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Variational Autoencoders (VAEs) typically rely on a probabilistic decoder with a predefined likelihood, most commonly an isotropic Gaussian, to model the data conditional on latent variables. While convenient for optimization, this choice…

机器学习 · 统计学 2025-04-29 Chen Xu , Qiang Wang , Lijun Sun

In the following short article we adapt a new and popular machine learning model for inference on medical data sets. Our method is based on the Variational AutoEncoder (VAE) framework that we adapt to survival analysis on small data sets…

机器学习 · 统计学 2018-12-06 Cédric Beaulac , Jeffrey S. Rosenthal , David Hodgson

A key advance in learning generative models is the use of amortized inference distributions that are jointly trained with the models. We find that existing training objectives for variational autoencoders can lead to inaccurate amortized…

机器学习 · 计算机科学 2018-05-31 Shengjia Zhao , Jiaming Song , Stefano Ermon

Understanding the structure of complex, nonstationary, high-dimensional time-evolving signals is a central challenge in scientific data analysis. In many domains, such as speech and biomedical signal processing, the ability to learn…

机器学习 · 计算机科学 2026-01-13 Ioannis Ziogas , Aamna Al Shehhi , Ahsan H. Khandoker , Leontios J. Hadjileontiadis

Chemical abundance determinations from stellar spectra are challenged by observational noise, limitations in stellar models, and departures from simplifying assumptions. While traditional and supervised machine learning methods have made…

太阳与恒星天体物理 · 物理学 2025-12-24 Theosamuele Signor , Paula Jofré , Hernan Lira , Sara Vitali , Luis Martí , Nayat Sánchez-Pi

We propose a topic-guided variational autoencoder (TGVAE) model for text generation. Distinct from existing variational autoencoder (VAE) based approaches, which assume a simple Gaussian prior for the latent code, our model specifies the…

计算与语言 · 计算机科学 2019-03-19 Wenlin Wang , Zhe Gan , Hongteng Xu , Ruiyi Zhang , Guoyin Wang , Dinghan Shen , Changyou Chen , Lawrence Carin

Variational autoencoders (VAE) encode data into lower-dimensional latent vectors before decoding those vectors back to data. Once trained, one can hope to detect out-of-distribution (abnormal) latent vectors, but several issues arise when…

机器学习 · 计算机科学 2026-05-12 Alejandro Ascarate , Leo Lebrat , Rodrigo Santa Cruz , Clinton Fookes , Olivier Salvado

We propose a new class of physics-informed neural networks, called physics-informed Variational Autoencoder (PI-VAE), to solve stochastic differential equations (SDEs) or inverse problems involving SDEs. In these problems the governing…

机器学习 · 统计学 2022-11-09 Weiheng Zhong , Hadi Meidani

Recent advances in neural-based generative modeling have reignited the hopes of having computer systems capable of conversing with humans and able to understand natural language. The employment of deep neural architectures has been largely…

计算与语言 · 计算机科学 2022-11-16 Haoqin Tu , Yitong Li

The ability to record activities from hundreds of neurons simultaneously in the brain has placed an increasing demand for developing appropriate statistical techniques to analyze such data. Recently, deep generative models have been…

机器学习 · 统计学 2020-11-11 Ding Zhou , Xue-Xin Wei

Variational autoencoder (VAE) is a popular method for drug discovery and there had been a great deal of architectures and pipelines proposed to improve its performance. But the VAE model itself suffers from deficiencies such as poor…

机器学习 · 计算机科学 2022-12-07 Chenghui Zhou , Barnabas Poczos

A specific challenge with deep learning approaches for molecule generation is generating both syntactically valid and chemically plausible molecular string representations. To address this, we propose a novel generative latent-variable…

生物大分子 · 定量生物学 2024-07-22 Ulrich A. Mbou Sob , Qiulin Li , Miguel Arbesú , Oliver Bent , Andries P. Smit , Arnu Pretorius

We propose a framework called HyperVAE for encoding distributions of distributions. When a target distribution is modeled by a VAE, its neural network parameters \theta is drawn from a distribution p(\theta) which is modeled by a…

机器学习 · 统计学 2022-05-16 Phuoc Nguyen , Truyen Tran , Sunil Gupta , Santu Rana , Hieu-Chi Dam , Svetha Venkatesh

Visual generative models (e.g., diffusion models) typically operate in compressed latent spaces to balance training efficiency and sample quality. In parallel, there has been growing interest in leveraging high-quality pre-trained visual…

计算机视觉与模式识别 · 计算机科学 2025-12-17 Yuan Gao , Chen Chen , Tianrong Chen , Jiatao Gu

High-throughput phenotypic screens generate vast microscopy image datasets that push the limits of generative models due to their large dimensionality. Despite the growing popularity of general-purpose models trained on natural images for…

定量方法 · 定量生物学 2025-10-24 Télio Cropsal , Rocío Mercado

The de novo generation of molecules with desirable properties is a critical challenge, where diffusion models are computationally intensive and autoregressive models struggle with error propagation. In this work, we introduce the Graph…

机器学习 · 计算机科学 2025-12-03 Haozhuo Zheng , Cheng Wang , Yang Liu

[Abridged] The physical conditions in stellar atmospheres can be obtained from the interpretation of solar spectro-polarimetric observations. However, traditional inversion codes are computationally demanding, especially for lines whose…

天体物理仪器与方法 · 物理学 2025-11-05 A. Asensio Ramos , J. de la Cruz Rodriguez

Time series data is ubiquitous, with forecasting applications spanning from finance to healthcare. Beyond popular deterministic methods, generative models are gaining attention due to advancements in areas like image synthesis and video…

机器学习 · 计算机科学 2025-12-01 Jiawen Wei , Lan Jiang , Pengbo Wei , Ziwen Ye , Teng Song , Chen Chen , Guangrui Ma

Variational Autoencoders (VAEs) are well-established as a principled approach to probabilistic unsupervised learning with neural networks. Typically, an encoder network defines the parameters of a Gaussian distributed latent space from…

机器学习 · 计算机科学 2025-05-16 Alan Jeffares , Liyuan Liu

Latent variable models like the Variational Auto-Encoder (VAE) are commonly used to learn representations of images. However, for downstream tasks like semantic classification, the representations learned by VAE are less competitive than…

机器学习 · 统计学 2022-05-31 Mingtian Zhang , Tim Z. Xiao , Brooks Paige , David Barber