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Consider the problem of testing multiple null hypotheses. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($FWER$), the probability of even one…

统计理论 · 数学 2007-06-13 Joseph P. Romano , Azeem M. Shaikh

Controlled variable selection is an important analytical step in various scientific fields, such as brain imaging or genomics. In these high-dimensional data settings, considering too many variables leads to poor models and high costs,…

统计方法学 · 统计学 2023-10-17 Alexandre Blain , Bertrand Thirion , Olivier Grisel , Pierre Neuvial

Despite the popularity of the false discovery rate (FDR) as an error control metric for large-scale multiple testing, its close Bayesian counterpart the local false discovery rate (lfdr), defined as the posterior probability that a…

统计方法学 · 统计学 2023-09-22 Jake A. Soloff , Daniel Xiang , William Fithian

We address the multiple testing problem under the assumption that the true/false hypotheses are driven by a Hidden Markov Model (HMM), which is recognized as a fundamental setting to model multiple testing under dependence since the seminal…

统计方法学 · 统计学 2021-05-04 Marie Perrot-Dockès , Gilles Blanchard , Pierre Neuvial , Etienne Roquain

When testing many hypotheses, often we do not have strong expectations about the directions of the effects. In some situations however, the alternative hypotheses are that the parameters lie in a certain direction or interval, and it is in…

统计方法学 · 统计学 2026-03-02 Jesse Hemerik

In this article, we propose a generalized weighted version of the well-known Benjamini-Hochberg (BH) procedure. The rigorous weighting scheme used by our method enables it to encode structural information from simultaneous multi-way…

统计方法学 · 统计学 2021-05-25 Shinjini Nandi , Sanat K. Sarkar

Conformal selection (CS) uses calibration data to identify test inputs whose unobserved outcomes are likely to satisfy a pre-specified minimal quality requirement, while controlling the false discovery rate (FDR). Existing methods fix the…

机器学习 · 计算机科学 2026-04-20 Meiyi Zhu , Osvaldo Simeone

Multiple testing has been a popular topic in statistical research. Although vast works have been done, controlling the false discoveries remains a challenging task when the corresponding test statistics are dependent. Various methods have…

统计理论 · 数学 2022-07-05 Meng Mei , Tao Yu , Yuan Jiang

How to weigh the Benjamini-Hochberg procedure? In the context of multiple hypothesis testing, we propose a new step-wise procedure that controls the false discovery rate (FDR) and we prove it to be more powerful than any weighted…

统计理论 · 数学 2009-07-13 Etienne Roquain , Mark Van De Wiel

Multiple tests are designed to test a whole collection of null hypotheses simultaneously. Their quality is often judged by the false discovery rate (FDR), i.e. the expectation of the quotient of the number of false rejections divided by the…

统计理论 · 数学 2015-11-24 Julia Benditkis , Philipp Heesen , Arnold Janssen

False discovery rate (FDR) is a cornerstone of modern multiple testing. However, it often fails to guarantee the reliability of "marginal" discoveries that lie at the boundary of the rejection set, which are often crucial in high-precision…

统计方法学 · 统计学 2026-05-12 Yifan Zhang , Wentao Zhang , Changliang Zou , Haojie Ren

Large-scale multiple testing with highly correlated test statistics arises frequently in many scientific research. Incorporating correlation information in estimating false discovery proportion has attracted increasing attention in recent…

统计方法学 · 统计学 2019-03-28 Jianqing Fan , Xu Han

We consider the problem of multiple hypothesis testing with generic side information: for each hypothesis $H_i$ we observe both a p-value $p_i$ and some predictor $x_i$ encoding contextual information about the hypothesis. For large-scale…

统计方法学 · 统计学 2018-07-26 Lihua Lei , William Fithian

Inequalities are key tools to prove FDR control of a multiple test. The present paper studies upper and lower bounds for the FDR under various dependence structures of p-values, namely independence, reverse martingale dependence and…

统计理论 · 数学 2015-02-18 Philipp Heesen , Arnold Janssen

Modern biomedical research frequently involves testing multiple related hypotheses, while maintaining control over a suitable error rate. In many applications the false discovery rate (FDR), which is the expected proportion of false…

统计方法学 · 统计学 2018-09-27 David S. Robertson , James M. S. Wason

The Benjamini-Hochberg (BH) procedure remains widely popular despite having limited theoretical guarantees in the commonly encountered scenario of correlated test statistics. Of particular concern is the possibility that the method could…

统计理论 · 数学 2023-11-14 Dan M. Kluger , Art B. Owen

The False Discovery Rate (FDR) paradigm aims to attain certain control on Type I errors with relatively high power for multiple hypothesis testing. The Benjamini--Hochberg (BH) procedure is a well-known FDR controlling procedure. Under a…

统计理论 · 数学 2007-11-06 Zhiyi Chi

Conformal novelty detection is a classical machine learning task for which uncertainty quantification is essential for providing reliable results. Recent work has shown that the BH procedure applied to conformal p-values controls the false…

统计方法学 · 统计学 2026-03-16 Zijun Gao , Etienne Roquain , Daniel Xiang

We consider statistical hypothesis testing simultaneously over a fairly general, possibly uncountably infinite, set of null hypotheses, under the assumption that a suitable single test (and corresponding $p$-value) is known for each…

统计方法学 · 统计学 2014-02-10 Gilles Blanchard , Sylvain Delattre , Etienne Roquain

We study the convergence of the false discovery proportion (FDP) of the Benjamini-Hochberg procedure in the Gaussian equi-correlated model, when the correlation $\rho_m$ converges to zero as the hypothesis number $m$ grows to infinity. By…

统计理论 · 数学 2010-07-26 Sylvain Delattre , Etienne Roquain