相关论文: SNPgen: Phenotype-Supervised Genotype Representati…

We propose a categorical data synthesizer with a quantifiable disclosure risk. Our algorithm, named Perturbed Gibbs Sampler, can handle high-dimensional categorical data that are often intractable to represent as contingency tables. The…

Semi-supervised learning (SSL) is a promising approach for training deep classification models using labeled and unlabeled datasets. However, existing SSL methods rely on a large unlabeled dataset, which may not always be available in many…

This paper introduces a methodology for generating synthetic annotated data to address data scarcity in semantic segmentation tasks within the precision agriculture domain. Utilizing Denoising Diffusion Probabilistic Models (DDPMs) and…

The widespread adoption of electronic health records and digital healthcare data has created a demand for data-driven insights to enhance patient outcomes, diagnostics, and treatments. However, using real patient data presents privacy and…

Generating high-fidelity synthetic tabular data under formal differential privacy guarantees remains an open challenge. Methods that provide strong theoretical protection typically sacrifice the modeling of inter-feature dependencies…

Machine-generated data is a valuable resource for training Artificial Intelligence algorithms, evaluating rare workflows, and sharing data under stricter data legislations. The challenge is to generate data that is accurate and private.…

Background: Synthetic data has been proposed as a solution for sharing anonymized versions of sensitive biomedical datasets. Ideally, synthetic data should preserve the structure and statistical properties of the original data, while…

In this paper, association results from genome-wide association studies (GWAS) are combined with a deep learning framework to test the predictive capacity of statistically significant single nucleotide polymorphism (SNPs) associated with…

Recent advances in high-resolution sequencing have paved the way for population-scale analysis in single-cell RNA-sequencing (scRNA-seq) data. scRNA-seq data, in particular, have proven to be extremely powerful in profiling a variety of…

Radiogenomic map linking image features and gene expression profiles is useful for noninvasively identifying molecular properties of a particular type of disease. Conventionally, such map is produced in three separate steps: 1)…

With the rising adoption of Machine Learning across the domains like banking, pharmaceutical, ed-tech, etc, it has become utmost important to adopt responsible AI methods to ensure models are not unfairly discriminating against any group.…

We present a novel approach for generating minority samples that live on low-density regions of a data manifold. Our framework is built upon diffusion models, leveraging the principle of guided sampling that incorporates an arbitrary…

Sharing of tabular data containing valuable but private information is limited due to legal and ethical issues. Synthetic data could be an alternative solution to this sharing problem, as it is artificially generated by machine learning…

Genome-wide association studies (GWAS) are an essential tool in biomedical research for identifying genetic factors linked to health and disease. However, publicly releasing GWAS summary statistics poses well-recognized privacy risks,…

Achieving robust performance and fairness across diverse patient populations remains a challenge in developing clinically deployable deep learning models for diagnostic imaging. Synthetic data generation has emerged as a promising strategy…

We present an approach for generating differentially private synthetic text using large language models (LLMs), via private prediction. In the private prediction framework, we only require the output synthetic data to satisfy differential…

Synthetic data generation in histopathology faces unique challenges: preserving tissue heterogeneity, capturing subtle morphological features, and scaling to unannotated datasets. We present a latent diffusion model that generates realistic…

Identifying disease-associated genes enables the development of precision medicine and the understanding of biological processes. Genome-wide association studies (GWAS), gene expression data, biological pathway analysis, and protein network…

High-quality synthetic data can support the development of effective predictive models for biomedical tasks, especially in rare diseases or when subject to compelling privacy constraints. These limitations, for instance, negatively impact…

When testing for the association of a single SNP with a phenotypic response, one usually considers an additive genetic model, assuming that the mean of of the response for the heterozygous state is the average of the means for the two…