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Target Safety Assessment (TSA) requires systematic integration of heterogeneous evidence, including genetic, transcriptomic, target homology, pharmacological, and clinical data, to evaluate potential safety liabilities of therapeutic…

计算与语言 · 计算机科学 2026-05-11 Xiaochen Zheng , Zhiwen Jiang , Melanie Guerard , Klas Hatje , Tatyana Doktorova

Simulation is essential to validate autonomous driving systems. However, a simple simulation, even for an extremely high number of simulated miles or hours, is not sufficient. We need well-founded criteria showing that simulation does…

软件工程 · 计算机科学 2023-01-24 Changwen Li , Joseph Sifakis , Qiang Wang , Rongjie Yan , Jian Zhang

The capability to follow a lead-vehicle and avoid rear-end collisions is one of the most important functionalities for human drivers and various Advanced Driver Assist Systems (ADAS). Existing safety performance justification of the…

机器人学 · 计算机科学 2022-05-25 Bowen Weng , Minghao Zhu , Keith Redmill

When AI systems are granted the agency to take impactful actions in the real world, there is an inherent risk that these systems behave in ways that are harmful. Typically, humans specify constraints on the AI system to prevent harmful…

人机交互 · 计算机科学 2022-11-09 Travis Mandel , Jahnu Best , Randall H. Tanaka , Hiram Temple , Chansen Haili , Kayla Schlectinger , Roy Szeto

Safety filters in commercial text-to-image (T2I) models systematically block legitimate artistic content involving the human figure, treating classical nude photography with the same restrictiveness as explicit material. While prior…

多媒体 · 计算机科学 2026-03-24 Luca Cazzaniga

While there was great progress regarding the technology and its implementation for vehicles equipped with automated driving systems (ADS), the problem of how to proof their safety as a necessary precondition prior to market launch remains…

软件工程 · 计算机科学 2021-09-09 Nico Weber , Christoph Thiem , Ulrich Konigorski

In system development, epistemic uncertainty is an ever-present possibility when reasoning about the causal factors during hazard analysis. Such uncertainty is common when complicated systems interact with one another, and it is dangerous…

软件工程 · 计算机科学 2017-10-20 Chris Leong , Tim Kelly , Rob Alexander

As wearable health technologies have grown more sophisticated, the distinction between "wellness" and "medical" devices has become increasingly blurred. While some features undergo formal U.S. Food and Drug Administration (FDA) review, many…

In concurrent and distributed systems, software components are expected to communicate according to predetermined protocols and APIs - and if a component does not observe them, the system's reliability is compromised. Furthermore, isolating…

编程语言 · 计算机科学 2021-05-25 Christian Batrolo Burlò , Adrian Francalanza , Alceste Scalas

Selecting an automatic metric that best emulates human annotators is often non-trivial, because there is no clear definition of "best emulates." A meta-metric is required to compare the human judgments to the automatic metric scores, and…

计算与语言 · 计算机科学 2024-10-07 Brian Thompson , Nitika Mathur , Daniel Deutsch , Huda Khayrallah

Assistive machines endow people with limited mobility the opportunity to live more independently. However, operating these machines poses risks to the safety of the human operator as well as the surrounding environment. Thus, proper user…

人机交互 · 计算机科学 2022-05-19 Mahdieh Nejati Javaremi , Sisilia Sinaga , Yuming Jin , Matthew L. Elwin , Brenna Argall

The promise of Additive Manufacturing (AM) includes reduced transportation and warehousing costs, reduction of source material waste, and reduced environmental impact. AM is extremely useful for making prototypes and has demonstrated the…

计算机与社会 · 计算机科学 2017-06-05 Gregory Pope , Mark Yampolskiy

The Tokeneer project was an initiative set forth by the National Security Agency (NSA, USA) to be used as a demonstration that developing highly secure systems can be made by applying rigorous methods in a cost effective manner. Altran…

软件工程 · 计算机科学 2020-09-03 Maximiliano Cristiá , Gianfranco Rossi

Preclinical patient care is both mentally and physically challenging and exhausting for emergency teams. The teams intensively use medical technology to help the patient on site. However, they must carry and handle multiple heavy medical…

软件工程 · 计算机科学 2022-08-05 Christoph Stanik , Tim Puhlfürß , Anne Mahler , Phillip Brenya Sasu , Wikhart Reip , Walid Maalej

The complexity of digital embedded systems has been increasing in different safety-critical applications such as industrial automation, process control, transportation, and medical digital devices. The correct operation of these systems…

软件工程 · 计算机科学 2022-04-28 Fayhaa Hameedi Khlaif , Shawkat Sabah Khairullah

Industrial human-robot collaborative systems must be validated thoroughly with regard to safety. The sooner potential hazards for workers can be exposed, the less costly is the implementation of necessary changes. Due to the complexity of…

机器人学 · 计算机科学 2021-11-30 Tom P. Huck , Christoph Ledermann , Torsten Kröger

Autonomous driving systems (ADSs) promise improved transportation efficiency and safety, yet ensuring their reliability in complex real-world environments remains a critical challenge. Effective testing is essential to validate ADS…

计算机与社会 · 计算机科学 2025-12-16 Yihan Liao , Jingyu Zhang , Jacky Keung , Yan Xiao , Yurou Dai

Automated Decision-Making Systems (ADS) have become pervasive across various fields, activities, and occupations, to enhance performance. However, this widespread adoption introduces potential risks, including the misuse of ADS. Such misuse…

计算机与社会 · 计算机科学 2024-01-15 Marcelino Cabrera , Carlos Cruz , Pavel Novoa-Hernández , David A. Pelta , José Luis Verdegay

The increasing use of AI technologies has led to increasing AI incidents, posing risks and causing harm to individuals, organizations, and society. This study recognizes and addresses the lack of standardized protocols for reliably and…

计算机与社会 · 计算机科学 2025-01-28 Avinash Agarwal , Manisha J Nene

Healthcare is one of the largest business segments in the world and is a critical area for future growth. In order to ensure efficient access to medical and patient-related information, hospitals have invested heavily in improving clinical…

计算机与社会 · 计算机科学 2018-07-06 Andrea Marrella , Massimo Mecella , Mahmoud Sharf , Tiziana Catarci