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The use of multi-centric analyses is crucial for obtaining sufficient sample sizes and representative clinical populations in experimental studies. In this setting, data harmonization techniques are typically employed to address systematic…

定量方法 · 定量生物学 2026-01-22 Santiago Silva , Ghiles Reguig , Neil P Oxtoby , Andre Altmann , Marco Lorenzi

Bridging the gap between internal and external validity is crucial for heterogeneous treatment effect estimation. Randomised controlled trials (RCTs), favoured for their internal validity due to randomisation, often encounter challenges in…

统计方法学 · 统计学 2026-04-03 Evangelos Dimitriou , Edwin Fong , Jens Magelund Tarp , Karla Diaz-Ordaz , Brieuc Lehmann

Recent work has focused on the potential and pitfalls of causal identification in observational studies with multiple simultaneous treatments. Building on previous work, we show that even if the conditional distribution of unmeasured…

统计方法学 · 统计学 2025-03-28 Jiajing Zheng , Alexander D'Amour , Alexander Franks

Matching in observational studies faces complications when units enroll in treatment on a rolling basis. While each treated unit has a specific time of entry into the study, control units each have many possible comparison, or…

统计方法学 · 统计学 2024-07-16 Amanda K. Glazer , Samuel D. Pimentel

Adjusting for confounding and imbalance when establishing statistical relationships is an increasingly important task, and causal inference methods have emerged as the most popular tool to achieve this. Causal inference has been developed…

统计方法学 · 统计学 2025-01-20 Daisuke Kurisu , Yidong Zhou , Taisuke Otsu , Hans-Georg Müller

Modern medical research demands specialized causal inference methods evaluating complex continuous-time dynamic treatment regimens using observational data. For instance, obtaining the causal effects of intravenous administration, a…

统计方法学 · 统计学 2026-04-02 Haiyan Zhu , Yingchun Zhou

We introduce OpportunityFinder, a code-less framework for performing a variety of causal inference studies with panel data for non-expert users. In its current state, OpportunityFinder only requires users to provide raw observational data…

机器学习 · 计算机科学 2023-09-26 Huy Nguyen , Prince Grover , Devashish Khatwani

In the absence of randomized controlled and natural experiments, it is necessary to balance the distributions of (observable) covariates of the treated and control groups in order to obtain an unbiased estimate of a causal effect of…

统计方法学 · 统计学 2022-03-02 Martin Cousineau , Vedat Verter , Susan A. Murphy , Joelle Pineau

In this paper we propose a new template for empirical studies intended to assess causal effects: the outcome-wide longitudinal design. The approach is an extension of what is often done to assess the causal effects of a treatment or…

统计方法学 · 统计学 2018-10-25 Tyler J. VanderWeele , Maya B. Mathur , Ying Chen

Causal inference analysis is the estimation of the effects of actions on outcomes. In the context of healthcare data this means estimating the outcome of counter-factual treatments (i.e. including treatments that were not observed) on a…

统计方法学 · 统计学 2018-03-21 Yishai Shimoni , Chen Yanover , Ehud Karavani , Yaara Goldschmnidt

Identification of treatment effects in the presence of unmeasured confounding is a persistent problem in the social, biological, and medical sciences. The problem of unmeasured confounding in settings with multiple treatments is most common…

统计方法学 · 统计学 2022-07-12 Wang Miao , Wenjie Hu , Elizabeth L. Ogburn , Xiaohua Zhou

Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

Causal inference, as a major research area in statistics and data science, plays a central role across diverse fields such as medicine, economics, education, and the social sciences. Design-based causal inference begins with randomized…

统计方法学 · 统计学 2025-12-01 Xin Lu , Wanjia Fu , Hongzi Li , Haoyang Yu , Honghao Zhang , Ke Zhu , Hanzhong Liu

We propose a novel framework for matching estimators for causal effect from observational data that is based on minimizing the dual norm of estimation error when expressed as an operator. We show that many popular matching estimators can be…

统计方法学 · 统计学 2017-03-01 Nathan Kallus

Ascertaining causal direction from observational data is a fundamental challenge in scientific inquiry. Of particular interest is the problem of covariate-adjusted bivariate causal discovery, i.e., determining the causal direction between X…

统计方法学 · 统计学 2025-07-30 Soumik Purkayastha , Peter X. -K. Song

The development of high-throughput sequencing and targeted therapies has led to the emergence of personalized medicine: a patient's molecular profile or the presence of a specific biomarker of drug response will correspond to a treatment…

应用统计 · 统计学 2020-05-27 Jonas Béal , Aurélien Latouche

Valid causal inference in observational studies often requires controlling for confounders. However, in practice measurements of confounders may be noisy, and can lead to biased estimates of causal effects. We show that we can reduce the…

机器学习 · 统计学 2018-06-05 Nathan Kallus , Xiaojie Mao , Madeleine Udell

Estimating treatment effects conditional on observed covariates can improve the ability to tailor treatments to particular individuals. Doing so effectively requires dealing with potential confounding, and also enough data to adequately…

When drawing causal inferences about the effects of multiple treatments on clustered survival outcomes using observational data, we need to address implications of the multilevel data structure, multiple treatments, censoring and unmeasured…

统计方法学 · 统计学 2022-02-18 Liangyuan Hu , Jiayi Ji , Ronald D. Ennis , Joseph W. Hogan

Treatment effect estimation is essential for informed decision-making in many fields such as healthcare, economics, and public policy. While flexible machine learning models have been widely applied for estimating heterogeneous treatment…

机器学习 · 计算机科学 2025-09-29 Pascal Memmesheimer , Vincent Heuveline , Jürgen Hesser