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To date, very few biomedical signals have transitioned from research applications to clinical applications. This is largely due to the lack of trust in the diagnostic ability of non-stationary signals. To reach the level of clinical…

机器学习 · 计算机科学 2023-09-26 Rui Gong , Kazunori Hase

Parkinsons Disease is a neurological disorder and prevalent in elderly people. Traditional ways to diagnose the disease rely on in-person subjective clinical evaluations on the quality of a set of activity tests. The high-resolution…

机器学习 · 计算机科学 2020-10-16 Weijian Li , Wei Zhu , E. Ray Dorsey , Jiebo Luo

In this work, we use a deep learning framework for simultaneous classification and regression of Parkinson disease diagnosis based on MR-Images and personal information (i.e. age, gender). We intend to facilitate and increase the confidence…

计算机视觉与模式识别 · 计算机科学 2018-06-15 Soheil Esmaeilzadeh , Yao Yang , Ehsan Adeli

Several diseases of parkinsonian syndromes present similar symptoms at early stage and no objective widely used diagnostic methods have been approved until now. Positron emission tomography (PET) with $^{18}$F-FDG was shown to be able to…

In recent years, single modality based gait recognition has been extensively explored in the analysis of medical images or other sensory data, and it is recognised that each of the established approaches has different strengths and…

计算机视觉与模式识别 · 计算机科学 2021-01-08 Aite Zhao , Jianbo Li , Junyu Dong , Lin Qi , Qianni Zhang , Ning Li , Xin Wang , Huiyu Zhou

Microbiota profiles measure the structure of microbial communities in a defined environment (known as microbiomes). In the past decade, microbiome research has focused on health applications as a result of which the gut microbiome has been…

定量方法 · 定量生物学 2021-05-11 Benjamin Wingfield , Sonya Coleman , T. M. McGinnity , Anthony J. Bjourson

Background and objectives: Parkinson's disease is a neurological disorder that affects the motor system producing lack of coordination, resting tremor, and rigidity. Impairments in handwriting are among the main symptoms of the disease.…

Due to the aging of the world population and westernization of lifestyles, the prevalence of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is rapidly rising and is expected to put a strong…

Since no effective therapies exist for Alzheimer's disease (AD), prevention has become more critical through lifestyle factor changes and interventions. Analyzing electronic health records (EHR) of patients with AD can help us better…

计算与语言 · 计算机科学 2021-01-26 Zitao Shen , Yoonkwon Yi , Anusha Bompelli , Fang Yu , Yanshan Wang , Rui Zhang

The so-called gut-brain axis has stimulated extensive research on microbiomes. One focus is to assess the association between certain clinical outcomes and the relative abundances of gut microbes, which can be presented as sub-compositional…

统计方法学 · 统计学 2020-06-02 Xiaokang Liu , Xiaomei Cong , Gen Li , Kendra Maas , Kun Chen

Identification of features is a critical task in microbiome studies that is complicated by the fact that microbial data are high dimensional and heterogeneous. Masked by the complexity of the data, the problem of separating signals from…

统计方法学 · 统计学 2020-09-18 Liangliang Zhang , Yushu Shi , Kim-Anh Do , Christine B. Peterson , Robert R. Jenq

There is great interest in developing radiological classifiers for diagnosis, staging, and predictive modeling in progressive diseases such as Parkinson's disease (PD), a neurodegenerative disease that is difficult to detect in its early…

We seek to identify genes involved in Parkinson's Disease (PD) by combining information across different experiment types. Each experiment, taken individually, may contain too little information to distinguish some important genes from…

Biologically inspired model (BIM) for image recognition is a robust computational architecture, which has attracted widespread attention. BIM can be described as a four-layer structure based on the mechanisms of the visual cortex. Although…

计算机视觉与模式识别 · 计算机科学 2017-10-30 Yan-Feng Lu , Li-Hao Jia , Hong Qaio , Yi Li

This paper reviews related work and state-of-the-art publications for recognizing motor symptoms of Parkinson's Disease (PD). It presents research efforts that were undertaken to inform on how well traditional machine learning algorithms…

人工智能 · 计算机科学 2013-12-16 Claas Ahlrichs , Michael Lawo

Polymicrogyria (PMG) is a disorder of cortical organization mainly seen in children, which can be associated with seizures, developmental delay and motor weakness. PMG is typically diagnosed on magnetic resonance imaging (MRI) but some…

计算机视觉与模式识别 · 计算机科学 2022-11-24 Lingfeng Zhang , Nishard Abdeen , Jochen Lang

Eye-tracking is an accessible and non-invasive technology that provides information about a subject's motor and cognitive abilities. As such, it has proven to be a valuable resource in the study of neurodegenerative diseases such as…

机器学习 · 计算机科学 2023-11-29 Gonzalo Uribarri , Simon Ekman von Huth , Josefine Waldthaler , Per Svenningsson , Erik Fransén

Characterising the heterogeneous presentation of Parkinson's disease (PD) requires integrating biological and clinical markers within a unified predictive framework. While multimodal data provide complementary information, many existing…

机器学习 · 计算机科学 2026-01-05 Dristi Datta , Tanmoy Debnath , Minh Chau , Manoranjan Paul , Gourab Adhikary , Md Geaur Rahman

In this paper, an explainable deep learning-based classifier based on adaptive sinc filters for Parkinson's Disease diagnosis (PD) along with determining its severity, based on analyzing the gait cycle (SincPD) is presented. Considering the…

信号处理 · 电气工程与系统科学 2025-02-26 Armin Salimi-Badr , Mahan Veisi , Sadra Berangi

Numerous studies have shown that microbial metabolites, which represent the products of bacteria in the human gut, play a key role in shaping cancer risk and response to treatment. However, metabolite data typically contain a large…

应用统计 · 统计学 2026-05-19 Kai Jiang , Satabdi Saha , Christine B. Peterson