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Proton therapy provides superior dose conformity compared with photon radiotherapy, concentrating radiation within the tumor while sparing adjacent healthy tissue. This advantage has been most effectively realized for static tumors in…

医学物理 · 物理学 2025-10-09 Vivek Maradia , Nick Yue , Adam Molzahn , Jingqian Wang , Mark Pankuch , Serdar Charyyev , Billy W. Loo

The physical and clinical benefits of charged particle therapy (CPT) are well recognised and recent developments have led to the rapid emergence of facilities, resulting in wider adoption worldwide. Nonetheless, the availability of CPT and…

医学物理 · 物理学 2021-12-17 Jacinta Yap , Andrea De Franco , Suzie Sheehy

Laser acceleration promises innovation in particle beam therapy of cancer where an ultra-compact accelerator system for cancer beam therapy can become affordable to a broad range of patients. This is not feasible without the introduction of…

Recent developments for the delivery of proton and ion beam therapy have been significant, and a number of technological solutions now exist for the creation and utilisation of these particles for the treatment of cancer. In this paper we…

加速器物理 · 物理学 2015-06-17 Hywel Owen , David Holder , Jose Alonso , Ranald MacKay

The field of particle therapy is quickly growing and yet it's more widespread adoption is limited by size, cost and adaptation to the more conformal treatment techniques. In order to realize the benefits of this modality the equipment used…

医学物理 · 物理学 2018-04-25 Jay Flanz

Hadrontherapy is a novel technique of cancer radiation therapy which employs beams of charged hadrons, protons and carbon ions in particular. Due to their physical and radiobiological properties, they allow one to obtain a more conformal…

医学物理 · 物理学 2015-05-14 Saverio Braccini

Treatment delivery is largely determined by capabilities of the beam delivery system (BDS), where faster delivery can have many potential benefits including improved dosimetric quality, utility, cost effectiveness, patient throughput and…

医学物理 · 物理学 2026-01-21 Jacinta Yap , Adam Steinberg , Hannah Norman , Konrad Nesteruk , Suzie Sheehy

The radiotherapy of malignant diseases has reached much progress during the past decade. Thus, intensity modulated radiation therapy (IMRT) and VMAT (Rapidarc) now belong to the standard modalities of tumor treatment with high energy…

医学物理 · 物理学 2016-11-15 W. Ulmer , A. Carabe-Fernandez

Particle physics simulations are the cornerstone of nuclear engineering applications. Among them radiotherapy (RT) is crucial for society, with 50% of cancer patients receiving radiation treatments. For the most precise targeting of tumors,…

机器学习 · 计算机科学 2021-09-10 Oscar Pastor-Serrano , Zoltán Perkó

Proton therapy is a cancer treatment technique currently in growth worldwide. It offers advantages with respect to conventional X-ray and $\gamma$-ray radiotherapy, in particular, a better control of the dose deposition allowing to reach a…

Purpose: The FLASH effect, which reduces the radiosensitivity of healthy tissue while maintaining tumor control at high dose rates, has shown potential for improving radiation therapy. Conformal FLASH proton therapy involves advanced…

医学物理 · 物理学 2023-04-13 Sylvain Deffet , Edmond Sterpin

In this work, we present a fundamental mathematical model for proton transport, tailored to capture the key physical processes underpinning Proton Beam Therapy (PBT). The model provides a robust and computationally efficient framework for…

Cancer therapy using protons and heavier ions such as carbon has demonstrated advantages over other radiotherapy treatments. To bring about the next generation of clinical facilities, the requirements are likely to reduce the footprint,…

加速器物理 · 物理学 2021-05-19 H. X. Q. Norman , A. F. Steinberg , R. B. Appleby , H. L. Owen , E. Benedetto , M. Sapinski , S. L. Sheehy

Proton (and ion) cancer therapy has proven to be an extremely effective even supe-rior method of treatment for some tumors 1-4. A major problem, however, lies in the cost of the particle accelerator facilities; high procurement costs…

The question of whether or not neutron therapy works has been answered. It is a qualified yes, as is the case with all of radiation therapy. But, neutron therapy has not kept pace with the rest of radiation therapy in terms of beam delivery…

医学物理 · 物理学 2014-09-09 Thomas K. Kroc , James S. Welsh

Radiotherapy is one of the main methods in the successful treatment of cancer. The tumor is irradiated with photons or charged particles (e.g. protons), and in the case of massive charged particles, the treatment results in less unnecessary…

医学物理 · 物理学 2019-03-20 Monika Varga-Kofarago

Purpose: Proton therapy provides superior dose conformity compared to photon therapy, but its treatment planning is challenged by sensitivity to anatomical changes, setup/range uncertainties, and computational complexity. This review…

Large scale directed energy offers the possibility of radical transformation in a variety of areas, including the ability to achieve relativistic flight that will enable the first interstellar missions, as well as rapid interplanetary…

综合经济学 · 经济学 2022-01-13 Philip Lubin , Alexander N. Cohen

The beam transport system between accelerator and patient treatment location in a particle therapy facility is described. After some general layout aspects the major beam handling tasks of this system are discussed. These are energy…

医学物理 · 物理学 2018-04-24 Jacobus Maarten Schippers

This report presents a design of a gantry for proton therapy based on the concept of adiabatic transition. The use of fixed-field alternating gradient magnets allows a large momentum acceptance and supports fast energy modulation. The…

加速器物理 · 物理学 2021-05-13 Titus-Stefan Dascalu , Suzanne L. Sheehy
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