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Charged Particle Therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbons. A critical issue is the monitoring of the dose released by the beam to the tumor and to the surrounding tissues. We present…

Radiotherapy using very-high-energy electron (VHEE) beams (50-300 MeV) has attracted considerable attention due to its advantageous dose deposition characteristics, enabling deep penetration and the potential for ultra-high dose rate…

The paper reports the results of measuring the total dose of X-ray bremsstrahlung from a powerful X-ray source based on the high-current pulsed direct-action electron accelerator Temp-B. The parameters of the high-current, tubular…

The bremsstrahlung spectra produced by electrons impinging on thick targets are simulated using the Geant4 Monte Carlo toolkit. Simulations are validated against experimental data available in literature for a range of energy between 0.5…

医学物理 · 物理学 2015-04-10 Luciano Pandola , Claudio Andenna , Barbara Caccia

Due to the increasing complexity of radiotherapy delivery, accurate dose verification has become an essential part of the clinical treatment process. The purpose of this work was to develop an electronic portal image (EPI) based…

医学物理 · 物理学 2015-06-17 Reid W Townson , Sergei Zavgorodni

In this paper, we provide a procedure to calculate the bremsstrahlung spectrum for virtually any relativistic bare ion with charge 6$e$ or beyond, $Z\ge 6$, in ultraperipheral collisions with target nuclei. We apply the…

核理论 · 物理学 2016-03-23 R. E. Mikkelsen , A. H. Sørensen , U. I. Uggerhøj

Relativistic electrons generated by the interaction of petawatt-class short laser pulses with solid targets can be used to generate bright X-rays via bremsstrahlung. The efficiency of laser energy transfer into these electrons depends on…

The next great leap toward improving treatment of cancer with radiation will require the combined use of online adaptive and magnetic resonance guided radiation therapy techniques with automatic X-ray beam orientation selection.…

医学物理 · 物理学 2019-08-14 Ryan Neph , Yangsibo Huang , Youming Yang , Ke Sheng

Conventional radiotherapy dose calculation algorithms are often computationally slow and non-differentiable, creating bottlenecks for online adaptive radiotherapy (ART) and limiting end-to-end automatic planning. Deep learning provides…

Proton FLASH therapy leverages ultra-high dose-rate radiation to enhance the sparing of organs at risk without compromising tumor control probability. To prepare for the delivery of high doses to targets, we aim to develop a deep…

We have demonstrated the use of the bremsstrahlung radiation in energy dispersive x-ray fluorescence technique as a tool to perform non-destructive elemental analysis of solid samples employed in inter-disciplinary science research. The…

仪器与探测器 · 物理学 2023-03-06 Soumya Chatterjee , Sumana Ghosh , D. Mitra

FLASH-RT has proven beneficial in preclinical studies. However, the lack of accurate real time 2D dosimetry is a limiting factor. In this work, an innovative solution for 2D real time dosimetry in UHDR electron beams is presented. The…

An intense, short laser pulse incident on a transparent dielectric can excite electrons from valence to the conduction band. As these electrons undergo scattering, both from phonons and ions, they emit bremsstrahlung radiation. Here we…

等离子体物理 · 物理学 2017-05-31 G. M. Petrov , J. P. Palastro , J. Peñano

Dose verification based on proton-induced positron emitters is a promising quality assurance tool and may leverage the strength of artificial intelligence. To move a step closer towards practical application, the sensitivity analysis of two…

医学物理 · 物理学 2022-12-23 Shixiong Yu , Yuxiang Liu , Zongsheng Hu , Haozhao Zhang , Pengyu Qi , Hao Peng

The recent interest in beta- radionuclides for radio-guided surgery derives from the feature of the beta radiation to release energy in few millimeters of tissue. Such feature can be used to locate residual tumors with a probe located in…

Longitudinal phase space (LPS) provides a critical information about electron beam dynamics for various scientific applications. For example, it can give insight into the high-brightness X-ray radiation from a free electron laser. Existing…

加速器物理 · 物理学 2021-02-09 A. Hanuka , C. Emma , T. Maxwell , A. Fisher , B. Jacobson , M. J. Hogan , Z. Huang

Purpose: This is a theoretical simulation study for proof of concept of radiochromic film dosimetry to measure physical and biological doses without plan-based quenching correction for patient-specific quality assurance of carbon-ion…

医学物理 · 物理学 2019-03-25 Nobuyuki Kanematsu , Taku Inaniwa , Shunsuke Yonai , Hideyuki Mizuno

The analysis of beamstrahlung radiation, emitted from a beam of charged particles due to the electromagnetic interaction with a second beam of charged particles, provides a diagnostic tool that can be used to monitor beam-beam collisions in…

仪器与探测器 · 物理学 2017-03-28 Salvatore Di Carlo , Fabrizio Messina

As computational complexity in electromagnetics increases with frequency, full-wave solvers become computationally infeasible for electrically large problems. To address this limitation, we present a shooting and bouncing rays (SBR) method…

计算工程、金融与科学 · 计算机科学 2026-04-13 Marco Pasquale , Andong Hu , Luca Pennati , Ivy Peng , Stefano Markidis

The photon flux resulting from high-energy electron beam interactions with high field systems, such as in the upcoming FACET-II experiments at SLAC National Accelerator Laboratory, may give deep insight into the electron beam's underlying…

加速器物理 · 物理学 2023-09-26 M. Yadav , M. Oruganti , S. Zhang , B. Naranjo , G. Andonian , Y. Zhuang , Ö. Apsimon , C. P. Welsch , J. B. Rosenzweig