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This study explores the production of radionuclides in a PMMA (Polymethylmethacrylate) phantom irradiated with Very High Energy Electrons (VHEE) beams as a novel method for dose verification. In this work, Monte Carlo simulation studies…

Radiotherapy using very high-energy electron (VHEE) beams generated by a laser-plasma accelerator has garnered significant interest due to its dose distribution capabilities and potential to address limitations of traditional photon-based…

Radiotherapy with Very High Energy Electron (VHEE) beams is being extensively investigated for the treatment of deep-seated tumours, even in view of novel protocols based on the so-called FLASH effect. Laser WakeField Acceleration (LWFA)…

A detection technique for ultra-high energy cosmic rays, complementary to the fluorescence technique, would be the use of the molecular Bremsstrahlung radiation emitted by low-energy ionization electrons left after the passage of the…

天体物理仪器与方法 · 物理学 2016-03-04 I. Al Samarai , C. Berat , O. Deligny , A. Letessier-Selvon , F. Montanet , M. Settimo , P. Stassi

FLASH Radiotherapy (RT) is a potentially new cancer radiotherapy technique where an entire therapeutic dose is delivered in about 0.1 s and at ~1000 times higher dose rate than in conventional RT. For clinical trials to be conducted safely,…

FLASH is a new treatment modality that requires optimization of dose, dose rate, and LET. Here we validate these three quantities under FLASH conditions, which includes the quantum uncertainty in the time-dependent instantaneous dose rate…

In fusion plasmas, where electron temperatures $T_e$ range from keV to hundreds of keV, Bremsstrahlung radiation constitutes a significant energy loss mechanism. While various thermal average fitting formulas exist in the literature, their…

等离子体物理 · 物理学 2024-10-28 Huasheng Xie

A detection technique of ultra-high energy cosmic rays, complementary to the fluorescence technique, would be the use of the molecular Bremsstrahlung radiation emitted by low-energy electrons left after the passage of the showers in the…

高能天体物理现象 · 物理学 2015-01-26 I. Al Samarai , O. Deligny , D. Lebrun , A. Letessier-Selvon , F. Salamida

The use of very high energy electron (VHEE) beams for radiotherapy has been actively studied for over two decades due to their advantageous dose distribution, deep penetration depth and great potential of ultra-high dose-rate irradiation.…

医学物理 · 物理学 2026-04-30 Bing Zhou , Zhiyuan Guo , Yang Wan , Shuang Liu , Jianfei Hua , Wei Lu

Heavy-ion therapy, particularly using scanned (active) beam delivery, provides a precise and highly conformal dose distribution, with maximum dose deposition for each pencil beam at its endpoint (Bragg peak), and low entrance and exit dose.…

Bremsstrahlung photon beams produced by medical linear accelerators are currently the most commonly used method of radiation therapy for cancerous tumors. Photons with energies greater than 8-10 MeV potentially generate neutrons through…

加速器物理 · 物理学 2013-07-11 Danial Salehi , M. Salehi Jozani , Dariush Sardari

PET imaging is a non-invasive technique for particle range verification in proton therapy. It is based on measuring the beta+ annihilations caused by nuclear interactions of the protons in the patient. In this work we present measurements…

The FLASH effect holds significant potential in improving radiotherapy treatment outcomes. Very high energy electrons (VHEEs) can effectively target tumors deep in the body and can be accelerated to achieve ultra-high dose rates (UHDR),…

We calculate the emission of bremsstrahlung from lead and argon ions in A Fixed Target ExpeRiment (AFTER) that uses the LHC beams. With nuclear charges of $Ze$ equal $208$ and $18$ respectively, these ions are accelerated to energies of $7$…

核实验 · 物理学 2015-03-27 Rune E. Mikkelsen , Allan H. Sørensen , Ulrik I. Uggerhøj

While spatial dose conformity delivered to a target volume has been pushed to its practical limits with advanced treatment planning and delivery, investigations in novel temporal dose delivery are unfolding new mechanisms. Recent advances…

Ultra high dose rate electron beams also known as FLASH radiotherapy is becoming of importance in several preclinial cancer treatment studies. However, due to the dose rate used during the irradiation sessions, no real time dose monitoring…

医学物理 · 物理学 2022-08-19 Chloe Lahaye , Jean-Marc Fontbonne , Samuel Salvador

A new method of experimental verification of radial dose distribution models using solid state thermoluminescent (TL) detectors LiF:Mg,Cu,P has been recently proposed. In this work the method was applied to verify the spatial distribution…

仪器与探测器 · 物理学 2014-01-28 W. Gieszczyk , P. Bilski , P. Olko , B. Obryk

Purpose: To verify dose delivery and quality assurance of volumetric modulated arc therapy (VMAT) for head and neck cancer. Method: The Imaging and Radiation Oncology Core Houston (IROC-H) head and neck phantom with thermo- luminescent…

Purpose: Various dose calculation algorithms are available for radiation therapy for cancer patients. However, these algorithms are faced with the tradeoff between efficiency and accuracy. The fast algorithms are generally less accurate,…

医学物理 · 物理学 2020-07-01 Yixun Xing , Dan Nguyen , Weiguo Lu , Ming Yang , Steve Jiang

We propose to develop deep learning models that can predict Pareto optimal dose distributions by using any given set of beam angles, along with patient anatomy, as input to train the deep neural networks. We implement and compare two deep…

医学物理 · 物理学 2021-01-27 Gyanendra Bohara , Azar Sadeghnejad Barkousaraie , Steve Jiang , Dan Nguyen
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