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Managing physiological variables within clinically safe target zones is a central challenge in healthcare, particularly for chronic conditions such as Type 1 Diabetes Mellitus (T1DM). Reinforcement learning (RL) offers promise for…

机器学习 · 计算机科学 2025-08-07 David H. Mguni , Jing Dong , Wanrong Yang , Ziquan Liu , Muhammad Salman Haleem , Baoxiang Wang

The widespread adoption of effective hybrid closed loop systems would represent an important milestone of care for people living with type 1 diabetes (T1D). These devices typically utilise simple control algorithms to select the optimal…

机器学习 · 计算机科学 2023-05-08 Harry Emerson , Matthew Guy , Ryan McConville

People with type 1 diabetes (T1D) lack the ability to produce the insulin their bodies need. As a result, they must continually make decisions about how much insulin to self-administer to adequately control their blood glucose levels.…

机器学习 · 计算机科学 2020-09-22 Ian Fox , Joyce Lee , Rodica Pop-Busui , Jenna Wiens

This paper presents a novel multi-agent reinforcement learning (RL) approach for personalized glucose control in individuals with type 1 diabetes (T1D). The method employs a closed-loop system consisting of a blood glucose (BG) metabolic…

机器学习 · 计算机科学 2023-07-24 Mehrad Jaloli , Marzia Cescon

People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring…

信号处理 · 电气工程与系统科学 2020-09-08 Taiyu Zhu , Kezhi Li , Pau Herrero , Pantelis Georgiou

In this paper we investigate the use of model-based reinforcement learning to assist people with Type 1 Diabetes with insulin dose decisions. The proposed architecture consists of multiple Echo State Networks to predict blood glucose levels…

Automated insulin delivery for Type 1 Diabetes must balance glucose control and safety under uncertain meals and physiological variability. While reinforcement learning (RL) enables adaptive personalization, existing approaches struggle to…

机器学习 · 计算机科学 2026-01-23 Yushen Liu , Yanfu Zhang , Xugui Zhou

People with type 1 diabetes (T1D) struggle to calculate the optimal insulin dose at mealtime, especially when under multiple daily injections (MDI) therapy. Effectively, they will not always perform rigorous and precise calculations, but…

人工智能 · 计算机科学 2023-09-19 Anas El Fathi , Marc D. Breton

Type I Diabetes (T1D) is a chronic disease in which the body's ability to synthesize insulin is destroyed. It can be difficult for patients to manage their T1D, as they must control a variety of behavioral factors that affect glycemic…

计算机科学中的逻辑 · 计算机科学 2019-06-25 Josephine Lamp , Simone Silvetti , Marc Breton , Laura Nenzi , Lu Feng

Reinforcement learning (RL) has demonstrated success in automating insulin dosing in simulated type 1 diabetes (T1D) patients but is currently unable to incorporate patient expertise and preference. This work introduces PAINT (Preference…

人工智能 · 计算机科学 2025-01-28 Harry Emerson , Sam Gordon James , Matthew Guy , Ryan McConville

Type 1 diabetes mellitus (T1D) is characterized by insulin deficiency and blood glucose (BG) control issues. The state-of-the-art solution for continuous BG control is reinforcement learning (RL), where an agent can dynamically adjust…

机器学习 · 计算机科学 2026-01-26 Jingchi Jiang , Rujia Shen , Boran Wang , Yi Guan

We propose a dual-hormone delivery strategy by exploiting deep reinforcement learning (RL) for people with Type 1 Diabetes (T1D). Specifically, double dilated recurrent neural networks (RNN) are used to learn the hormone delivery strategy,…

定量方法 · 定量生物学 2019-10-10 Taiyu Zhu , Kezhi Li , Pantelis Georgiou

Comorbid chronic conditions are common among people with type 2 diabetes. We developed an Artificial Intelligence algorithm, based on Reinforcement Learning (RL), for personalized diabetes and multi-morbidity management with strong…

计算机与社会 · 计算机科学 2020-11-05 Hua Zheng , Ilya O. Ryzhov , Wei Xie , Judy Zhong

Self-monitoring of blood glucose (SMBG) and continuous glucose monitoring (CGM) are commonly used by type 1 diabetes (T1D) patients to measure glucose concentrations. The proposed adaptive basal-bolus algorithm (ABBA) supports inputs from…

系统与控制 · 电气工程与系统科学 2024-12-20 Qingnan Sun , Marko V. Jankovic , João Budzinski , Brett Moore , Peter Diem , Christoph Stettler , Stavroula G. Mougiakakou

This paper proposes a robust control design method using reinforcement-learning for controlling partially-unknown dynamical systems under uncertain conditions. The method extends the optimal reinforcement-learning algorithm with a new…

系统与控制 · 电气工程与系统科学 2020-04-17 Phuong D. Ngo , Fred Godtliebsen

Patients with diabetes who are self-monitoring have to decide right before each meal how much insulin they should take. A standard bolus advisor exists, but has never actually been proven to be optimal in any sense. We challenged this rule…

机器学习 · 统计学 2020-07-24 Frédéric Logé , Erwan Le Pennec , Habiboulaye Amadou-Boubacar

Effective management of Type 1 Diabetes requires continuous glucose monitoring and precise insulin adjustments to prevent hyperglycemia and hypoglycemia. With the growing adoption of wearable glucose monitors and mobile health applications,…

机器学习 · 计算机科学 2026-01-22 Giorgia Rigamonti , Mirko Paolo Barbato , Davide Marelli , Paolo Napoletano

Calculating mealtime insulin doses poses a significant challenge for individuals with Type 1 Diabetes (T1D). Doses should perfectly compensate for expected post-meal glucose excursions, requiring a profound understanding of the individual's…

定量方法 · 定量生物学 2024-06-24 Anas El Fathi , Elliott Pryor , Marc D. Breton

Blood Glucose (BG) control involves keeping an individual's BG within a healthy range through extracorporeal insulin injections is an important task for people with type 1 diabetes. However,traditional patient self-management is cumbersome…

人工智能 · 计算机科学 2024-03-18 Weiwei Gu , Senquan Wang

Type 1 Diabetes (T1D) is an autoimmune disease leading to insulin insufficiency. Thus, patients require lifelong insulin therapy, which has a side effect of hypoglycemia. Hypoglycemia is a critical state of decreased blood glucose levels…

机器学习 · 计算机科学 2026-01-21 Beyza Cinar , Louisa van den Boom , Maria Maleshkova
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