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Single-cell perturbation prediction aims to infer how cells respond to unseen interventions and to achieve out-of-distribution (OOD) generalization, providing a computational route to understanding how perturbations reshape cellular…

机器学习 · 计算机科学 2026-05-26 Wenkang Jiang , Yuhang Liu , Erdun Gao , Ehsan Abbasnejad , Lina Yao , Javen Qinfeng Shi

Approximating distributions over complicated manifolds, such as natural images, are conceptually attractive. The deep latent variable model, trained using variational autoencoders and generative adversarial networks, is now a key technique…

计算机视觉与模式识别 · 计算机科学 2019-10-08 Wenju Xu , Shawn Keshmiri , Guanghui Wang

This paper presents an emotion-regularized conditional variational autoencoder (Emo-CVAE) model for generating emotional conversation responses. In conventional CVAE-based emotional response generation, emotion labels are simply used as…

计算与语言 · 计算机科学 2021-04-20 Yu-Ping Ruan , Zhen-Hua Ling

Recent advances have shown that GP priors, or their finite realisations, can be encoded using deep generative models such as variational autoencoders (VAEs). These learned generators can serve as drop-in replacements for the original priors…

Variational autoencoders (VAEs) have been used extensively to discover low-dimensional latent factors governing neural activity and animal behavior. However, without careful model selection, the uncovered latent factors may reflect noise in…

机器学习 · 计算机科学 2023-12-13 Julia Huiming Wang , Dexter Tsin , Tatiana Engel

Without knowledge of specific pockets, generating ligands based on the global structure of a protein target plays a crucial role in drug discovery as it helps reduce the search space for potential drug-like candidates in the pipeline.…

生物大分子 · 定量生物学 2023-10-02 Nhat Khang Ngo , Truong Son Hy

Generative models in molecular design tend to be richly parameterized, data-hungry neural models, as they must create complex structured objects as outputs. Estimating such models from data may be challenging due to the lack of sufficient…

机器学习 · 计算机科学 2021-08-17 Kevin Yang , Wengong Jin , Kyle Swanson , Regina Barzilay , Tommi Jaakkola

Optimal computations under uncertainty require an adequate probabilistic representation about beliefs. Deep generative models, and specifically Variational Autoencoders (VAEs), have the potential to meet this demand by building latent…

While the beta-VAE family is aiming to find disentangled representations and acquire human-interpretable generative factors, like what an ICA (from the linear domain) does, we propose Full Encoder, a novel unified autoencoder framework as a…

机器学习 · 计算机科学 2021-07-14 Zhouzheng Li , Kun Feng

Generative models based on generative adversarial networks (GANs) and variational autoencoders (VAEs) have been widely studied in the fields of image generation, speech generation, and drug discovery, but, only a few studies have focused on…

机器学习 · 计算机科学 2019-10-28 Yoshihide Sawada , Koji Morikawa , Mikiya Fujii

To act and plan in complex environments, we posit that agents should have a mental simulator of the world with three characteristics: (a) it should build an abstract state representing the condition of the world; (b) it should form a belief…

机器学习 · 计算机科学 2019-01-03 Karol Gregor , George Papamakarios , Frederic Besse , Lars Buesing , Theophane Weber

In recent years, deep generative models have been successfully adopted for various molecular design tasks, particularly in the life and material sciences. A critical challenge for pre-trained generative molecular design (GMD) models is to…

机器学习 · 计算机科学 2024-06-03 A N M Nafiz Abeer , Sanket Jantre , Nathan M Urban , Byung-Jun Yoon

Accurately quantifying uncertainty in predictions and projections arising from irreducible internal climate variability is critical for informed decision making. Such uncertainty is typically assessed using ensembles produced with physics…

机器学习 · 计算机科学 2026-02-09 Parsa Gooya , Reinel Sospedra-Alfonso , Johannes Exenberger

We present a novel unified framework that concurrently tackles recognition and future prediction for human hand pose and action modeling. Previous works generally provide isolated solutions for either recognition or prediction, which not…

计算机视觉与模式识别 · 计算机科学 2024-09-10 Yilin Wen , Hao Pan , Takehiko Ohkawa , Lei Yang , Jia Pan , Yoichi Sato , Taku Komura , Wenping Wang

The Variational Autoencoder (VAE) is a powerful deep generative model that is now extensively used to represent high-dimensional complex data via a low-dimensional latent space learned in an unsupervised manner. In the original VAE model,…

声音 · 计算机科学 2021-06-15 Xiaoyu Bie , Laurent Girin , Simon Leglaive , Thomas Hueber , Xavier Alameda-Pineda

Variational autoencoders (VAEs) employ Bayesian inference to interpret sensory inputs, mirroring processes that occur in primate vision across both ventral (Higgins et al., 2021) and dorsal (Vafaii et al., 2023) pathways. Despite their…

机器学习 · 计算机科学 2024-12-10 Hadi Vafaii , Dekel Galor , Jacob L. Yates

Variational Auto-Encoder (VAE) has become the de-facto learning paradigm in achieving representation learning and generation for natural language at the same time. Nevertheless, existing VAE-based language models either employ elementary…

计算与语言 · 计算机科学 2022-11-22 Haoqin Tu , Zhongliang Yang , Jinshuai Yang , Yongfeng Huang

Deep generative models have been widely used for their ability to generate realistic data samples in various areas, such as images, molecules, text, and speech. One major goal of data generation is controllability, namely to generate new…

机器学习 · 计算机科学 2023-10-12 Bo Pan , Muran Qin , Shiyu Wang , Yifei Zhang , Liang Zhao

Variational auto-encoders (VAEs) are deep generative latent variable models that can be used for learning the distribution of complex data. VAEs have been successfully used to learn a probabilistic prior over speech signals, which is then…

声音 · 计算机科学 2020-12-18 Mostafa Sadeghi , Simon Leglaive , Xavier Alameda-PIneda , Laurent Girin , Radu Horaud

Recently, audio-visual speech enhancement has been tackled in the unsupervised settings based on variational auto-encoders (VAEs), where during training only clean data is used to train a generative model for speech, which at test time is…

音频与语音处理 · 电气工程与系统科学 2021-02-09 Mostafa Sadeghi , Xavier Alameda-Pineda