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Stepped-wedge designs are increasingly used in randomized experiments to accommodate logistical and ethical constraints by staggering treatment roll-out over time. Despite their popularity, existing analytical methods largely rely on…

统计方法学 · 统计学 2026-02-12 Liangbo Lyu , Bingkai Wang

Accurately predicting blood glucose (BG) levels of ICU patients is critical, as both hypoglycemia (BG < 70 mg/dL) and hyperglycemia (BG > 180 mg/dL) are associated with increased morbidity and mortality. This study presents a…

机器学习 · 计算机科学 2025-06-24 Hadi Mehdizavareh , Arijit Khan , Simon Lebech Cichosz

Nonlinear mixed effects models represent a powerful tool to simultaneously analyze data from several individuals. In this study a compartmental model of leucine kinetics is examined and extended with a stochastic differential equation to…

定量方法 · 定量生物学 2011-01-05 Martin Berglund , Mikael Sunnåker , Martin Adiels , Mats Jirstrand , Bernt Wennberg

We present a novel method to improve pharmacokinetics modeling, an essential step of drug development. Conventional models frequently fail to fully represent the intricacies of drug absorption and distribution, which limits their predictive…

定量方法 · 定量生物学 2024-12-31 Nazanin Ahmadi , Shupeng Wang , George Karniadakis

An accurate and detailed account of patient medications, including medication changes within the patient timeline, is essential for healthcare providers to provide appropriate patient care. Healthcare providers or the patients themselves…

Self-conditioning has been central to the success of continuous diffusion language models, as it allows models to correct previous errors. Yet its ability degrades precisely in the regime where diffusion is most attractive for deployment:…

计算与语言 · 计算机科学 2026-04-08 Dat Nguyen-Cong , Tung Kieu , Hoang Thanh-Tung

We introduce AutoGraph, a scalable autoregressive model for attributed graph generation using decoder-only transformers. By flattening graphs into random sequences of tokens through a reversible process, AutoGraph enables modeling graphs as…

机器学习 · 计算机科学 2025-12-09 Dexiong Chen , Markus Krimmel , Karsten Borgwardt

Autoregressive (AR) models have shown great promise in image generation, yet they face a fundamental inefficiency stemming from their core component: a vast, unstructured vocabulary of visual tokens. This conventional approach treats tokens…

计算机视觉与模式识别 · 计算机科学 2025-10-07 Lixuan He , Shikang Zheng , Linfeng Zhang

Medical datasets are typically affected by issues such as missing values, class imbalance, a heterogeneous feature types, and a high number of features versus a relatively small number of samples, preventing machine learning models from…

We propose a new class of waveform foundation models that departs from conventional sequence based representations by modeling physiological time series as realizations of latent event processes. Rather than treating signals as collections…

机器学习 · 计算机科学 2026-05-12 Li Na , Yuanyun Zhang , Shi Li

We study goodness-of-fit testing for non-causal autoregressive time series with non-Gaussian stable noise. To model time series exhibiting sharp spikes or occasional bursts of outlying observations, the exponent of the non-Gaussian stable…

统计理论 · 数学 2012-09-19 Yunwei Cui , Rongning Wu , Thomas J. Fisher

While generative models have recently become ubiquitous in many scientific areas, less attention has been paid to their evaluation. For molecular generative models, the state-of-the-art examines their output in isolation or in relation to…

Computational biomarkers (CBs) are histopathology-derived patterns extracted from hematoxylin-eosin (H&E) whole-slide images (WSIs) using artificial intelligence (AI) to predict therapeutic response or prognosis. Recently, slide-level…

This article proposes a Model Reference Adaptive Control (MRAC) strategy to achieve fixed-time convergence of parameter estimation and tracking errors for unknown linear time-invariant systems, without relying on the persistence of…

系统与控制 · 电气工程与系统科学 2026-04-23 Chayan Kumar Paul , Krishanu Nath , Indra Narayan Kar , Denis Efimov , Rosane Ushirobira

Using observational data to estimate the effect of a treatment is a powerful tool for decision-making when randomized experiments are infeasible or costly. However, observational data often yields biased estimates of treatment effects,…

统计方法学 · 统计学 2022-03-01 Tobias Hatt , Stefan Feuerriegel

High-frequency physiological waveform modality offers deep, real-time insights into patient status. Recently, physiological foundation models based on Photoplethysmography (PPG), such as PPG-GPT, have been shown to predict critical events,…

机器学习 · 计算机科学 2025-09-29 Saurabh Kataria , Davood Fattahi , Minxiao Wang , Ran Xiao , Matthew Clark , Timothy Ruchti , Mark Mai , Xiao Hu

We introduce Heptapod, an image autoregressive model that adheres to the foundational principles of language modeling. Heptapod employs \textbf{causal attention}, \textbf{eliminates reliance on CFG}, and \textbf{eschews the trend of…

计算机视觉与模式识别 · 计算机科学 2025-10-09 Yongxin Zhu , Jiawei Chen , Yuanzhe Chen , Zhuo Chen , Dongya Jia , Jian Cong , Xiaobin Zhuang , Yuping Wang , Yuxuan Wang

AI procedures joined with wearable gadgets can convey exact transient blood glucose level forecast models. Also, such models can learn customized glucose-insulin elements dependent on the sensor information gathered by observing a few parts…

机器学习 · 计算机科学 2021-01-22 Ignacio Rodriguez

Data-driven medical AI is traditionally formulated as a discriminative mapping from input $X$ to output $Y$ via a learned function $f$, which does not generalize well across heterogeneous data and modalities encountered in real-world…

计算机视觉与模式识别 · 计算机科学 2026-05-12 Hantao Zhang , Weidong Guo , Yuhe Liu , Jiancheng Yang , Sathvik Bhagavan , Danli Shi , Mingda Xu , Pascal Fua

Classifier-free guidance (CFG) has become a widely adopted and practical approach for enhancing generation quality and improving condition alignment. Recent studies have explored guidance mechanisms for unconditional generation, yet these…

计算机视觉与模式识别 · 计算机科学 2025-12-01 Chaoyang Wang , Tianmeng Yang , Jingdong Wang , Yunhai Tong