashort laser pulses (820 nm wavelength, 45 fs pulse duration, 1 kHz repetition rate) at intensities of 1-12 TW cm$^{-2}$. The intense laser…

生物物理 · 物理学 2010-06-03 J. S. D'Souza , J. A. Dharmdhikari , A. K. Dharmdhikair , B. J. Rao , D. Mathur

The twisting deformation of mechanically stretched DNA molecules is studied by a coarse grained Hamiltonian model incorporating the fundamental interactions that stabilize the double helix and accounting for the radial and angular base pair…

软凝聚态物质 · 物理学 2017-12-15 Marco Zoli

A theory of the unzipping of double-stranded (ds) DNA is presented, and is compared to recent micromanipulation experiments. It is shown that the interactions which stabilize the double helix and the elastic rigidity of single strands (ss)…

统计力学 · 物理学 2009-11-07 S. Cocco , R. Monasson , J. Marko

The maximum entropy principle in Tsallis statistics is reformulated in the mathematical framework of the q-product, which results in the unique non self-referential q-canonical distribution. As one of the applications of the present…

统计力学 · 物理学 2009-11-11 Hiroki Suyari

Since the discovery of the first double neutron star (DNS) system, the number of these exotic binaries has reached fifteen. Here we investigate a channel of DNS formation in binary systems with components above the mass limit of type II…

太阳与恒星天体物理 · 物理学 2023-06-28 Viktória Fröhlich , Zsolt Regály , József Vinkó

Single strand breaks are induced in DNA plasmids, pBR322 and pUC19, in aqueous media exposed to strong fields generated using ultrashort laser pulses (820 nm wavelength, 45 fs pulse duration, 1 kHz repetition rate) at intensities of 1-12 TW…

生物物理 · 物理学 2015-05-27 J. S. D'Souza , J. A. Dharmadhikari , A. K. Dharmadhikari , B. J. Rao , D. Mathur

Complementary strands in DNA double helix show temporary fluctuational openings which are essential to biological functions such as transcription and replication of the genetic information. Such large amplitude fluctuations, known as the…

生物物理 · 物理学 2013-02-12 Marco Zoli

The problem of differentiating the informational content of coding (exons) and non-coding (introns) regions of a DNA sequence is one of the central problems of genomics. The introns are estimated to be nearly 95% of the DNA and since they…

计算工程、金融与科学 · 计算机科学 2010-10-21 Riyazuddin Mohammed

In solution, DNA is a highly charged macromolecule which bears a unit of negative charge on each phosphate of its sugar-phosphate backbone. Although partially compensated by counterions adsorbed at or condensed near it, DNA still produces a…

软凝聚态物质 · 物理学 2024-03-11 Jonathan G. Hedley , Kush Coshic , Aleksei Aksimentiev , Alexei A. Kornyshev

The production of two double strand breaks in spatially separated locations on the DNA molecule can cause the loss of a whole DNA loop, which can be of substantial length depending on the geometrical position of the two damaged sites and…

仪器与探测器 · 物理学 2022-09-07 Gerhard Hilgers , Thomas Braunroth , Hans Rabus

For a model of DNA denaturation, exponents describing the distributions of denaturated loops and unzipped end-segments are determined by exact enumeration and by Monte Carlo simulations in two and three dimensions. The loop distributions…

统计力学 · 物理学 2007-05-23 Marco Baiesi , Enrico Carlon , Attilio Stella

This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The analysis and assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms…

生物物理 · 物理学 2012-01-30 Eugene Surdutovich , David C. Gallagher , Andrey V. Solov'yov

Due to its longevity and enormous information density, DNA is an attractive medium for archival data storage. Thanks to rapid technological advances, DNA storage is becoming practically feasible, as demonstrated by a number of experimental…

信息论 · 计算机科学 2022-11-11 Ilan Shomorony , Reinhard Heckel

Using high-quality gas phase electron scattering calculations and multiple scattering theory, we attempt to gain insights on the radiation damage to DNA induced by secondary low-energy electrons in the condensed phase, and to bridge the…

化学物理 · 物理学 2009-11-13 Laurent Caron , Stefano Tonzani , Chris H. Greene , Leon Sanche

We propose a new method for electrophoretic separation of DNA in which adsorbed polymers are driven over a disordered two-dimensional substrate which contains attractive sites for the polymers. Using simulations of a model for long polymer…

软凝聚态物质 · 物理学 2008-03-31 C. J. Olson Reichhardt , C. Reichhardt

The complexity of the primary structure of human DNA is explored using methods from nonequilibrium statistical mechanics, dynamical systems theory and information theory. The use of chi-square tests shows that DNA cannot be described as a…

基因组学 · 定量生物学 2015-06-17 A. Provata , C. Nicolis , G. Nicolis

We calculate the entropic part of partition function of a bubble embedded in a double stranded DNA (dsDNA) by considering the total weights of possible configurations of a system of two single stranded DNA (ssDNA) of given length which…

软凝聚态物质 · 物理学 2009-09-10 Yashwant Singh

A simple model of DNA based on two interacting polymers has been used to study the unzipping of a double stranded DNA subjected to a periodic force. We propose a dynamical transition, where without changing the physiological condition, it…

生物物理 · 物理学 2015-06-11 Sanjay Kumar , Garima Mishra

We propose a dynamical model for the secondary structure of DNA, which is based on the finite stacking enthalpies used in thermodynamics calculations. In this model, the two strands can separate and the bases are allowed to rotate…

生物物理 · 物理学 2016-08-16 Sahin Buyukdagli , Michaël Sanrey , Marc Joyeux

This paper aims at a comprehensive understanding on the novel elastic property of double-stranded DNA (dsDNA) discovered very recently through single-molecule manipulation techniques. A general elastic model for double-stranded biopolymers…

软凝聚态物质 · 物理学 2009-10-31 Haijun Zhou , Yang Zhang , Zhong-can Ou-Yang