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The social contagion literature makes a distinction between simple (independent cascade or bond percolation processes that pass infections through edges) and complex contagions (bootstrap percolation or threshold processes that require…

社会与信息网络 · 计算机科学 2025-05-05 Vahid Shamsaddini , M. Amin Rahimian

Topological Data Analysis (TDA) is an emergent field that aims to discover topological information hidden in a dataset. TDA tools have been commonly used to create filters and topological descriptors to improve Machine Learning (ML)…

机器学习 · 计算机科学 2021-02-09 Rolando Kindelan , José Frías , Mauricio Cerda , Nancy Hitschfeld

We present a new method for exploring cancer gene expression data based on tools from algebraic topology. Our method selects a small relevant subset from tens of thousands of genes while simultaneously identifying nontrivial higher order…

基因组学 · 定量生物学 2014-10-15 Svetlana Lockwood , Bala Krishnamoorthy

"Concurrence topology" (Ellis and Klein \emph{Homology, Homotopy, and Applications,} \textbf{16}) is a TDA method for binary data. The idea is to construct a filtration consisting of Dowker complexes then compute persistent homology.…

统计理论 · 数学 2017-06-21 Steven P. Ellis

Persistent homology analysis, a recently developed computational method in algebraic topology, is applied to the study of the phase transitions undergone by the so-called XY-mean field model and by the phi^4 lattice model, respectively. For…

In data clustering, it is often desirable to find not just a single partition into clusters but a sequence of partitions that describes the data at different scales (or levels of coarseness). A natural problem then is to analyse and compare…

代数拓扑 · 数学 2025-04-25 Juni Schindler , Mauricio Barahona

Interleaving distances are used widely in Topological Data Analysis (TDA) as a tool for comparing topological signatures of datasets. The theory of interleaving distances has been extended through various category-theoretic constructions,…

代数拓扑 · 数学 2026-01-21 Patrick K. McFaddin , Tom Needham

We study the persistent homology of both functional data on compact topological spaces and structural data presented as compact metric measure spaces. One of our goals is to define persistent homology so as to capture primarily properties…

代数拓扑 · 数学 2018-11-27 Haibin Hang , Facundo Mémoli , Washington Mio

We analyze functionals that characterize the distribution of eigenstates in Fock space through a tool derived from algebraic topology: persistent homology. Drawing on recent generalizations of the localization landscape applicable to…

无序系统与神经网络 · 物理学 2023-02-21 Gregory A. Hamilton , Bryan K. Clark

Genetic mutations frequently disrupt protein structure, stability, and solubility, acting as primary drivers for a wide spectrum of diseases. Despite the critical importance of these molecular alterations, existing computational models…

谱理论 · 数学 2026-01-21 Yiming Ren , Junjie Wee , Xi Chen , Grace Qian , Guo-Wei Wei

Persistent Topology studies topological features of shapes by analyzing the lower level sets of suitable functions, called filtering functions, and encoding the arising information in a parameterized version of the Betti numbers, i.e. the…

代数拓扑 · 数学 2010-05-05 Andrea Cerri , Patrizio Frosini

Self-organized pattern behavior is ubiquitous throughout nature, from fish schooling to collective cell dynamics during organism development. Qualitatively these patterns display impressive consistency, yet variability inevitably exists…

定量方法 · 定量生物学 2022-06-08 Melissa R. McGuirl , Alexandria Volkening , Björn Sandstede

Persistent homology is a tool that can be employed to summarize the shape of data by quantifying homological features. When the data is an object in $\mathbb{R}^d$, the (augmented) persistent homology transform ((A)PHT) is a family of…

计算几何 · 计算机科学 2022-12-27 Brittany Terese Fasy , Samuel Micka , David L. Millman , Anna Schenfisch , Lucia Williams

In this paper, we propose a method that extends the persistence-based topological data analysis (TDA) that is typically used for characterizing shapes to general networks. We introduce the concept of the community tree, a tree structure…

社会与信息网络 · 计算机科学 2022-04-08 Wei Guo , Ruqian Chen , Yen-Chi Chen , Ashis G. Banerjee

Identifying subgroups and properties of cancer biopsy samples is a crucial step towards obtaining precise diagnoses and being able to perform personalized treatment of cancer patients. Recent data collections provide a comprehensive…

基因组学 · 定量生物学 2021-04-23 Stefan Groha , Caroline Weis , Alexander Gusev , Bastian Rieck

The Mapper algorithm, a technique within topological data analysis (TDA), constructs a simplified graphical representation of high-dimensional data to uncover its underlying shape and structural patterns. The algorithm has attracted…

Shape analysis and classification are popular methods for biologists, biophysicists and mathematicians investigating relationships between object function and form. Classic shape descriptors, such as sphericity, can be powerful but may be…

定量方法 · 定量生物学 2025-02-21 Allyson Quinn Ryan , Johannes Soltwedel , Carl D. Modes

Conformational transitions are ubiquitous in biomolecular systems, have significant functional roles and are subject to evolutionary pressures. Here we provide a first theoretical framework for topological transition, i.e. conformational…

无序系统与神经网络 · 物理学 2015-09-02 Alireza Mashaghi , Abolfazl Ramezanpour

Transcriptional activity has been shown to relate to the organization of chromosomes in the eukaryotic nucleus and in the bacterial nucleoid. In particular, highly transcribed genes, RNA polymerases and transcription factors gather into…

生物物理 · 物理学 2010-05-11 Ivan Junier , Olivier Martin , François Képès

A topos theoretic generalisation of the category of sets allows for modelling spaces which vary according to time intervals. Persistent homology, or more generally, persistence is a central tool in topological data analysis, which examines…

环与代数 · 数学 2015-06-23 João Pita Costa , Mikael Vejdemo Johansson , Primož Škraba