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In some causal inference scenarios, the treatment variable is measured inaccurately, for instance in epidemiology or econometrics. Failure to correct for the effect of this measurement error can lead to biased causal effect estimates.…

机器学习 · 计算机科学 2024-09-13 Antti Pöllänen , Pekka Marttinen

Under a composite estimand strategy, the occurrence of the intercurrent event is incorporated into the endpoint definition, for instance by assigning a poor outcome value to patients who experience the event. Composite strategies are…

统计方法学 · 统计学 2025-07-01 Brennan C Kahan , Tra My Pham , Conor Tweed , Tim P Morris

Heterogeneous treatment effects can be very important in the analysis of randomized clinical trials. Heightened risks or enhanced benefits may exist for particular subsets of study subjects. When the heterogeneous treatment effects are…

统计方法学 · 统计学 2025-07-25 Richard A. Berk , Matthew Olson , Andreas Buja , Aurelie Ouss

Applied researchers are increasingly interested in whether and how treatment effects vary in randomized evaluations, especially variation not explained by observed covariates. We propose a model-free approach for testing for the presence of…

统计方法学 · 统计学 2014-12-17 Peng Ding , Avi Feller , Luke Miratrix

The estimation of individual treatment effects (ITE) focuses on predicting the outcome changes that result from a change in treatment. A fundamental challenge in observational data is that while we need to infer outcome differences under…

机器学习 · 计算机科学 2025-12-23 Zichuan Lin , Xiaokai Huang , Jiate Liu , Yuxuan Han , Jia Chen , Xiapeng Wu , Deheng Ye

We describe and contrast two distinct problem areas for statistical causality: studying the likely effects of an intervention ("effects of causes"), and studying whether there is a causal link between the observed exposure and outcome in an…

统计理论 · 数学 2021-04-02 A. Philip Dawid , Monica Musio

Sustained treatment strategies are common in many domains, particularly in medicine, where many treatment are delivered repeatedly over time. The effects of adherence to a treatment strategy throughout follow-up are often more relevant to…

Causal identification of treatment effects for infectious disease outcomes in interconnected populations is challenging because infection outcomes may be transmissible to others, and treatment given to one individual may affect others'…

统计方法学 · 统计学 2021-05-11 Xiaoxuan Cai , Eben Kenah , Forrest W. Crawford

Two problems that arise in making causal inferences for non-mortality outcomes such as bronchopulmonary dysplasia (BPD) are unmeasured confounding and censoring by death, i.e., the outcome is only observed when subjects survive. In…

统计方法学 · 统计学 2018-02-20 Kwonsang Lee , Scott A. Lorch , Dylan S. Small

We consider estimation and inference of the effects of a policy in the absence of an untreated or control group. We obtain unbiased estimators of individual (heterogeneous) treatment effects and a consistent and asymptotically normal…

计量经济学 · 经济学 2026-01-13 Irene Botosaru , Raffaella Giacomini , Martin Weidner

In many scientific contexts, different investigators experiment with or observe different variables with data from a domain in which the distinct variable sets might well be related. This sort of fragmentation sometimes occurs in molecular…

人工智能 · 计算机科学 2019-09-05 Shuyan Wang

The analysis of randomized trials is often complicated by the occurrence of intercurrent events and missing values. Even though there are different strategies to address missing values it is still common to require missing values…

统计方法学 · 统计学 2025-11-11 A. Ruiz de Villa , Ll. Badiella

Recurrent events, including cardiovascular events, are commonly observed in biomedical studies. Researchers must understand the effects of various treatments on recurrent events and investigate the underlying mediation mechanisms by which…

统计方法学 · 统计学 2025-07-08 Yan-Lin Chen , Yan-Hong Chen , Pei-Fang Su , Huang-Tz Ou , An-Shun Tai

In longitudinal studies where units are embedded in space or a social network, interference may arise, meaning that a unit's outcome can depend on treatment histories of others. The presence of interference poses significant challenges for…

统计方法学 · 统计学 2025-08-26 Ye Wang , Michael Jetsupphasuk

Many applications of causal analysis call for assessing, retrospectively, the effect of withholding an action that has in fact been implemented. This counterfactual quantity, sometimes called "effect of treatment on the treated," (ETT) have…

统计方法学 · 统计学 2012-05-14 Ilya Shpitser , Judea Pearl

Even in a carefully designed randomized trial, outcomes for some study participants can be missing, or more precisely, ill-defined, because participants had died prior to date of outcome collection. This problem, known as truncation by…

统计方法学 · 统计学 2022-09-27 Tamir Zehavi , Daniel Nevo

We develop a Bayesian nonparametric (BNP) approach to evaluate the causal effect of treatment in a randomized trial where a nonterminal event may be censored by a terminal event, but not vice versa (i.e., semi-competing risks). Based on the…

统计方法学 · 统计学 2019-07-23 Yanxun Xu , Daniel Scharfstein , Peter Müller , Michael Daniels

Understanding and quantifying cause and effect is an important problem in many domains. The generally-agreed solution to this problem is to perform a randomised controlled trial. However, even when randomised controlled trials can be…

机器学习 · 统计学 2023-02-22 Graham Van Goffrier , Lucas Maystre , Ciarán Gilligan-Lee

Causal effect estimation seeks to determine the impact of an intervention from observational data. However, the existing causal inference literature primarily addresses treatment effects on frequently occurring events. But what if we are…

机器学习 · 统计学 2025-06-18 Jiyuan Tan , Jose Blanchet , Vasilis Syrgkanis

Evaluating treatment effect heterogeneity widely informs treatment decision making. At the moment, much emphasis is placed on the estimation of the conditional average treatment effect via flexible machine learning algorithms. While these…

统计方法学 · 统计学 2021-05-07 Lihua Lei , Emmanuel J. Candès