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Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a…

This paper introduces a novel Large Language Models (LLMs)-assisted agent that automatically converts natural-language descriptions of power system optimization scenarios into compact, solver-ready formulations and generates corresponding…

人工智能 · 计算机科学 2025-08-12 Yunkai Hu , Tianqiao Zhao , Meng Yue

Personalised medicine strives to identify the right treatment for the right patient at the right time, integrating different types of biological and environmental information. Such information come from a variety of sources: omics data…

应用统计 · 统计学 2014-01-14 Marco Scutari

To ensure the trustworthiness and interpretability of AI systems, it is essential to align machine learning models with human domain knowledge. This can be a challenging and time-consuming endeavor that requires close communication between…

机器学习 · 计算机科学 2025-04-01 Alexander Koebler , Ingo Thon , Florian Buettner

Automated clinical text anonymization has the potential to unlock the widespread sharing of textual health data for secondary usage while assuring patient privacy and safety. Despite the proposal of many complex and theoretically successful…

Tool learning has emerged as a promising direction by extending Large Language Models' (LLMs) capabilities with external tools. Existing tool learning studies primarily focus on the general-purpose tool-use capability, which addresses…

计算与语言 · 计算机科学 2025-02-27 Qiancheng Xu , Yongqi Li , Heming Xia , Fan Liu , Min Yang , Wenjie Li

Fine-tuning Large Language Models (LLMs) incurs considerable training costs, driving the need for data-efficient training with optimised data ordering. Human-inspired strategies offer a solution by organising data based on human learning…

计算与语言 · 计算机科学 2024-11-06 Yushi Yang , Andrew M. Bean , Robert McCraith , Adam Mahdi

Analyzing vast textual data and summarizing key information from electronic health records imposes a substantial burden on how clinicians allocate their time. Although large language models (LLMs) have shown promise in natural language…

Europe's healthcare systems require enhanced interoperability and digitalization, driving a demand for innovative solutions to process legacy clinical data. This paper presents the results of our project, which aims to leverage Large…

计算与语言 · 计算机科学 2025-07-09 Aynur Guluzade , Naguib Heiba , Zeyd Boukhers , Florim Hamiti , Jahid Hasan Polash , Yehya Mohamad , Carlos A Velasco

The integration of Large Language Models (LLMs) into healthcare holds significant potential to enhance diagnostic accuracy and support medical treatment planning. These AI-driven systems can analyze vast datasets, assisting clinicians in…

计算与语言 · 计算机科学 2025-04-15 Diogo Sousa , Guilherme Barbosa , Catarina Rocha , Dulce Oliveira

This project investigates the efficacy of Large Language Models (LLMs) in understanding and extracting scientific knowledge across specific domains and to create a deep learning framework: Knowledge AI. As a part of this framework, we…

计算与语言 · 计算机科学 2024-08-12 Balaji Muralidharan , Hayden Beadles , Reza Marzban , Kalyan Sashank Mupparaju

Existing domain-specific Large Language Models (LLMs) are typically developed by fine-tuning general-purposed LLMs with large-scale domain-specific corpora. However, training on large-scale corpora often fails to effectively organize domain…

计算与语言 · 计算机科学 2025-02-11 Zhiqiang Liu , Chengtao Gan , Junjie Wang , Yichi Zhang , Zhongpu Bo , Mengshu Sun , Huajun Chen , Wen Zhang

Machine reasoning has made great progress in recent years owing to large language models (LLMs). In the clinical domain, however, most NLP-driven projects mainly focus on clinical classification or reading comprehension, and under-explore…

Large language model (LLM) personalization aims to align model outputs with individuals' unique preferences and opinions. While recent efforts have implemented various personalization methods, a unified theoretical framework that can…

计算与语言 · 计算机科学 2025-09-30 Xinliang Frederick Zhang , Nick Beauchamp , Lu Wang

Large Language Model (LLM)-based agents have demonstrated strong capabilities across a wide range of tasks, and their application in the medical domain holds particular promise due to the demand for high generalizability and reliance on…

人工智能 · 计算机科学 2025-08-18 Yangyang Zhuang , Wenjia Jiang , Jiayu Zhang , Ze Yang , Joey Tianyi Zhou , Chi Zhang

Recommender systems are widely used in online services, with embedding-based models being particularly popular due to their expressiveness in representing complex signals. However, these models often function as a black box, making them…

信息检索 · 计算机科学 2024-06-25 Yuxuan Lei , Jianxun Lian , Jing Yao , Xu Huang , Defu Lian , Xing Xie

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

人工智能 · 计算机科学 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

计算机与社会 · 计算机科学 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

Clinical patient notes are critical for documenting patient interactions, diagnoses, and treatment plans in medical practice. Ensuring accurate evaluation of these notes is essential for medical education and certification. However, manual…

计算与语言 · 计算机科学 2024-01-25 Jingyu Xu , Yifeng Jiang , Bin Yuan , Shulin Li , Tianbo Song

Large language models (LLMs) hold promise for transforming healthcare, from streamlining administrative and clinical workflows to enriching patient engagement and advancing clinical decision-making. However, their successful integration…

计算机与社会 · 计算机科学 2025-04-04 Mohammed Al-Garadi , Tushar Mungle , Abdulaziz Ahmed , Abeed Sarker , Zhuqi Miao , Michael E. Matheny