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We train a neural network to predict distributional responses in gene expression following genetic perturbations. This is an essential task in early-stage drug discovery, where such responses can offer insights into gene function and inform…

Imitation learning is an intuitive approach for teaching motion to robotic systems. Although previous studies have proposed various methods to model demonstrated movement primitives, one of the limitations of existing methods is that the…

机器人学 · 计算机科学 2020-09-24 Takayuki Osa , Shuhei Ikemoto

Cellular response to a perturbation is the result of a dynamic system of biological variables linked in a complex network. A major challenge in drug and disease studies is identifying the key factors of a biological network that are…

应用统计 · 统计学 2014-09-02 Lisa M. Pham , Luis Carvalho , Scott Schaus , Eric D. Kolaczyk

Variational Autoencoders (VAEs) are powerful generative models for learning latent representations. Standard VAEs generate dispersed and unstructured latent spaces by utilizing all dimensions, which limits their interpretability, especially…

计算机视觉与模式识别 · 计算机科学 2025-05-21 Farshad Sangari Abiz , Reshad Hosseini , Babak N. Araabi

The variational autoencoder (VAE) is a popular deep latent variable model used to analyse high-dimensional datasets by learning a low-dimensional latent representation of the data. It simultaneously learns a generative model and an…

机器学习 · 计算机科学 2023-11-21 Mine Öğretir , Siddharth Ramchandran , Dimitrios Papatheodorou , Harri Lähdesmäki

As one of the most popular generative models, Variational Autoencoder (VAE) approximates the posterior of latent variables based on amortized variational inference. However, when the decoder network is sufficiently expressive, VAE may lead…

机器学习 · 计算机科学 2021-10-26 Dazhong Shen , Chuan Qin , Chao Wang , Hengshu Zhu , Enhong Chen , Hui Xiong

Learning identifiable representations and models from low-level observations is helpful for an intelligent spacecraft to complete downstream tasks reliably. For temporal observations, to ensure that the data generating process is provably…

机器学习 · 计算机科学 2024-12-05 Congxi Zhang , Yongchun Xie

Recent advances in Deep Learning and probabilistic modeling have led to strong improvements in generative models for images. On the one hand, Generative Adversarial Networks (GANs) have contributed a highly effective adversarial learning…

计算机视觉与模式识别 · 计算机科学 2018-08-14 Yang He , Bernt Schiele , Mario Fritz

Modelling the complexity and diversity of human activity scheduling behaviour is inherently challenging. We demonstrate a deep conditional-generative machine learning approach for the modelling of realistic activity schedules depending on…

机器学习 · 计算机科学 2025-12-05 Fred Shone , Tim Hillel

A data-driven framework is proposed towards the end of predictive modeling of complex spatio-temporal dynamics, leveraging nested non-linear manifolds. Three levels of neural networks are used, with the goal of predicting the future state…

计算物理 · 物理学 2020-09-14 Jiayang Xu , Karthik Duraisamy

Learning representations of underlying environmental dynamics from partial observations is a critical challenge in machine learning. In the context of Partially Observable Markov Decision Processes (POMDPs), state representations are often…

机器学习 · 计算机科学 2024-11-13 Chao Han , Debabrota Basu , Michael Mangan , Eleni Vasilaki , Aditya Gilra

Latent neural stochastic differential equations (SDEs) have recently emerged as a promising approach for learning generative models from stochastic time series data. However, they systematically underestimate the noise level inherent in…

机器学习 · 计算机科学 2025-06-11 Linus Heck , Maximilian Gelbrecht , Michael T. Schaub , Niklas Boers

Discovering the complete set of causal relations among a group of variables is a challenging unsupervised learning problem. Often, this challenge is compounded by the fact that there are latent or hidden confounders. When only observational…

机器学习 · 计算机科学 2021-01-19 Anqi Liu , Hao Liu , Tongxin Li , Saeed Karimi-Bidhendi , Yisong Yue , Anima Anandkumar

Sequential modelling of high-dimensional data is an important problem that appears in many domains including model-based reinforcement learning and dynamics identification for control. Latent variable models applied to sequential data…

机器学习 · 计算机科学 2023-01-23 Oliver Limoyo , Trevor Ablett , Jonathan Kelly

Variational Auto-Encoders (VAEs) are capable of learning latent representations for high dimensional data. However, due to the i.i.d. assumption, VAEs only optimize the singleton variational distributions and fail to account for the…

机器学习 · 计算机科学 2020-04-20 Da Tang , Dawen Liang , Tony Jebara , Nicholas Ruozzi

We propose a probabilistic framework for developing computational models of biological neural systems. In this framework, physiological recordings are viewed as discrete-time partial observations of an underlying continuous-time stochastic…

神经元与认知 · 定量生物学 2026-02-10 Ahmed ElGazzar , Marcel van Gerven

Partial differential equations, and their chaotic solutions, are pervasive in the modelling of complex systems in engineering, science, and beyond. Data-driven methods can find solutions to partial differential equations with a…

混沌动力学 · 物理学 2024-10-02 Elise Özalp , Luca Magri

The process of generating data such as images is controlled by independent and unknown factors of variation. The retrieval of these variables has been studied extensively in the disentanglement, causal representation learning, and…

机器学习 · 计算机科学 2023-09-26 Gaël Gendron , Michael Witbrock , Gillian Dobbie

Neural conversation models such as encoder-decoder models are easy to generate bland and generic responses. Some researchers propose to use the conditional variational autoencoder(CVAE) which maximizes the lower bound on the conditional…

计算与语言 · 计算机科学 2019-11-25 Jun Gao , Wei Bi , Xiaojiang Liu , Junhui Li , Guodong Zhou , Shuming Shi

Synthetic tabular data are often evaluated by distributional similarity, privacy distance, or train-on-synthetic-test-on-real predictive performance, but these criteria do not ensure validity for causal inference. We show that fully…

统计方法学 · 统计学 2026-05-12 Yichen Xu