相关论文: RexDrug: Reliable Multi-Drug Combination Extractio…

Combination drug therapies are treatment regimens that involve two or more drugs, administered more commonly for patients with cancer, HIV, malaria, or tuberculosis. Currently there are over 350K articles in PubMed that use the "combination…

Reinforcement learning (RL) is emerging as a powerful paradigm for enabling large language models (LLMs) to perform complex reasoning tasks. Recent advances indicate that integrating RL with retrieval-augmented generation (RAG) allows LLMs…

The integration of Large Language Models (LLMs) into healthcare is constrained by knowledge limitations, hallucinations, and a disconnect from Evidence-Based Medicine (EBM). While Retrieval-Augmented Generation (RAG) offers a solution,…

Extracting structured information from unstructured text is critical for many downstream NLP applications and is traditionally achieved by closed information extraction (cIE). However, existing approaches for cIE suffer from two…

Retrieval-augmented generation (RAG) is key to enhancing large language models (LLMs) to systematically access richer factual knowledge. Yet, using RAG brings intrinsic challenges, as LLMs must deal with potentially conflicting knowledge,…

Drug discovery is a critical task in biomedical natural language processing (NLP), yet explainable drug discovery remains underexplored. Meanwhile, large language models (LLMs) have shown remarkable abilities in natural language…

Drug-drug interaction (DDI) prediction is critical for treatment safety. While large language models (LLMs) show promise in pharmaceutical tasks, their effectiveness in DDI prediction remains challenging. Inspired by the well-established…

Document-level relation extraction (Doc-RE) aims to extract relations between entities across multiple sentences. Therefore, Doc-RE requires more comprehensive reasoning abilities like humans, involving complex cross-sentence interactions…

Drug-drug interaction (DDI) is a vital information when physicians and pharmacists intend to co-administer two or more drugs. Thus, several DDI databases are constructed to avoid mistakenly combined use. In recent years, automatically…

Relation extraction between drugs plays a crucial role in identifying drug drug interactions and predicting side effects. The advancement of machine learning methods in relation extraction, along with the development of large medical text…

Document-Level Biomedical Relation Extraction (Bio-RE) aims to identify relations between biomedical entities within extensive texts, serving as a crucial subfield of biomedical text mining. Existing Bio-RE methods struggle with…

Combination therapies have become the standard of care for diseases such as cancer, tuberculosis, malaria and HIV. However, the combinatorial set of available multi-drug treatments creates a challenge in identifying effective combination…

Most information extraction methods focus on binary relations expressed within single sentences. In high-value domains, however, $n$-ary relations are of great demand (e.g., drug-gene-mutation interactions in precision oncology). Such…

Large language model (LLM)-based recommender models that bridge users and items through textual prompts for effective semantic reasoning have gained considerable attention. However, few methods consider the underlying rationales behind…

Molecule generation and optimization is a fundamental task in chemical domain. The rapid development of intelligent tools, especially large language models (LLMs) with powerful knowledge reserves and interactive capabilities, has provided…

Recent advances in large language models (LLMs) have shown great potential to accelerate drug discovery. However, the specialized nature of biochemical data often necessitates costly domain-specific fine-tuning, posing major challenges.…

Biomedical relation extraction (RE) is the task of automatically identifying and characterizing relations between biomedical concepts from free text. RE is a central task in biomedical natural language processing (NLP) research and plays a…

Document-level Relation Extraction (DocRE), which aims to extract relations from a long context, is a critical challenge in achieving fine-grained structural comprehension and generating interpretable document representations. Inspired by…

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Retrieval-Augmented Generation (RAG) systems critically depend on how external knowledge is segmented, structured, and retrieved. Most existing approaches either retrieve fixed-length text chunks, which fragments discourse context, or…