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One of the main goals of developmental biology is to reveal the gene regulatory networks (GRNs) underlying the robust differentiation of multipotent progenitors into precisely specified cell types. Most existing methods to infer GRNs from…

定量方法 · 定量生物学 2024-01-23 Maria Mircea , Diego Garlaschelli , Stefan Semrau

Biologically-informed neural networks (BINNs), an extension of physics-informed neural networks [1], are introduced and used to discover the underlying dynamics of biological systems from sparse experimental data. In the present work, BINNs…

定量方法 · 定量生物学 2021-01-27 John H. Lagergren , John T. Nardini , Ruth E. Baker , Matthew J. Simpson , Kevin B. Flores

Physics-informed neural networks (PINNs) provide a powerful framework for learning governing equations of dynamical systems from data. Biologically-informed neural networks (BINNs) are a variant of PINNs that preserve the known differential…

机器学习 · 计算机科学 2026-04-21 William Lavery , Jodie A. Cochrane , Christian Olesen , Dagim S. Tadele , John T. Nardini , Sara Hamis

The increasing availability of large-scale observational data and the rapid development of artificial intelligence (AI) provide unprecedented opportunities to enhance our understanding of the global carbon cycle and other biogeochemical…

We introduce the concept of a Graph-Informed Neural Network (GINN), a hybrid approach combining deep learning with probabilistic graphical models (PGMs) that acts as a surrogate for physics-based representations of multiscale and…

计算物理 · 物理学 2021-03-17 Eric J. Hall , Søren Taverniers , Markos A. Katsoulakis , Daniel M. Tartakovsky

Physically informed neural networks (PINNs) are a promising emerging method for solving differential equations. As in many other deep learning approaches, the choice of PINN design and training protocol requires careful craftsmanship. Here,…

机器学习 · 统计学 2023-10-09 Inbar Seroussi , Asaf Miron , Zohar Ringel

Physics-informed neural networks (PINNs) are neural networks that embed the laws of dynamical systems modeled by differential equations into their loss function as constraints. In this work, we present a PINN framework applied to oncology.…

机器学习 · 计算机科学 2025-10-16 Kayode Olumoyin , Katarzyna Rejniak

Neural network models have shown outstanding performance and successful resolutions to complex problems in various fields. However, the majority of these models are viewed as black-box, requiring a significant amount of data for…

机器学习 · 计算机科学 2024-04-04 Wanli Xie , Ruibin Zhao , Zhenguo Xu , Tingting Liang

We develop improved physics-informed neural networks (PINNs) for high-order and high-dimensional power system models described by nonlinear ordinary differential equations. We propose some novel enhancements to improve PINN training and…

机器学习 · 计算机科学 2024-10-11 Vineet Jagadeesan Nair

Graph neural networks (GNNs) have shown significant success in learning graph representations. However, recent studies reveal that GNNs often fail to outperform simple MLPs on heterophilous graph tasks, where connected nodes may differ in…

机器学习 · 计算机科学 2025-04-10 Songwei Zhao , Yuan Jiang , Zijing Zhang , Yang Yu , Hechang Chen

In this paper, we make the first attempt to apply the boundary integrated neural networks (BINNs) for the numerical solution of two-dimensional (2D) elastostatic and piezoelectric problems. BINNs combine artificial neural networks with the…

计算工程、金融与科学 · 计算机科学 2023-08-03 Peijun Zhang , Chuanzeng Zhang , Yan Gu , Wenzhen Qu , Shengdong Zhao

We propose characteristics-informed neural networks (CINN), a simple and efficient machine learning approach for solving forward and inverse problems involving hyperbolic PDEs. Like physics-informed neural networks (PINN), CINN is a…

机器学习 · 计算机科学 2023-01-16 Ulisses Braga-Neto

Physics-informed neural networks (PINNs) are at the forefront of scientific machine learning, making possible the creation of machine intelligence that is cognizant of physical laws and able to accurately simulate them. However, today's…

神经与进化计算 · 计算机科学 2026-02-23 Jian Cheng Wong , Chin Chun Ooi , Abhishek Gupta , Pao-Hsiung Chiu , Joshua Shao Zheng Low , My Ha Dao , Yew-Soon Ong

Collective migration is an important component of many biological processes, including wound healing, tumorigenesis, and embryo development. Spatial agent-based models (ABMs) are often used to model collective migration, but it is…

定量方法 · 定量生物学 2026-03-11 John T. Nardini

Geometry is a ubiquitous tool in computer graphics, design, and engineering. However, the lack of large shape datasets limits the application of state-of-the-art supervised learning methods and motivates the exploration of alternative…

Hypergraph neural networks can model multi-way connections among nodes of the graphs, which are common in real-world applications such as genetic medicine. In particular, genetic pathways or gene sets encode molecular functions driven by…

机器学习 · 计算机科学 2022-10-17 Yuan Luo

Physics-Informed Neural Network (PINN) has proven itself a powerful tool to obtain the numerical solutions of nonlinear partial differential equations (PDEs) leveraging the expressivity of deep neural networks and the computing power of…

数值分析 · 数学 2023-06-12 Yanlai Chen , Shawn Koohy

Nonconvex multi-well energies in cell-induced phase transitions give rise to fine-scale microstructures, low-regularity transition layers and sharp interfaces, all of which pose numerical challenges for physics-informed learning. Here we…

机器学习 · 计算机科学 2026-05-05 Anci Lin , Zhiwen Zhang , Wenju Zhao

Deep learning models trained on finite data lack a complete understanding of the physical world. On the other hand, physics-informed neural networks (PINNs) are infused with such knowledge through the incorporation of mathematically…

神经与进化计算 · 计算机科学 2026-02-23 Jian Cheng Wong , Abhishek Gupta , Chin Chun Ooi , Pao-Hsiung Chiu , Jiao Liu , Yew-Soon Ong

Physics-informed neural networks (PINNs), rooted in deep learning, have emerged as a promising approach for solving partial differential equations (PDEs). By embedding the physical information described by PDEs into feedforward neural…

机器学习 · 计算机科学 2024-01-26 Yanzhi Liu , Ruifan Wu , Ying Jiang
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