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Individualized treatment effect lies at the heart of precision medicine. Interpretable individualized treatment rules (ITRs) are desirable for clinicians or policymakers due to their intuitive appeal and transparency. The gold-standard…

统计方法学 · 统计学 2021-08-20 Lili Wu , Shu Yang

Individualized treatment rules (ITRs) for treatment recommendation is an important topic for precision medicine as not all beneficial treatments work well for all individuals. Interpretability is a desirable property of ITRs, as it helps…

统计方法学 · 统计学 2023-11-06 Jacob M. Maronge , Jared D. Huling , Guanhua Chen

Learning individualized treatment rules (ITRs) is an important topic in precision medicine. Current literature mainly focuses on deriving ITRs from a single source population. We consider the observational data setting when the source…

机器学习 · 统计学 2023-07-04 Rui Chen , Jared D. Huling , Guanhua Chen , Menggang Yu

An individualized treatment regime (ITR) is a decision rule that assigns treatments based on patients' characteristics. The value function of an ITR is the expected outcome in a counterfactual world had this ITR been implemented. Recently,…

统计方法学 · 统计学 2023-01-16 Pan Zhao , Julie Josse , Shu Yang

Randomized controlled trials typically analyze the effectiveness of treatments with the goal of making treatment recommendations for patient subgroups. With the advance of electronic health records, a great variety of data has been…

机器学习 · 计算机科学 2021-03-31 Zhiliang Wu , Yinchong Yang , Yunpu Ma , Yushan Liu , Rui Zhao , Michael Moor , Volker Tresp

Modern precision medicine aims to utilize real-world data to provide the best treatment for an individual patient. An individualized treatment rule (ITR) maps each patient's characteristics to a recommended treatment scheme that maximizes…

应用统计 · 统计学 2025-01-07 Andong Wang , Kelly Wentzlof , Johnny Rajala , Miontranese Green , Yunshu Zhang , Shu Yang

The objective of this work is to improve the accuracy of building demand forecasting. This is a more challenging task than grid level forecasting. For the said purpose, we develop a new technique called recurrent transform learning (RTL).…

机器学习 · 计算机科学 2019-12-12 Megha Gupta , Angshul Majumdar

We propose a novel adaptive transfer learning framework, learning to transfer learn (L2TL), to improve performance on a target dataset by careful extraction of the related information from a source dataset. Our framework considers…

机器学习 · 计算机科学 2020-07-17 Linchao Zhu , Sercan O. Arik , Yi Yang , Tomas Pfister

An individualized treatment rule (ITR) tailors treatments to a patient's specific characteristics. However, randomized controlled trials (RCTs) are often underpowered to detect the treatment effect heterogeneity needed for reliable ITR…

统计方法学 · 统计学 2026-04-14 Yuan Bian , Donglin Zeng , Hyun-Joon Yang , Leanne M. Williams , Yuanjia Wang

To promote precision medicine, individualized treatment regimes (ITRs) are crucial for optimizing the expected clinical outcome based on patient-specific characteristics. However, existing ITR research has primarily focused on scenarios…

统计方法学 · 统计学 2024-02-20 Chang Wang , Lu Wang

Personalized medicine has received increasing attention among statisticians, computer scientists, and clinical practitioners. A major component of personalized medicine is the estimation of individualized treatment rules (ITRs). Recently,…

统计方法学 · 统计学 2015-08-14 Xin Zhou , Nicole Mayer-Hamblett , Umer Khan , Michael R. Kosorok

Individualized treatment rules (ITRs) aim to optimize healthcare by tailoring treatment decisions to patient-specific characteristics. Existing methods typically rely on either interpretable but inflexible models or highly flexible…

统计方法学 · 统计学 2026-02-13 Yasin Khadem Charvadeh , Katherine S. Panageas , Yuan Chen

Integrative analysis of multiple datasets for estimating optimal individualized treatment rules (ITRs) can enhance decision efficiency. A central challenge is posterior shift, wherein the conditional distribution of potential outcomes given…

机器学习 · 统计学 2026-03-09 Wenhai Cui , Wen Su , Xingqiu Zhao

Many medical datasets have recently been created for medical image segmentation tasks, and it is natural to question whether we can use them to sequentially train a single model that (1) performs better on all these datasets, and (2)…

计算机视觉与模式识别 · 计算机科学 2022-08-02 Chenyu You , Jinlin Xiang , Kun Su , Xiaoran Zhang , Siyuan Dong , John Onofrey , Lawrence Staib , James S. Duncan

Recently, large language models (LLMs) have demonstrated excellent performance, inspiring researchers to explore their use in automating register transfer level (RTL) code generation and improving hardware design efficiency. However, the…

计算与语言 · 计算机科学 2025-04-24 Peiyang Wu , Nan Guo , Xiao Xiao , Wenming Li , Xiaochun Ye , Dongrui Fan

Medical treatments tailored to a patient's baseline characteristics hold the potential of improving patient outcomes while reducing negative side effects. Learning individualized treatment rules (ITRs) often requires aggregation of multiple…

机器学习 · 统计学 2022-12-15 Jay Jojo Cheng , Jared D. Huling , Guanhua Chen

Individualized treatment recommendation (ITR) is an important analytic framework for precision medicine. The goal is to assign proper treatments to patients based on their individual characteristics. From the machine learning perspective,…

机器学习 · 统计学 2020-04-07 Haomiao Meng , Ying-Qi Zhao , Haoda Fu , Xingye Qiao

Deep text matching approaches have been widely studied for many applications including question answering and information retrieval systems. To deal with a domain that has insufficient labeled data, these approaches can be used in a…

信息检索 · 计算机科学 2019-01-01 Chen Qu , Feng Ji , Minghui Qiu , Liu Yang , Zhiyu Min , Haiqing Chen , Jun Huang , W. Bruce Croft

An individualized treatment rule (ITR) is a decision rule that aims to improve individual patients health outcomes by recommending optimal treatments according to patients specific information. In observational studies, collected data may…

统计方法学 · 统计学 2023-10-03 Zeyu Bian , Erica EM Moodie , Susan M Shortreed , Sylvie D Lambert , Sahir Bhatnagar

We consider Heterogeneous Transfer Learning (HTL) from a source to a new target domain for high-dimensional regression with differing feature sets. Most homogeneous TL methods assume that target and source domains share the same feature…

机器学习 · 统计学 2025-12-02 Jae Ho Chang , Massimiliano Russo , Subhadeep Paul
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