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Model-based recursive partitioning (MOB) can be used to identify subgroups with differing treatment effects. The detection rate of treatment-by-covariate interactions and the accuracy of identified subgroups using MOB depend strongly on the…

应用统计 · 统计学 2022-09-07 Cynthia Huber , Norbert Benda , Tim Friede

In recent years, there has been a growing interest in the prediction of individualized treatment effects. While there is a rapidly growing literature on the development of such models, there is little literature on the evaluation of their…

统计方法学 · 统计学 2023-12-22 J Hoogland , O Efthimiou , TL Nguyen , TPA Debray

Reliable uncertainty quantification (UQ) is essential in medical AI. Evidential Deep Learning (EDL) offers a computationally efficient way to quantify model uncertainty alongside predictions, unlike traditional methods such as Monte Carlo…

Multi-agent learning faces a fundamental tension: leveraging distributed collaboration without sacrificing the personalization needed for diverse agents. This tension intensifies when aiming for full personalization while adapting to…

机器学习 · 统计学 2026-03-11 Chenyu Zhang , Navid Azizan

In the absence of data from a randomized trial, researchers often aim to use observational data to draw causal inference about the effect of a treatment on a time-to-event outcome. In this context, interest often focuses on the…

统计方法学 · 统计学 2021-06-15 Ted Westling , Alex Luedtke , Peter Gilbert , Marco Carone

Real world observational data, together with causal inference, allow the estimation of causal effects when randomized controlled trials are not available. To be accepted into practice, such predictive models must be validated for the…

Lung cancer is a condition where there is abnormal growth of malignant cells that spread in an uncontrollable fashion in the lungs. Some common treatment strategies are surgery, chemotherapy, and radiation which aren't the best options due…

计算机视觉与模式识别 · 计算机科学 2026-03-18 Ann Rachel , Pranav M Pawar , Mithun Mukharjee , Raja M , Tojo Mathew

Estimating individual-level treatment effect from observational data is a fundamental problem in causal inference and has attracted increasing attention in the fields of education, healthcare, and public policy.In this work, we concentrate…

机器学习 · 计算机科学 2025-07-10 Hui Meng , Keping Yang , Xuyu Peng , Bo Zheng

While machine learning (ML) methods have received a lot of attention in recent years, these methods are primarily for prediction. Empirical researchers conducting policy evaluations are, on the other hand, pre-occupied with causal problems,…

机器学习 · 统计学 2019-03-04 Noemi Kreif , Karla DiazOrdaz

To enable personalized cancer treatment, machine learning models have been developed to predict drug response as a function of tumor and drug features. However, most algorithm development efforts have relied on cross validation within a…

Automating chest radiograph interpretation using Deep Learning (DL) models has the potential to significantly improve clinical workflows, decision-making, and large-scale health screening. However, in medical settings, merely optimising…

计算与语言 · 计算机科学 2025-05-08 Gianluca Manzo , Julia Ive

Machine learning (ML) is increasingly used to support decision-making in the healthcare sector. While ML approaches provide promising results with regard to their classification performance, most share a central limitation, namely their…

Effective medication management in Parkinson's Disease (PD) is challenging due to heterogeneous disease progression, variable patient response, and medication side effects. While AI models can forecast levodopa equivalent daily dose (LEDD)…

机器学习 · 计算机科学 2026-05-21 Ricardo Diaz-Rincon , Muxuan Liang , Adolfo Ramirez-Zamora , Benjamin Shickel

Human Multimodal Language Understanding (MLU) aims to infer human intentions by integrating related cues from heterogeneous modalities. Existing works predominantly follow a ``learning to attend" paradigm, which maximizes mutual information…

计算与语言 · 计算机科学 2025-09-29 Menghua Jiang , Yuncheng Jiang , Haifeng Hu , Sijie Mai

Current clinical practice guidelines for managing Coronary Artery Disease (CAD) account for general cardiovascular risk factors. However, they do not present a framework that considers personalized patient-specific characteristics. Using…

机器学习 · 统计学 2019-10-21 Dimitris Bertsimas , Agni Orfanoudaki , Rory B. Weiner

Non-linear mixed effects modeling and simulation (NLME M&S) is evaluated to be used for standardization with longitudinal data in presence of confounders. Standardization is a well-known method in causal inference to correct for confounding…

统计方法学 · 统计学 2024-05-01 Christian Bartels , Martina Scauda , Neva Coello , Thomas Dumortier , Bjoern Bornkamp , Giusi Moffa

We propose causal isotonic calibration, a novel nonparametric method for calibrating predictors of heterogeneous treatment effects. Furthermore, we introduce cross-calibration, a data-efficient variant of calibration that eliminates the…

机器学习 · 统计学 2023-06-07 Lars van der Laan , Ernesto Ulloa-Pérez , Marco Carone , Alex Luedtke

Objective: In randomized clinical trials, prediction models can be used to explore the relationships between patients' variables (e.g., clinical, pathological, or lifestyle variables, and also biomarker or genomic data) and treatment effect…

定量方法 · 定量生物学 2026-02-03 Elvire Roblin , Paul-Henry Cournède , Stefan Michiels

Medication recommendation systems are developed to recommend suitable medications tailored to specific patient. Previous researches primarily focus on learning medication representations, which have yielded notable advances. However, these…

人工智能 · 计算机科学 2024-07-23 Xiang Li , Shunpan Liang , Yu Lei , Chen Li , Yulei Hou , Tengfei Ma

Globally, chronic liver disease continues to be a major health concern that requires precise predictive models for prompt detection and treatment. Using the Indian Liver Patient Dataset (ILPD) from the University of California at Irvine's…

机器学习 · 计算机科学 2024-12-31 Anand Karna , Naina Khan , Rahul Rauniyar , Prashant Giridhar Shambharkar