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Identifying variables associated with clinical endpoints is of much interest in clinical trials. With the rapid growth of cell and gene therapy (CGT) and therapeutics for ultra-rare diseases, there is an urgent need for statistical methods…

统计方法学 · 统计学 2025-11-18 Lingxuan Kong , Yumin Zhang , Chenkun Wang , Yaoyuan Vincent Tan

Computational antibody design seeks to automatically create an antibody that binds to an antigen. The binding affinity is governed by the 3D binding interface where antibody residues (paratope) closely interact with antigen residues…

生物大分子 · 定量生物学 2022-07-15 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Recently Transformer has shown good performance in several vision tasks due to its powerful modeling capabilities. To reduce the quadratic complexity caused by the attention, some outstanding work restricts attention to local regions or…

计算机视觉与模式识别 · 计算机科学 2023-05-03 Fangjian Lin , Yizhe Ma , Sitong Wu , Long Yu , Shengwei Tian

AlphaFold 3 (AF3) is a powerful biomolecular structure-predicting tool based on the latest deep learning algorithms and revolutionized AI model architectures. A few of papers have already investigated its accuracy in predicting different…

生物大分子 · 定量生物学 2025-11-19 Yiyang Xu , Ziyou Shen , Yanqing Lv , Shutong Tan , Chun Sun , Juan Zhang

Network embedding represents nodes in a continuous vector space and preserves structure information from the Network. Existing methods usually adopt a "one-size-fits-all" approach when concerning multi-scale structure information, such as…

机器学习 · 计算机科学 2018-03-28 Lei Sang , Min Xu , Shengsheng Qian , Xindong Wu

Accurate beam prediction is essential for maintaining reliable links and high spectral efficiency in dynamic low-altitude wireless networks. However, existing approaches often fail to capture the deep correlations across heterogeneous…

信号处理 · 电气工程与系统科学 2025-12-03 Xiaotong Zhao , Yuanhao Cui , Weijie Yuan , Ziye Jia , Heng Liu , Chengwen Xing

Graph convolutional networks (GCNs) have been widely used and achieved remarkable results in skeleton-based action recognition. We think the key to skeleton-based action recognition is a skeleton hanging in frames, so we focus on how the…

计算机视觉与模式识别 · 计算机科学 2023-12-07 Nguyen Huu Bao Long

Accurate prediction of antibody-antigen binding affinity is fundamental to therapeutic design, yet remains constrained by severe label sparsity and the complexity of antigenic variations. In this paper, we propose AbLWR (Antibody-antigen…

机器学习 · 计算机科学 2026-04-14 Fan Xu , Zhi-an Huang , Haohuai He , Yidong Song , Wei Liu , Dongxu Zhang , Yao Hu , Kay Chen Tan

Medical image segmentation, a crucial task in computer vision, facilitates the automated delineation of anatomical structures and pathologies, supporting clinicians in diagnosis, treatment planning, and disease monitoring. Notably,…

计算机视觉与模式识别 · 计算机科学 2024-12-11 Fuchen Zheng , Xinyi Chen , Xuhang Chen , Haolun Li , Xiaojiao Guo , Weihuang Liu , Chi-Man Pun , Shoujun Zhou

We consider the problem of antibody sequence design given 3D structural information. Building on previous work, we propose a fine-tuned inverse folding model that is specifically optimised for antibody structures and outperforms generic…

生物大分子 · 定量生物学 2023-10-31 Frédéric A. Dreyer , Daniel Cutting , Constantin Schneider , Henry Kenlay , Charlotte M. Deane

At present, people usually use some methods based on convolutional neural networks (CNNs) for Electroencephalograph (EEG) decoding. However, CNNs have limitations in perceiving global dependencies, which is not adequate for common EEG…

信号处理 · 电气工程与系统科学 2021-06-23 Yonghao Song , Xueyu Jia , Lie Yang , Longhan Xie

The task of 2D human pose estimation is challenging as the number of keypoints is typically large (~ 17) and this necessitates the use of robust neural network architectures and training pipelines that can capture the relevant features from…

机器学习 · 计算机科学 2022-04-22 Kaushik Balakrishnan , Devesh Upadhyay

Recent stereo matching networks achieves dramatic performance by introducing epipolar line constraint to limit the matching range of dual-view. However, in complicated real-world scenarios, the feature information based on intra-epipolar…

计算机视觉与模式识别 · 计算机科学 2023-08-08 Wei Miao , Hong Zhao , Tongjia Chen , Wei Huang , Changyan Xiao

While the performance of face recognition systems has improved significantly in the last decade, they are proved to be highly vulnerable to presentation attacks (spoofing). Most of the research in the field of face presentation attack…

计算机视觉与模式识别 · 计算机科学 2019-07-10 Olegs Nikisins , Anjith George , Sebastien Marcel

While conventional computer vision emphasizes pixel-level and feature-based objectives, medical image analysis of intricate biological structures necessitates explicit representation of their complex topological properties. Despite their…

图像与视频处理 · 电气工程与系统科学 2024-12-31 Yousef Yeganeh , Rui Xiao , Goktug Guvercin , Nassir Navab , Azade Farshad

We propose Axial Transformers, a self-attention-based autoregressive model for images and other data organized as high dimensional tensors. Existing autoregressive models either suffer from excessively large computational resource…

计算机视觉与模式识别 · 计算机科学 2019-12-30 Jonathan Ho , Nal Kalchbrenner , Dirk Weissenborn , Tim Salimans

Accurate traffic forecasting is essential for intelligent transportation systems, supporting a wide range of real-world applications. However, it remains challenging due to two key factors:~(1) Traffic series contain heterogeneous temporal…

人工智能 · 计算机科学 2026-05-26 Ruiwen Gu , Qitai Tan , Yahao Liu , Xiao-Ping Zhang

Many factors influence biomolecules binding, and its assessment constitutes an elusive challenge in computational structural biology. In this respect, the evaluation of shape complementarity at molecular interfaces is one of the main…

Antibody-based therapeutics-including antibody-drug conjugates (ADCs), bispecific antibodies, and novel formats-are reshaping oncology, yet key determinants of efficacy, safety, and manufacturability frequently emerge after conjugation and…

软凝聚态物质 · 物理学 2026-05-18 Alberto Ocana , Jorge R. Espinosa

Anomaly detection (AD) plays a vital role across a wide range of domains, but its performance might deteriorate when applied to target domains with limited data. Domain Adaptation (DA) offers a solution by transferring knowledge from a…

机器学习 · 统计学 2025-08-12 Tran Tuan Kiet , Nguyen Thang Loi , Vo Nguyen Le Duy