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The opioid crisis represents a significant moment in public health that reveals systemic shortcomings across regulatory systems, healthcare practices, corporate governance, and public policy. Analyzing how these interconnected systems…

Estimating the number of the number of people from hidden and/or marginalised populations - such as people dependent on opioids or cocaine - is important to guide policy decisions and provision of harm reduction services. Methods such as…

Not only does mobile health technology enable researchers to track changes in multiple longitudinal outcomes of interest and to record the occurrence of health-related events over time, but it also allows for the delivery of repeated…

Alcohol Use Disorder (AUD) treatment presents high individual-level heterogeneity, with outcomes ranging from complete abstinence to persistent heavy drinking. This variability-driven by complex behavioral, social, and environmental…

Accurate and explainable health event predictions are becoming crucial for healthcare providers to develop care plans for patients. The availability of electronic health records (EHR) has enabled machine learning advances in providing these…

机器学习 · 计算机科学 2021-05-18 Chang Lu , Chandan K. Reddy , Prithwish Chakraborty , Samantha Kleinberg , Yue Ning

Drug synergy prediction (DSP) aims to identify efficacious drug combinations under various cellular contexts with different targets. However, the continual emergence of novel compounds results in variations in molecular scaffolds and sizes,…

机器学习 · 计算机科学 2026-05-29 Xin Wang , Linxin Xiao , Yang Yao , Wenwu Zhu

Drug repurposing identifies new therapeutic uses for existing drugs, reducing the time and costs compared to traditional de novo drug discovery. Most existing drug repurposing studies using real-world patient data often treat the entire…

机器学习 · 计算机科学 2024-12-31 Seungyeon Lee , Ruoqi Liu , Feixiong Cheng , Ping Zhang

According to the features of drug addiction, this paper constructs an SEIR-based SUC model to describe and predict the spread of drug addiction. Predictions are that the number of drug addictions will continue to fluctuate with reduced…

种群与进化 · 定量生物学 2020-01-22 Boyue Fang , Yutong Feng

Single subject prediction of brain disorders from neuroimaging data has gained increasing attention in recent years. Yet, for some heterogeneous disorders such as major depression disorder (MDD) and autism spectrum disorder (ASD), the…

机器学习 · 计算机科学 2022-06-08 Ahmed El Gazzar , Rajat Mani Thomas , Guido Van Wingen

We compare two multi-state modelling frameworks that can be used to represent dates of events following hospital admission for people infected during an epidemic. The methods are applied to data from people admitted to hospital with…

The open-world test dataset is often mixed with out-of-distribution (OOD) samples, where the deployed models will struggle to make accurate predictions. Traditional detection methods need to trade off OOD detection and in-distribution (ID)…

机器学习 · 计算机科学 2024-04-25 Xu Shen , Yili Wang , Kaixiong Zhou , Shirui Pan , Xin Wang

Drug overdose remains a critical global health issue, often driven by misuse of opioids, painkillers, and psychiatric medications. Traditional research methods face limitations, whereas social media offers real-time insights into…

计算与语言 · 计算机科学 2025-07-16 Muhammad Ahmad , Fida Ullah , Muhammad Usman , Umyh Habiba , ldar Batyrshin , Grigori Sidorov

Opioid and substance misuse is rampant in the United States today, with the phenomenon known as the opioid crisis. The relationship between substance use and mental health has been extensively studied, with one possible relationship being…

Clinical decision-making is a fundamental stage in delivering appropriate care to patients. In recent years several decision-making systems designed to aid the clinician in this process have been developed. However, technical solutions…

计算与语言 · 计算机科学 2023-10-10 Rakhilya Lee Mekhtieva , Brandon Forbes , Dalal Alrajeh , Brendan Delaney , Alessandra Russo

The opioid crisis remains a critical public health challenge in the United States. Despite national efforts which reduced opioid prescribing rates by nearly 45\% between 2011 and 2021, opioid-related overdose deaths more than tripled during…

计算机与社会 · 计算机科学 2025-08-20 Andrew Deas , Adam Spannaus , Dakotah D. Maguire , Jodie Trafton , Anuj J. Kapadia , Vasileios Maroulas

Mental health is an urgent societal issue, and social scientists are increasingly turning to online mental health communities (OMHCs) to analyze user behavior data for early intervention. However, existing sequence mining techniques fall…

人机交互 · 计算机科学 2025-12-04 Rui Sheng , Yifang Wang , Xingbo Wang , Shun Dai , Qingyu Guo , Tai-Quan Peng , Huamin Qu , Dongyu Liu

With the advancement of information technology, more people, especially young adults, are getting addicted to the use of different social media platforms. Despite immense useful applications in communication and interactions, the habit of…

物理与社会 · 物理学 2023-07-20 Dibyajyoti Mallick , Priya Chakraborty , Sayantari Ghosh

Patients resuscitated from cardiac arrest (CA) face a high risk of neurological disability and death, however pragmatic methods are lacking for accurate and reliable prognostication. The aim of this study was to build computational models…

Text-based counseling is an important interface for AI mental-health support, where transcripts may be used to monitor depression severity and flag sessions requiring timely human review. However, robust PHQ-8 prediction across session…

机器学习 · 计算机科学 2026-05-22 Zhaomin Wu , Jiayi Li , Bingsheng He

The escalating drug addiction crisis in the United States underscores the urgent need for innovative therapeutic strategies. This study embarked on an innovative and rigorous strategy to unearth potential drug repurposing candidates for…

生物大分子 · 定量生物学 2023-12-05 Hongyan Du , Guo-Wei Wei , Tingjun Hou